Download PDF
Arthritis und Rheuma 2014; 34(06): 335-342
DOI: 10.1055/s-0037-1619119
Interdisziplinäre Kinderrheumatologie
Schattauer GmbH

Augenbeteiligung bei rheumatischen Erkrankungen

Ein ÜberblickOcular involvement in rheumatic diseasesAn overview
C. Sengler
1   Deutsches Rheuma-Forschungszentrum Berlin, Programmbereich Epidemiologie, Berlin
,
J. Schroeter
2   Universitätsgewebebank, Centrum für Transfusionsmedizin, Charité – Universitätsmedizin Berlin
,
C. Meltendorf
3   Universitätsaugenklinik, Universitätsklinikum Magdeburg A. ö. R., Magdeburg
› Author Affiliations
Further Information

Publication History

Publication Date:
27 December 2017 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Bei chronisch entzündlichen Systemerkrankungen wie der rheumatoiden Arthritis, aber insbesondere auch bei Vaskulitiden, können die Augen mit all ihren Strukturen (Konjunktiva, Sklera, Kornea, Uvea, Retina, Sehnerv) mitbetroffen sein und zum Teil sogar die Aktivität der Grunderkrankung widerspiegeln. Die Kenntnis von okulären Beteiligungen bei Erkrankungen aus dem rheumatischen Formenkreis ist wichtig, um gegebenenfalls im Verlauf rechtzeitig entzündlich bedingte Veränderungen am Auge therapieren und damit das Sehvermögen erhalten zu können. Im Folgenden werden die häufigsten okulären Manifestationen spezifischer chronisch entzündlicher Erkrankungen mit ihren wichtigsten Charakteristika dargestellt.

Summary

In chronic inflammatory diseases like rheumatoid arthritis as well as different vasculitic syndromes, the eyes can be involved with all their structures (conjunctiva, sclera, cornea, uvea, retina, optic nerve) and may partially even reflect the activity of the underlying disease. So knowledge about ocular involvement of these chronic inflammatory conditions is important to be able to timely treat ocular manifestations and to possibly prevent visual loss. In the following, the most common ocular manifestations of several chronic inflammatory conditions will be described with their main characteristics.

Schlüsselwörter

Entzündliche Systemerkrankung - rheumatische Erkrankung - Augenbeteiligung

Keywords

Chronic inflammatory disease - rheumatic disease - ocular involvement
 

  • Literatur

  • 1 McDermot EM, McDevitt H. The immunogenetics of rheumatic diseases. Bulletin on the Rheumatic Diseases 1988; 38 (01) 1-10.
    PubMedSearch in Google Scholar
  • 2 Choudhary MM, Hajj-Ali RA, Lowder CY. Gender and ocular manifestations of connective tissue diseases and systemic vasculitides. J Ophthalmol 2014; Article ID 403042
    PubMedSearch in Google Scholar
  • 3 Akpek EK, Thorne JE, Qazi FA. et al. Evaluation of patients with scleritis for systemic disease. Ophthalmology 2004; 111: 501-506.
    CrossrefPubMedSearch in Google Scholar
  • 4 Foster CS, Forstot SL, Wilson LA. Mortality rate in rheumatoid arthritis patients developing necrotizing scleritis or peripheral ulcerative keratitis. Effects of systemic immunosuppression. Ophthalmology 1984; 91: 1253-1263.
    CrossrefPubMedSearch in Google Scholar
  • 5 Tincani A, Andreoli L, Cavazzana I. et al. Novel aspects of Sjögren’s syndrome in 2012. BMC Med 2013; 11 (93) 1741.
    Search in Google Scholar
  • 6 Hu Q, Wang D, Chen W. The accuracy of the anti-α-fodrin antibody test for diagnosis of Sjögren’s syndrome: a meta-analysis. Clin Biochem 2013; 46: 1372-1376.
    CrossrefPubMedSearch in Google Scholar
  • 7 Davies JB, Rao PK. Ocular manifestations of systemic lupus erythematosus. Curr Opin Ophthalmol 2008; 19: 512-518.
    CrossrefPubMedSearch in Google Scholar
  • 8 Ushiyama O, Ushiyama K, Koarada S. et al. Retinal disease in patients with systemic lupus erythematosus. Ann Rheum Dis 2000; 59: 705-708.
    CrossrefPubMedSearch in Google Scholar
  • 9 Stafford-Brady FJ, Urowitz MB, Gladman DD, Easterbrook M. Lupus retinopathy. Patterns, associations, and prognosis. Arthritis Rheum 1988; 31: 1105-1110.
    CrossrefPubMedSearch in Google Scholar
  • 10 Montehermoso A, Cervera R, Font J. et al. Association of antiphospholipid antibodies with retinal vascular disease in systemic lupus erythematosus. Semin Arthritis Rheum 1999; 28: 326-332.
    CrossrefPubMedSearch in Google Scholar
  • 11 Sivaraj RR, Durrani OM, Denniston AK. et al. Ocular manifestations of systemic lupus erythematosus. Rheumatology 2007; 46: 1757-1762.
    CrossrefPubMedSearch in Google Scholar
  • 12 Tansley SL, Betteridge ZE, McHugh NJ. The diagnostic utility of autoantibodies in adult and juvenile myositis. Curr Opin Rheumatol 2013; 25: 772-777.
    CrossrefPubMedSearch in Google Scholar
  • 13 Jennette JC, Falk RJ, Bacon PA. et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum 2013; 65: 1-11.
    CrossrefPubMedSearch in Google Scholar
  • 14 Pakrou N, Selva D, Leibovitch I. Wegener’s granulomatosis: ophthalmic manifestations and management. Semin Arthritis Rheum 2006; 35: 284-292.
    CrossrefPubMedSearch in Google Scholar
  • 15 Ladas JG, Mondino BJ. Systemic disorders associated with peripheral corneal ulceration. Curr Opin Ophthalmol 2000; 11: 468-471.
    CrossrefPubMedSearch in Google Scholar
  • 16 Garrity JA. Ocular manifestations of small-vessel vasculitis. Cleve Clin J Med 2012; 79 (Suppl. 03) S31-S33.
    CrossrefPubMedSearch in Google Scholar
  • 17 International Study Group for Behçet’s Disease. Criteria for diagnosis of Behçet’s disease. Lancet 1990; 335: 1078-1080.
    PubMedSearch in Google Scholar
  • 18 International Team for the Revision of the International Criteria for Behçet’s Disease. Revision of the International Criteria for Behçet’s disease (ICBD). Clin Exp Rheumatol 2006; 24 (Suppl. 42) S14-S15.
    PubMedSearch in Google Scholar
  • 19 Mahr A, Belarbi L, Wechsler B. et al. Population-based prevalence study of Behçet’s disease: differences by ethnic origin and low variation by age at immigration. Arthritis Rheum 2008; 58: 3951-3959.
    CrossrefPubMedSearch in Google Scholar
  • 20 Kitaichi N, Miyazaki A, Iwata D. et al. Ocular features of Behçet’s disease: an international collaborative study. Br J Ophthalmol 2007; 91: 1579-1582.
    CrossrefPubMedSearch in Google Scholar
  • 21 Peter J, David S, Danda D. et al. Ocular manifestations of Takayasu arteritis: a cross-sectional study. Retina 2011; 31 (06) 1170-1178.
    CrossrefPubMedSearch in Google Scholar
  • 22 Ness T, Bley TA, Schmidt WA, Lamprecht P. The diagnosis and treatment of giant cell arteritis. Dtsch Arztebl Int 2013; 110 (21) 376-385.
    CrossrefPubMedSearch in Google Scholar
  • 23 Rothova A. Ocular involvement in sarcoidosis. Br J Ophthalmol 2000; 84: 110-116.
    CrossrefPubMedSearch in Google Scholar
  • 24 Zeboulon N, Dougados M, Gossec L. Prevalence and characteristics of uveitis in the spondyloarthropathies: a systematic literature review. Ann Rheum Dis 2008; 67: 955-959.
    CrossrefPubMedSearch in Google Scholar
  • 25 Lyons JL, Rosenbaum JT. Uveitis associated with inflammatory bowel disease compared with uveitis associated with spondyloarthropathy. Arch Ophthalmol 1997; 115: 61-64.
    CrossrefPubMedSearch in Google Scholar
  • 26 Paiva ES, Macaluso DC, Edwards A, Rosenbaum JT. Characterisation of uveitis in patients with psoriatic arthritis. Ann Rheum Dis 2000; 59: 67-70.
    CrossrefPubMedSearch in Google Scholar
  • 27 Monnet D, Breban M, Hudry C. et al. Ophthalmic findings and frequency of extraocular manifestations in patients with HLA-B27 uveitis: a study of 175 cases. Ophthalmology 2004; 111: 802-809.
    CrossrefPubMedSearch in Google Scholar
  • 28 Petty RE, Southwood TR, Manners P. International League of Associations for Rheumatology. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 2004; 31: 390-392.
    Search in Google Scholar
  • 29 Heiligenhaus A, Niewerth M, Ganser G. et al. German Uveitis in Childhood Study Group. Prevalence and complications of uveitis in juvenile idiopathic arthritis in a population-based nation-wide study in Germany: suggested modification of the current screening guidelines. Rheumatology 2007; 46: 1015-1019
    CrossrefPubMedSearch in Google Scholar