Pneumologie 2018; 72(S 01): S92
DOI: 10.1055/s-0037-1619362
Sektion 7 – Klinische Pneumologie
Posterbegehung – Titel: COPD II
Georg Thieme Verlag KG Stuttgart · New York

Influecence of cardiovascular risk factors on health related quality of life in patients with chronic obstructive pulmonary disease. Differences between frequent and infrequent exacerbator phenotype

EJ Soto Hurtado
1   Unidad de Gestión Clínica de Enfermedades Respiratorias. Hospital Regional Universitario. Málaga
,
P Gutiérrez Castaño
1   Unidad de Gestión Clínica de Enfermedades Respiratorias. Hospital Regional Universitario. Málaga
,
A Doménech del Rio
2   Neumology Service. Hospital Regional Universitario de Málaga
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Publikationsdatum:
21. Februar 2018 (online)

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Introductions:

Chronic obstructive pulmonary disease (COPD) has a high impact on health related quality of life (HRQoL). Our understanding of how cardiovascular risk factors (CVRF) influence health-related quality of life (HRQL) in patients with COPD is limited and in need of improvement. The aim our study is to examine the associations between CVRF and HRQL according to frequent and non frequent exacerbator phenotype in patients with severe COPD.

Material and methods:

This cross-sectional study recruited 101 patients with COPD leaded to a monografic outpatient consult. Anamnesis and physical exploration was collected, including number of exacerbations. A fasting blood sample was drawn, measuring lipids and inflammatory parameters. Patients completed the St George's Respiratory Questionnaire (SGRQ) and the COPD Assessment Test (CAT). Cardiovascular risk was estimated following Framingham and SCORE equations.

Results:

Patients showed severe obstruction (FEV1 43.9%) and high prevalence of CVRF as assesed by Framingham (26 ± 16,8) and SCORE (7,9 ± 10,5). In a global analysis, frequent exacerbator phenotype was significantly associated with a worse HRQL as assessed by CAT (p < 0,001) and the three domains of SGRQ (activity [p < 0,001],impact [p < 0,003] and symptoms [p < 0,001]). Having high prevalence of CVRF was associated with a tendence to worse HRQoL as assessed by all instruments in infrequent exacerbators. It was statistically significant in impact domain of SGRQ and CAT. This difference was not found in frequent exacerbators.

Conclusions:

The reduction of exacerbation frequency is a main point in the management of COPD patients, because frequent exacerbators have a worse HRQoL compared with infrequent exacerbators. The infrequent exacerbator phenotype with high CVR has a worse HRQoL; in consequence, additional attention should be given to identify this group and optimize their care.