Kandidatengene und neue therapeutische Möglichkeiten für Osteoporose

B. Obermayer-Pietsch

doi:10.1055/s-0037-1619998

Osteologie, Table of Contents

Osteologie 2011; 20(03): 227-232
DOI: 10.1055/s-0037-1619998

Knochenzellbiologie und Osteoporosetherapie

Schattauer GmbH

Kandidatengene und neue therapeutische Möglichkeiten für Osteoporose

Candidate genes and new therapeutic options for osteoporosis

B. Obermayer-Pietsch

¹Klinische Abteilung und Labor für Endokrinologie und Stoffwechsel, §68-Einrichtung für Genanalysen, Universitäts- klinik für Innere Medizin, Medizinische Universität Graz, Österreich

› Author Affiliations

Abstract

Zusammenfassung

Die genetischen Grundlagen der Osteoporose werden seit Langem intensiv beforscht. Bisher wurden bereits zahlreiche wichtige Kandidatengene für Knochendichte identifiziert – genetische Varianten in diesen Genen sind für einen Teil der individuellen Knochenmasse verantwortlich. Relevante Stoffwechselwege werden bereits für therapeutische Anwendungen genutzt. Aufgrund von neuen großangelegten genomweiten Assoziationsanalysen sind nun teils völlig neue Kandidatengene vorgestellt worden, die in Zukunft nicht nur Licht auf die komplexen pathophysiologischen Grundlagen der Osteoporose werfen werden, sondern auch für die Entwicklung neuer Therapeutika wichtig sein könnten.

Summary

The genetic background of osteoporosis has long been investigated. Several genetic loci have been identified, which have already been shown to be associated with an increased risk for low bone mineral density. Critical bone pathways out of these genes have been used to develop therapeutic applications. Based on huge genome-wide association studies, new candidate genes for bone mineral density and osteoporotic fractures have now been reported. They will not only shed light on the complex pathophysiological pathways of osteoporosis, but might also be the basis for the development of new therapeutic drugs for osteoporosis.

Schlüsselwörter

Kandidatengene - Polymorphismen - Osteoporose - GWAS

Keywords

Candidate gene - polymorphism - osteoporosis - GWAS

Full Text

References

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