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Arthritis und Rheuma 2009; 29(03): 179-185
DOI: 10.1055/s-0037-1620163
Bildgebung in der Rheumatologie
Schattauer GmbH

Kapillarmikroskopie

Capillary microscopy
C. Dechant
1   Rheuma-Einheit, Medizinische Poliklinik, Klinikum der Universität München – Campus Innenstadt
,
O. Sander
2   Rheumatologie, Heinrich Heine-Universität Düsseldorf
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
24. Dezember 2017 (online)

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Zusammenfassung

Die Kapillarmikroskopie ist ein einfaches Verfahren, das eine den Patienten nicht belastende Beurteilung der Mikrozirkulation zulässt. Obwohl es sich um eine sehr alte Methode handelt, findet sie erst in den letzten Jahren wieder eine zunehmende Verbreitung in der klinischen Anwendung. Die Methode besitzt einen großen Stellenwert bei der differenzialdiagnostischen Einordnung des Raynaud-Phänomens.

Summary

Nailfold capillary microscopy is a simple procedure for evaluating the microcirculation with high patient tolerability. Despite being a very old method its clinical use has expanded within the last years. This method is particularly useful for the differential diagnosis of Raynaud’s phenomenon.

Schlüsselwörter

Kapillarmikroskopie - Mikrozirkulation - Raynaud-Syndrom - Sklerodermie

Keywords

Capillary microscopy - micro circulation - Raynaud’s phenomenon - scleroderma
 

  • Literatur

  • 1 Anders HJ, Sigl T, Schattenkirchner M. Differentiation between primary and secondary Raynaud's phenomenon: a prospective study comparing nail-fold capillaroscopy using an ophthalmoscope or stereomicroscope. Ann Rheum Dis 2001; 60: 407-409.
    CrossrefPubMedGoogle Scholar
  • 2 Anderson ME, Allen PD, Moore T. et al. Computer-ized nailfold video capillaroscopy – a new tool for assessment of Raynaud's phenomenon. J Rheumatology 2005; 32: 841-848.
    Google Scholar
  • 3 Bierbrauer von A, Barth P, Willert J. et al. Electron microscopy and capillaroscopically guided nailfold biopsy in connective tissue diseases: detection of ultrastructural changes of the microcirculatory vessels. Br J Rheumatol 1998; 37: 1272-1278.
    CrossrefPubMedGoogle Scholar
  • 4 Binaghi F, Cannas F, Mathieu A, Pitzus F. Correlations among capillaroscopic abnormalities, digital flow and immunologic findings in patients with isolated Raynaud's phenomenon. Can laser Doppler flowmetry help identify a secondary Raynaud phenomenon?. Int Angiol 1992; 11: 186-194.
    Google Scholar
  • 5 Bukhari M, Hollis S, Moore T. et al. Quantification of microcirculatory abnormalities in patients with primary Raynaud's phenomenon and systemic sclerosis by video capillaroscopy. Rheumatology (Oxford) 2000; 39: 506-512.
    CrossrefPubMedGoogle Scholar
  • 6 Carpentier P, Franco A. Atlas der Kapillaroskopie. Wiesbaden: Abbott GmbH. 1983
    Google Scholar
  • 7 Cutolo M, Grassi W, Matucci Cerinic M. Raynaud's phenomenon and the role of capillaroscopy. Arthritis Rheum 2003; 48: 3023-3030.
    CrossrefPubMedGoogle Scholar
  • 8 Cutolo M, Pizzorni C, Sulli A. Nailfold video-cap-illaroscopy in systemic sclerosis. Z Rheumatol 2004; 63: 457-462.
    CrossrefPubMedGoogle Scholar
  • 9 Czirják L, Kiss CG, Lövei C. et al. Survey of Raynaud's phenomenon and systemic sclerosis based on a representative study of 10,000 south-Trans-danubian Hungarian inhabitants. Clin Exp Rheumatol 2005; 23: 801-808.
    PubMedGoogle Scholar
  • 10 DeBure C, Fiessinger JN, Priollet P. et al. Relationship between nailfold capillary microscopy and salivary capillary basement membrane width in Raynaud's disease and progressive systemic sclerosis. J Rheumatol 1985; 12: 279-282.
    Google Scholar
  • 11 Fahrig C, Heidrich H, Voigt B, Wnuk G. Capillary microscopy of the nailfold in healthy subjects. Int J Microcirc Clin Exp 1995; 15: 287-292.
    CrossrefPubMedGoogle Scholar
  • 12 Fahrig C, Breitinger L, Heidrich H. Vital capillary microscopic findings in the nailfold of patients with diabetes mellitus. Vasa 2000; 29: 258-263.
    CrossrefPubMedGoogle Scholar
  • 13 Ingegnoli F, Zeni S, Meani L. et al. Evaluation of nail-fold videocapillaroscopic abnormalities in patients with systemic lupus erythematosus. J Clin Rheumatol 2005; 11: 295-298.
    CrossrefPubMedGoogle Scholar
  • 14 Kabasakal Y, Elvins DM, Ring EF, McHugh NJ. Quantitative nailfold capillaroscopy findings in a population with connective tissue disease and in normal healthy controls. Ann Rheum Dis 1996; 55: 507-512.
    CrossrefPubMedGoogle Scholar
  • 15 Kröger K, Billen T, Neuhaus G. et al. Relevance of low titers of cryoglobulins and cold-agglutinins in patients with isolated Raynaud phenomenon. Clin Hemorheol Microcirc 2002; 24: 167-174.
    Google Scholar
  • 16 Lonzetti LS, Joyal F. Raynauld JP. et al. Updating the American College of Rheumatology preliminary classification criteria for systemic sclerosis: addition of severe nailfold capillaroscopy abnormalities markedly increases the sensitivity for limited scleroderma. Arthritis Rheum 2001; 44: 735-736.
    CrossrefPubMedGoogle Scholar
  • 17 Mannarino E, Pasqualini L, Fedeli F. et al. Nailfold capillaroscopy in the screening and diagnosis of Raynaud's phenomenon. Angiology 1994; 45: 37-42.
    CrossrefPubMedGoogle Scholar
  • 18 Maricq HR, LeRoy EC, D'Angelo WA. et al. Diagnostic potential of in vivo capillary microscopy in scleroderma and related disorders. Arthritis Rheum 1980; 23: 183-189.
    CrossrefPubMedGoogle Scholar
  • 19 Maricq HR, Weinberger AB, LeRoy EC. Early detection of scleroderma-spectrum disorders by in vivo capillary microscopy: a prospective study of patients with Raynaud's phenomenon. J Rheumatol 1982; 9: 289-291.
    Google Scholar
  • 20 Meli M, Gitzelmann G, Koppensteiner R, Amann-Vesti BR. Predictive value of nailfold capillaroscopy in patients with Raynaud’s phenomenon. Clin Rheumatol 2006; 25: 153-158.
    CrossrefPubMedGoogle Scholar
  • 21 Merlen JF. Phénomène de Raynaud et sclérodermie. Ann Cardiol Angéiol 1980; 29: 333-337.
    Google Scholar
  • 22 Müller O. Die Kapillaren der menschlichen Körperoberfläche in gesunden und kranken Tagen. Stuttgart: Ferdinand Enke; 1922
    Google Scholar
  • 23 Pavlov-Dolijanovic S, Damjanov N, Ostojic N. et al. The prognostic value of nailfold capillary changes for the development of connective tissue disease in children and adolescents with primary Raynaud phenomenon: A follow-up study of 250 patients. Pediatric Dermatology 2006; 23: 437-444.
    CrossrefPubMedGoogle Scholar
  • 24 Riccieri V, Spadaro A, Ceccarelli F. et al. Nailfold capillaroscopy changes in systemic lupus erythematosus: correlations with disease activity and auto-antibody profile. Lupus 2005; 14: 521-525.
    CrossrefPubMedGoogle Scholar
  • 25 Ross JB. Nail fold capillaroscopy – a useful aid in the diagnosis of collagen vascular diseases. J Invest Dermatol 1996; 282-285.
    Google Scholar
  • 26 Sander O, Sunderkötter C, Kötter I. et al Kapillarmikroskopie: Durchführung und Nomenklatur. Z Rheumatol (submitted for publication).
  • 27 Sander O, Iking-Konert C, Ostendorf B. Taschenat-las Kapillarmikroskopie. Rheumazentrum Rhein-Ruhr, Düsseldorf 2007
  • 28 Wollheim FA. Classification of systemic sclerosis. Visions and reality. Rheumatology (Oxford) 2005; 44: 1212-1216.
    CrossrefPubMedGoogle Scholar
  • 29 Zaric D, Worm AM, Stahl D, Clemmensen OJ. Capillary microscopy of the nailfold in psoriatic and rheumatoid arthritis. Scand J Rheumatol 1981; 10: 249-252.
    CrossrefPubMedGoogle Scholar
  • 30 Zufferey P, Depairon M, Chamot AM, Monti M. Prognostic significance of nailfold capillary microscopy in patients with Raynaud's phenomenon and scleroderma-pattern abnormalities. A six-year follow-up study. Clin Rheumatol 1992; 11: 536-541.
    CrossrefPubMedGoogle Scholar