Abstract
Bacillus Calmette–Guérin (BCG) vaccine is administered to infants in countries with
a high prevalence of tuberculosis. Severe combined immunodeficiency (SCID) is one
of the most severe forms of primary immunodeficiency disease, rendering patients prone
to disseminated BCG infection. Early intensive antimycobacterial treatment and bone
marrow transplantation may be lifesaving in patients with BCG infection and SCID.
The central nervous system is rarely involved in BCG infection. We report a case of
disseminated BCG infection with diffuse intracranial calcification, including periventricular
white matter, subcortical area, pons and cerebellar white matter after bone marrow
transplantation.
Keywords
severe combined immunodeficiency - disseminated BCG infection - intracranial calcification
- central nervous system
