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Nuklearmedizin 1982; 21(04): 150-156
DOI: 10.1055/s-0037-1620570
Originalarbeiten – Original Articles
Schattauer GmbH

Studies of the Chemical and Biological Properties of the Skeletal Imaging Agent 99mTc-Methylene Diphosphonate

Untersuchungen der chemischen und biologischen Eigenschaften des 99mTc-Methylendiphosphonats in der Knochenszin-tigraphie
N. Vanlić-Razumenić
1   From the Boris Kidrič Institute of Nuclear Sciences
,
D. Djokić
1   From the Boris Kidrič Institute of Nuclear Sciences
,
N. Paunković
2   Vinča, the Medical Center
,
D. Gorkić
3   Zaječar, and the School of Medicine, Beograd, Yugoslavia
› Institutsangaben
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Received: 24. Mai 1982

Publikationsdatum:
10. Januar 2018 (online)

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Studies of the chemical and biological properties as well as of the optimization of a 99mTc-MDP kit for clinical application have been performed. During the preparation of a Sn-MDP complex for labelling with 99mTc, the molar ratio of the reactants [MDP: Sn (II)], the concentration of the Sn-MDP complex and the pH of the 99mTc-MDP solution have been varied and their effects on biodistribution examined. The radiochemical composition of the labelled solutions was checked by paper chromatography, thin-layer chromatography and gel-filtration. The results of clinical applications for bone and early kidney imaging are also reported.

Es wurden die chemischen und biologischen Eigenschaften des 99mTc-MDP sowie seine Eignung für den klinischen Anwendungsbereich untersucht. Während der Herstellung des Sn-MDP-Komplexes für die Markierung mit 99mTc wurden die molaren Verhältnisse der Reagenzien [MDP: Sn (II)], die Konzentration des Sn-MDP-Komplexes und der pH-Wert der 99mTc-MDP-Lösung variiert und deren Einfluß auf die Bioverteilung untersucht. Die radiochemische Zusammensetzung der markierten Lösungen wurde durch Papierchromatographie, Dünnschichtchromatographie und Gelfiltration überprüft. Die Ergebnisse der klinischen Anwendung in der Knochenszintigraphie und der frühen Nierenszintigraphie werden dargelegt.

 

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