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Nuklearmedizin 1977; 16(01): 26-29
DOI: 10.1055/s-0037-1620602
Originalarbeiten – Original Articles
Schattauer GmbH

Effects of Preloading of Stannous Compounds on the Distribution of 99mTc-Pertechnetate[*]

L. F. Hathorn
1   From the Brookhaven National Laboratory Upton, New York
,
D. D. Greenberg
1   From the Brookhaven National Laboratory Upton, New York
,
P. Som
1   From the Brookhaven National Laboratory Upton, New York
,
G. E. Meinken
1   From the Brookhaven National Laboratory Upton, New York
,
D. F. Sacker
1   From the Brookhaven National Laboratory Upton, New York
,
H. L. Atkins
1   From the Brookhaven National Laboratory Upton, New York
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Received:09. September 1976

Publikationsdatum:
10. Januar 2018 (online)

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Summary

99mTc-pertechnetate distribution studies were performed in rabbits and mice following pretreatment between 5—336 hours with various routinely used stannous complexes (HSA, MAA, GHT, DTPA, PYPs) containing different amounts of Sn++ (0.17 —15.0 μ mg/kg). Beyond a concentration of 0.26 mg/kg of Sn++ an alteration in 99mTc-pertechnetate distribution was observed. The red blood cell was found to be the most prominent target. An in-vivo reduction of 99mTc-pertechnetate apparently occurred by the presence of stannous ion within the red blood cell. Preloading time period between 5—24 hours did not alter the uptake of RBC/plasma ratio. Beyond that period it decreased slowly and still persisted up to 2 weeks following pretreatment. RBC/ plasma ratio of 99mTcO4 - increased with increased Sn++ content of various commercially available pharmaceutical kits.

* Work performed under the auspices of the U.S. Energy Research and Development Administration.


 

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