Download PDF
Nuklearmedizin 1977; 16(02): 57-62
DOI: 10.1055/s-0037-1620606
Originalarbeiten – Original Articles
Schattauer GmbH

A Simple and Rapid Non-Invasive Radioisotope Method to Determine Ventricular Ejection Fractions and Cardiopulmonary Transit Times

J. Kuikka
1   From the Division of Nuclear Medicine (Head: A. Ahonen,) of the Department of Clinical Chemistry (Director: R. Vihko, Professor of Clinical Chemistry), University Central Hospital, Oulu, Finland
,
A. Ahonen
1   From the Division of Nuclear Medicine (Head: A. Ahonen,) of the Department of Clinical Chemistry (Director: R. Vihko, Professor of Clinical Chemistry), University Central Hospital, Oulu, Finland
› Author Affiliations
Further Information

Publication History

Received:08 November 1976

Publication Date:
10 January 2018 (online)

Also available at
    Permissions and Reprints

Summary

Ejection fractions and cardiopulmonary transit times were measured in 20 hospital patients by means of intravenously injected 99mTc-radiocardiography. Time activity curves from the regions of the whole heart, superior vena cava, right atrium, right ventricle, right lung, left atrium and left ventricle were drawn and analyzed by using the modified gamma function fitting method. The comparison between the ejection fractions determined from the whole heart curves and those from the ventricular curves shows a correlation coefficient of 0.93 for the right ventricle and of 0.90 for the left, although there was a systematic difference between the determinations. The analysis of the single ventricular curves gave about 10 per cent higher values than those obtained from the whole heart curves

The cardiopulmonary parameters measured from the whole heart curves for 16 normal subjects the following results gave:

right ventricular ejection fraction = 0.57 ± 0.08

left ventricular ejection fraction = 0.62 ± 0.08

pulmonary mean transit time = 6.1 ± 1.1 heart-beats

intracardiac mean transit time = 10.5 ± 1.8 heartbeats

right/left ventricular volume = 1.10 ± 0.09

These values agree closely with the data accumulated using more elaborate methods. The method presented here is simple to perform, it is non-invasive, time-saving, inexpensive, easy to analyze and suitable for exercising subjects and for bed-side measurements. Data assembly and analysis are easily automated so that results are obtainable immediately after measurements.

 

  • References

  • 1 Prinzmetal M, Corday E, Bergman H, Schwartz L, Spritzler R. Radiocardiography: a new method for studying the blood flow through the chambers of the heart in human beings. Science 1948; 108: 340
    CrossrefPubMedGoogle Scholar
  • 2 Donato L, Bianchi R, Giordani R. Recording and processing radiocardiograms for analog computer analysis. Radioactive Isotope in Klinik und Forschung 1963; 5: 27-42.
    Google Scholar
  • 3 Ishii Y, Maclntyre W. Analytical approach to dynamic radioisotope recording. J. Nucl. Med 1971; 12: 792-799.
    PubMedGoogle Scholar
  • 4 Berndt T, Alderman E, Wasnich R, Hsieh S, Van Dyke D, Harrison D. Evaluation of portable radionuclide method for measurment of left ventricular ejection fraction and cardiac output. J. nucl. Med 1975; 16: 289-292.
    PubMedGoogle Scholar
  • 5 Kuikka J. 113Inm radiocardiographic measurements of cardiopulmonary parameters in healthy subjects and in cardiac patients. (Ph. D. thesis) Department of Physics, University of Jyväskylä; Finland, Research Report: No. 2/1976
    Google Scholar
  • 6 Starmer C, Clark D. Computer computations of cardiac output using the gamma function. J. appl. Physiol 1970; 28: 219-220.
    CrossrefPubMedGoogle Scholar
  • 7 Donato L, Giuntini C, Lewis M, Durand J, Rochester D, Harwey R, Cournand A. Quantitative radiocardiogra-phy I. Theoretical considerations. Circulation 1962; 26: 174-182.
    PubMedGoogle Scholar
  • 8 De Vernejoul P, Delaloye B, Di Gregorio V, Kellershohn C. Mesure du débit cardiaque et des volumes ventricu-laires par radiocardiographie. Rev. franç. Étud. clin. biol 1964; 9: 693-715.
    PubMedGoogle Scholar
  • 9 Pierson R, Van Dyke D. Analysis of left “ventricular function. In Quantitative Nuclear cardiography Pierson R, Kriss J, Jones R, Maclntyre W. John Wiley & Sons. 1975: 123-154.
    Google Scholar
  • 10 Strauss H, Zaret B, Hurley P, Natarajan T, Bert-man P. A scintiphotographic method for measuring left ventricular ejection fraction in man without cardiac catheterization. Amer. J. Cardiol 1970; 28: 575-580.
    Google Scholar
  • 11 Parker J, Secker-Walker R, Hill R, Potchen E, Siegel R, Resnick L. The measurement of left ventricular ejection fraction using a scintillation camera and a small digital computer. J. nucl. Med 1972; 13: 459
    Google Scholar
  • 12 Roux G, Lansiart A, de Vernejoul P, Kellershohn C. Simulateur analogique électronique de radiocardiogrammes. Med. & Biol. Engin 1969; 7: 57
    Google Scholar
  • 13 Parker H, Van Dyke D, Uphamand F, Windsor A. Analog and digital simulation of the radiocardiogram. in Dynamic Studies with Radioisotopes in Medicine 1974, Proceedings of a Symposium, Knoxville 15-19 July, 1974, Vol. II p. 173-189.
    Google Scholar
  • 14 Heiskanen T. Analogue model for the analysis of radiocar-diograms. Cardiovasc. Res 1971; 5: 268-276.
    CrossrefPubMedGoogle Scholar
  • 15 Riihimäki E, Heiskanen A, Heiskanen T, Tähti E. A model for the analysis of radiocardiograms using a digital computer in time-sharing mode, in Dynamic Studies with Radioisotopes in Medicine 1974. Proceedings of a Symposium, Knoxville 15-19 July 1974; II: 165-171.
    Google Scholar
  • 16 Schicha H, Vyska K, Becker V, Feinendegen L. Ra-diocardiography of minimal transit times, in Dynamic Studies with Radioisotopes in Medicine 1974. Proceedings of a Symposium, Knoxville 15-19 July 1974; II: 193-204.
    Google Scholar