²⁰¹T1 for Myocardial Imaging

²⁰¹T1 is an agent which allows good quality myocardial imaging with the gamma-camera. Its distribution in the myocardium is related primarily to perfusion and myocardial cellular integrity. Redistribution into regions of decreased activity identifies ischemic myocardium whereas persistent reduction of regional activity occurs in areas of infarction. ²⁰¹T1 imaging appears to provide a means of differentiating between myocardial ischemia and infarction and is therefore applicable to exercise stress testing as well as to the acute coronary situation.

²⁰¹T1 ermöglicht eine qualitativ gute Darstellung des Myokards mit der Gamma-Kamera. Die Verteilung im Myocard ist in erster Linie abhängig von der Durchblutung und zellulären Integrität des Herzmuskels. Die Umverteilung von ²⁰¹T1 in Regionen verminderter Aktivitätsspeicherung ermöglicht die Erkennung ischämischer Myokardpartien, während eine anhaltende Aktivitätsverminderung im infarzierten Myokardbereich beobachtet wird. Mit Hilfe des ²⁰¹T1 können also Infarkt und vorübergehende Ischämie des Myokards unterschieden werden.

• References

• 1 Bailey I, Griffith L. S. C, Rouleau J, Strauss H. W, Pitt B. Thallium-201 myocardial perfusion imaging at rest and during exercise: Comparative sensitivity to electrocardiography in coronary artery disease. Circulation 1977; 55: 79.
• 2 Beller G. A, Pohost G. M. Mechanism for thallium-201 redistribution after transient myocardial ischemia. Circulation. 1977; Ill Suppl 140: 55-56. Abstract
• 3 Berman D. S, Salel A. F, Denardo G. L, Mason D. T. Noninvasive detection of regional myocardial ischemia using rubidium 81 and the scintillation camera. Comparison with stress electrocardiography in patients with arteriographically documented coronary stenosis. Circulation 1975; 52: 619.
• 4 Blood D. K, McCarthy D. M, Sciacca R. R, Cannon P. J. Comparison of Thallium-201 myocardial scans at rest with scans four hours after exercise. Circulation 1977; 229 Suppl Ill: 55-56. Abstract
• 5 Bradley-Moore P. R, Lebowirz E, Greene M. W, Atkins H. L, Ansari A. N. Thallium-201 for medical use. II. Biological behavior. J. nucl. Med 1975; 16: 160.
• 6 Britten J. S, Blank M. Thallium activation of the (Na⁺ - K+) - activated ATPase of rabbit kidney. Biochem. bio-phys. Acta 1968; 159: 160.
• 7 Bulkley B. H, Rouleau J, Strauss H. W, Pitt B. Sarcoid heart disease: Diagnosis by thallium-201 myocardial perfusion imaging. Amer. J. Cardiol 1976; Abstract 37: 125.
• 8 Bulkley B. H, Hutchings G. M, Bailey I, Strauss H. W, Pitt B. Thallium-201 imaging and gated cardiac blood pool scans in patients with ischemic and congestive cardiomyopathy: A clinical and pathologic study. Circulation 1977; 55: 753.
• 9 Buja L. M, Parkey R. W, Stokely E. M, Boute F. J, Willerson J. J. Pathophysiology of technetium-99m stannous pyrophosphate and thallium-201 scintigraphy of acute anterior myocardial infarcts in dogs. J. clin. Invest 1976; 57: 1508.
• 10 Cook D. J, Bailey I, Strauss H. W. Thallium-201 for myocardial imaging: Appearance of the normal heart. J. nucl. Med 1976; 17: 583.
• 11 Gewirtz H, Beller G. A, Zir L. M, Pohost G. M. Transient defects on resting thallium scans in patients with coronary artery disease. (Manuscript in preparation)
• 12 Holman B. L. Radionuclide methods in the evaluation of myocardial ischemia and infarction. Circulation 1976; 53 I Suppl 1-112.
• 13 Hör G, Sebenjng H, Sauer E, Lichte H, Dressler J, Lu-tilsky L, Wagner-Manslau C, Pabst H. W. Thallium-201 redistribution in coronary heart disease. Early and delayed myocardial scans. J. Nucl. Med 1977; 18: 599.
• 14 Lebowitz E, Greene M. W, Fairchild R, Bradley-Moore P. R, Atkins H. L, Richards P, Belgrave E. Thallium-201 for medical use. J. Nucl. Med 1975; 16: 151.
• 15 Maseri A, Parodi O, Severi S, Pesola A. Transient transmural reduction of myocardial blood flow, demonstrated by thallium-201 scintigraphy, as a cause of variant angina. Circulation 1976; 54: 280.
• 16 Mueller T. M, Marcus M. L, Ehrhardt J. C, Chauduri T, Abboud F. M. Limitations of thallium-201 myocardial scintigrams. Circulation 1976; 54: 640.
• 17 Osborn R. C, Smitherman T. C. Differentiation of transiently ischemic from infarcted myocardium following acute myocardial ischemia in man by serial myocardial scintigraphy following a single dose of thallium-201. (Abstract). Clin. Res. (1977, in press).
• 18 Pohost G. M, Zir L. M, Moore R. H, McKusick K. A, Guiney T. E, Beller G. A. Differentiation of transiently ischemic from infarcted myocardium by serial imaging after a single dose of thallium-201. Circulation 1977; 55: 294.
• 19 Pohost G. M, McKusick K. A, Dinsmore R. E, Zir L. M, Guiney T. E, Beller G. A. Redistribution of thallium-201 during sequential myocardial imaging after exercise: Relationship to coronary artery disease and wall motion abnormalities. Clin. Res 25: 244 1977; Abstract
• 20 Pond M, Rehn T, Burow R, Pitt B. Early detection of myocardial infarction by serial thallium-201 imaging. Circulation 1977; 230 Suppl III: 55-56. Abstract
• 21 Ritchie J, Zaret B, Strauss H. W, Pitt B, Berman D. S, Schelbert H, Ashburn W, Berger H, Hamilton C. Myocardial imaging with thallium-201 at rest and exercise - a multicenter study. Circulation 1977; 230 III Suppl 55-56.
• 22 Ritchie J. L, Trobaugh G. B, Hamilton G. W, Gould K. L, Narahara K. A, Murray J. A, Williams D. L. Myocardial imaging with thallium-201 at rest and during exercise: Comparison with coronary arteriography and resting and stress electrocardiography. Circulation 1977; 56: 67.
• 23 Schelbert H, Schuler G, Ashburn N, Covell J. Time course of redistribution of thallium-201 after transient ischemia. J. nucl. Med 1977; 18: 598 Abstract
• 24 Schelbert H, Ingwall J, Watson R, Ashburn W. Factors influencing the myocardial uptake of thallium-201. J. nucl. Med 1977; 18: 598 Abstract
• 25 Strauss H. W, Harrison K, Langan J. K. et al. Thallium-201 for myocardial imaging Relation of thallium-201 to regional myocardial perfusion. Circulation 1975; 51: 641.
• 26 Strauss H. W. Cardiovacular nuclear medicine: A new look at an old problem. Radiology 1976; 121: 257.
• 27 Wackers F. J, Sokole E. B, Samson G, van der Schoot J. B, Lie K. I, Liem K. L, Wellens H. J. Value and limitations of thallium-201 scintigraphy in acute phase of myocardial infarction. New Engl. J. Med 1976; 295: 1.
• 28 Wackers F. J, Becker A. E, Samson G, Sokole E. B, van der Schoot J. B, Vet A. J, Lie K. I, Durrer D, Wellens H. J. Location and size of acute transmural myocardial infarction estimated from thallium-201 scintiscans: A clinopa-thologic study. Amer. J. Cardiol 1977; 56: 72.
• 29 Wackers R. J, Lie K. I, Liem K. L, Sokole E. B, Samson G, van der Schoot H, Wellens H. J, Durrer D. Thallium-201 scintigraphy in unstable angina. J. nucl. Med 1977; 18: 594.
• 30 Zaret B. L, Strauss H. W, Martin N. D, Wells H. P, Flamm M. D. Noninvasive regional myocardial perfusion with radioactive potassium. New Engl. J. Med 1973; 288: 809.
• 31 Zaret B. L. Myocardial imaging with radioactive potassium and its analogs. Progr. cardiovasc. Dis 1977; 20: 81.