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Nuklearmedizin 1981; 20(01): 30-34
DOI: 10.1055/s-0037-1620713
Originalarbeiten – Original Articles
Schattauer GmbH

Detection of Abscesses and Lymphosarcoma with 111In-Deferoxamine Mesylate

Untersuchungen von Abszessen und Lymphosarkom mit 111In-Deferoxamin Mesylat
I.C. Dormehl
1   From the Dept. of Life-Sciences, Atomic Energy Board, South Africa
,
D.J. Goosen
2   H.A. Grové Animal Research Centre, South Africa
,
J.H. Jordaan
1   From the Dept. of Life-Sciences, Atomic Energy Board, South Africa
,
N.J. Laage
3   H. F. Verwoerd Hospital, Pretoria, South Africa
,
M. Maree
1   From the Dept. of Life-Sciences, Atomic Energy Board, South Africa
› Author Affiliations
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Publication History

Received: 09 September 1980

Publication Date:
09 January 2018 (online)

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Indium-111-deferoxamin wurde zum Nachweis sowohl induzierter Abszesse unterschiedlichen Alters in einem Pavian als auch der Lymphknoten in einem Fall von spontanem Lymphosarkom bei Hunden mittels Gamma-Szintigraphie nachzuweisen. Positive Resultate wurden bereits 1 Std. nach der Verabreichung erzielt; das Verhältnis von Target zu Hintergrund verbesserte sich ständig im Laufe der Zeit. Die Gewebeverteilung des Radiopharmakons wurde bei Ratten bestimmt und eine relativ hohe Isotopenkonzentration in den Nieren beobachtet.

Indium-111-deferoxamine was used to delineate induced abscesses of different ages in a baboon, and lymphnodes in a case of canine spontaneous lymphosarcoma, by means of gamma-scintigraphy. Positive results were obtained already 1 hr after administration of the scanning agent, and the lesion-to-background ratio improved progressively with time. The tissue distribution of the radiopharmaceutical was determined in rats, and showed a relatively high isotope retention in the kidneys.

 

  • References

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