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Nuklearmedizin 1981; 20(02): 82-84
DOI: 10.1055/s-0037-1620721
Originalarbeiten – Original Articles
Schattauer GmbH

Response of Adrenal Catecholamine to a Newly Synthesized Chemical Radioprotector

Reaktion des Nebennieren-Katecholamins auf eine neuentwickelte Strahlenschutzverbindung
S. S. Hasan
1   From the Surgical Research Laboratory, Institute of Medical Sciences and the Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India
,
S. Mazumdar
1   From the Surgical Research Laboratory, Institute of Medical Sciences and the Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India
,
P.M. Singh
1   From the Surgical Research Laboratory, Institute of Medical Sciences and the Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India
,
S.N. Pandey
1   From the Surgical Research Laboratory, Institute of Medical Sciences and the Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi, India
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Received 02 February 1981

Publication Date:
10 January 2018 (online)

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This study was undertaken to try a newly synthesized compound (1-acetyl hydrazinyl thiophenyl formamidine dihydro-chloride) as a chemical radioprotector and to observe its effects on adrenal catecholamine and protein bound iodine (PBI). After whole-body irradiation, the catecholamine and serum PBI levels decreased significantly but treatment with the drug before irradiation increased the same. The whole-body irradiation resulted in a 50% mortality within a fortnight whereas the use of the drug prevented it.

Diese Untersuchung wurde unternommen, um eine neu synthetisierte Verbindung (1-Azetyl Hydrazinyl Thiophenyl Formamidin Dihydrochlorid) als strahlenschützende Substanz zu prüfen und ihren Effekt auf Nebennierenrinden-Katecholamin und das eiweißgebundene Jod (PBI) zu beobachten. Nach einer Ganzkörperbestrahlung sanken die Katecholamin- und Serum-PBI-Spiegel signifikant, während die Verabreichung der Verbindung vor der Bestrahlung sie dagegen erhöhte. Die Ganzkörperbestrahlung bewirkte eine 50%ige Mortalität innerhalb von zwei Wochen, während die Verwendung dieser Verbindung dies verhinderte.

 

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