The Fate of Intravenously Injected Radiogold Adsorbed onto Carbon Particles and its Possible Applications^[*]

Summary

Following the intravenous injection of auric chloride-¹⁹⁸Au adsorbed onto carbon particles in dogs, the radioactivity disappeared from the circulation very rapidly to collect in the lung which contained 97.6% ± 1.3 of the injected dose. This amount was evenly distributed between the right and left lungs with a higher tendency to localization in the basal regions.

The almost total extraction of the radioactive material by the lungs made it possible to obtain good photoscan pictures for these organs.

As regards the fate of the carbon particles, it was shown that they were ultimately discharged through the bronchial tree.

Lastly, radiogold on carbon was used to investigate the problem of stream line flow in the portal venous system. The obtained results prove beyond doubt the absence of constant portal stream lining in dogs.

Résumé

Des chiens ont été injectés avec du ¹⁹⁸Au chlorure adsorbé sur des particules de charbon. On a constaté que la radioactivité diparut assez vite de la circulation afin de concentrer à 97.6 ± 1.3 de la dose totale dans les poumons. L’équipartition de cette quantité dans les deux poumons se montra avec une tendance de fixation plus élevée dans les régions basales.

L’extraction presque totale du materiel radioactif par les poumons permit d’obtenir de bons images par photoscan de ces organes.

Quant aux particules de charbon il s’est montré qu’à la fin ils furent éliminés par voie de l’arbre bronchique.

Enfin, le ¹⁹⁸Au chlorure fut appliqué pour examiner l’écoulement laminaire dans le système portai. Les résultats obtenus ne laisssent aucun doute que, chez des chiens, un écoulement laminaire constant dans le système portai n’existe pas.

Zusammenfassung

An Kohlepartikeln hängendes ¹⁹⁸Au-Chlorid wurde Hunden i.v. injiziert. Die Radioaktivität konzentrierte sich sehr schnell in der Lunge, und zwar mit 97,6 ± 1,3 der injizierten Dosis. Die Radioaktivität war gleichmäßig auf beide Lungenhälften verteilt mit einer Tendenz zur stärkeren Speicherung in den Basalregionen.

Die fast vollständige Aufnahme des radioaktiven Materials in der Lunge erlaubte gute Darstellungen dieses Organs durch Photoscan.

Die Kohlepartikel ihrerseits wurden schließlich über den Bronchialbaum ausgeschieden.

Darüber hinaus wurde Radiogold auf Kohlepartikeln zur Untersuchung des Unterschichtungsphänomens im Pfortadersystem verwendet. Die Ergebnisse lassen keinen Zweifel daran, daß bei Hunden keine konstante Unterschichtungsströmung im Pfortadersystem besteht.

^* This work was partly presented in The First Afro-Asian Medical Congress, Cairo, October 1964.

^* Done under contract # MU / MR / 64—1.

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