Fate of ¹³¹I-Phenylstearic Acid and ¹³¹I-Oleic Acid after Intravenous and Oral Administration

Summary

A comparative study of the fates of ¹³¹I-phenylstearic and ¹³¹I-oleic acids, administered orally and intravenously to albino rats, has been made. Because of its higher stability against in vivo deiodination and its good absorption in the intestinal tract, the ¹³¹I-phenylstearic acid has been adjudged superior to the ¹³¹I-oleic acid for studies of intestinal fat absorption.

Une étude comparative des distributions de l’acide phényle-stéarique et de l’acide oléique marqués à ¹³¹I et administrés par la voie orale et intraveneuse aux rats albinos fut executée. L’acide ¹³¹I-phényle - stéarique est jugé superieure à l’acide ¹³¹I-oléique pour les études de l’absorption intestinale des lypides parceque son absorption intestinale est très bonne est sa stabilité in vivo contre déiodination est plus grande.

An Albinoratten wurden Untersuchungen über die Verteilung von ¹³¹J-Phenylstearin- und ¹³¹J-Oleinsäure nach peroraler und intravenöser Verabreichung durchgeführt.

Wegen der größeren Stabilität in vivo, in bezug auf Jodabspaltung und Absorption im Darm, scheint für das Studium der Fettabsorption die ¹³¹J-Phenylstearinsäure besser geeignet zu sein als die ¹³¹J-Oleinsäure.

^* Present address: The Johns Hopkins Medical Institutions Department of Radiological Science Baltimore, Maryland, USA.

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