Combined haplotypes of protein C and endothelial protein C receptor

A. Binder; M. Müller; B. Resch; C. Mannhalter; W. Zenz

doi:10.1055/s-0037-1621493

Hämostaseologie, Table of Contents

Hamostaseologie 2009; 29(S 01): S108-S109
DOI: 10.1055/s-0037-1621493

Communication

Schattauer GmbH

Combined haplotypes of protein C and endothelial protein C receptor

Association with outcome, purpura fulminans, and susceptibility in children with meningococcaemiaKombinierte Haplotypen von Protein C und endothelialen Protein-C-RezeptorAssoziation mit Outcome, Purpura fulminans und Suszeptibilität bei Kindern mit systemischer Meningokokken-erkrankung

A. Binder^*

¹Dept. of General Paediatrics, Medical University of Graz

,

M. Müller

¹Dept. of General Paediatrics, Medical University of Graz

,

B. Resch

³Dept. of Neonatology, Medical University of Graz, Austria

,

C. Mannhalter

²Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Vienna, Austria

,

W. Zenz^*

¹Dept. of General Paediatrics, Medical University of Graz

› Author Affiliations

Abstract

Full Text

References

References
1 Achtmann M. Global epidemiology of meningococcal disease. In: Cartwright K. ed. Meningococcal disease. Chichester: John Wiley & Sons; 1995: 159-177.
2 Zenz W, Zoehrer B, Levin M. et al. Use of recombinant tissue plasminogen activator in children with meningococcal purpura fulminans: A retrospective study. Crit Care Med 2004; 32: 1777-1780.
3 Leclerc F, Hazelzet J, Jude B. et al. Protein C and S deficiency in severe infectious purpura of children: a collaborative study of 40 cases. Intensive Care Med 1992; 18: 202-205.
4 Kato A, Miura O, Sumi Y, Aoki N. Assignment of the human protein C gene (PROC) to chromosome region 2q14----q21 by in situ hybridization. Cytogenet Cell Genet 1988; 47: 46-47.
5 Scopes D, Berg LP, Krawczak M. et al. Polymorphic variation in the human protein C (PROC) gene promoter can influence transcriptional efficiency in vitro. Blood Coagul Fibrinolysis 1995; 6: 317-321.
6 Spek CA, Greengard JS, Griffin JH. et al. Two mutations in the promoter region of the human protein C gene both cause type I protein C deficiency by disruption of two HNF-3 binding sites. J Biol Chem 1995; 270: 24216-24221.
7 Powars DR, Rogers ZR, Patch MJ. et al. Purpura fulminans in meningococcemia: association with acquired deficiencies of proteins C and S. N Engl J Med 1987; 317: 571-572.
8 Brandtzaeg P, Sandset PM, Joo GB. et al. The quantitative association of plasma endotoxin, antithrombin, protein C, extrinsic pathway inhibitor and fibrinopeptide A in systemic meningococcal disease. Thromb Res 1989; 55: 459-470.
9 Fijnvandraat K, Derkx B, Peters M. et al. Coagulation activation and tissue necrosis in meningococcal septic shock: severely reduced protein C levels predict a high mortality. Thromb Haemost 1995; 73: 15-20.
10 Medina P, Navarro S, Estelles A. et al. Influence of the 4600A/G and 4678G/C polymorphisms in the endothelial protein C receptor (EPCR) gene on the risk of venous thromboembolism in carriers of factor V Leiden. Thromb Haemost 2005; 94: 389-394.
11 Saposnik B, Reny JL, Gaussem P. et al. A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis. Blood 2004; 103: 1311-1318.
12 Binder A, Endler G, Muller M. et al. 4G4G genotype of the plasminogen activator inhibitor-1 promoter polymorphism associates with disseminated intravascular coagulation in children with systemic meningococcemia. J Thromb Haemost 2007; 5: 2049-2054.