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Phlebologie 2012; 41(02): 77-88
DOI: 10.1055/s-0037-1621805
Originalarbeit
Schattauer GmbH

Sclerotherapy using air- or CO2-O2-foam

Post-approval study Artikel in mehreren Sprachen: deutsch | English
G. Hesse
,
F. X. Breu
,
A. Kuschmann
,
K. Hartmann
4   Venenzentrum Freiburg
,
N. Salomon
› Institutsangaben
Weitere Informationen

Publikationsverlauf

eingereicht:11. Dezember 2011

angenommen:02. Januar 2012

Publikationsdatum:
30. Dezember 2017 (online)

    Lizenzen und Reprints

Summary[*]

Introduction: This multicentre observational study (OS) documented the efficacy and side-effects of ultrasound-guided polidocanol foam sclerotherapy (FS) of air and carbon dioxide / dioxygen foam (CO2-O2 FS) using the same evaluation protocol in each centre.

Material and Methods: Eleven centers participated in this OS, nine centers worked with air-based FS, two with CO2-O2 FS. Only approved drugs were used. In 376 patients undergoing 553 treatments, air-based FS was performed using 0.25 % to 4 % polidocanol microfoam (Aethoxysklerol®, Kreussler). 125 patients in 152 sessions were treated with CO2-O2-based foam using 1 % to 3 % polidocanol with seven parts CO2 (Laparox®, Linde) to three parts O2 (Conoxia®, Linde). For the sterile dispensing of the CO2-O2 FS a mass flow controller was used. Efficacy of treatment and side effects were assessed clinically and with duplex examination in the following visit and 4–6 weeks after the last session.

Results: Varicose veins larger than 3 mm were treated with an average volume of 5.3 ml in the air-FS and 8.2 ml in the CO2-O2 FS, p<0.0001. In the CO2-O2-group clinical appearance, and venous occlusion rate documented by Duplex treatment was slightly more efficient, most likely because larger volumes could be safely applied. In the CO2-O2 group compression therapy was performed in 97.6 % of the cases, in the air group and in 75.2 % significant (p=0.01).

In general more side effects occurred after air in comparison with CO2-O2 the differences were significant (p<0.0001) for: hyperpigmentation 23.3 %/13.6%, and he-matoma 14.4 %/2.5 %.

The differences were not significant for: Migrane 0.1 %/0 %, Matting 1.4 %/0 %, Burning sensation 11.7 %/5.5 %, Thrombosis 1.1 %/1.6 %, Visual impairment 0.2 %/2,0 %.

Keywords

CO2O2-Foam-Sclerotherapy - Air-Foam-Sclerotherapy - Efficiency - Side-effects - Visual side-effects
 

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