Blutgerinnungsfaktor XIII: Aktivierung, Substrate und Struktur einer Transglutaminase

T. Sicker; R. Hilgenfeld

doi:10.1055/s-0037-1622011

Hämostaseologie, Table of Contents

Hamostaseologie 2002; 22(01): 08-13
DOI: 10.1055/s-0037-1622011

Original Article

Schattauer GmbH

Blutgerinnungsfaktor XIII: Aktivierung, Substrate und Struktur einer Transglutaminase

Blood coagulation factor XIII: Activation, substrates and structure of a transglutaminase

T. Sicker

,

R. Hilgenfeld

Institut für Molekulare Biotechnologie, Jena

› Author Affiliations

Abstract

Zusammenfassung

Der Blutgerinnungsfaktor XIII wurde lange Zeit wenig beachtet, und die Forschung auf dem Gebiet der Transglutaminasen wurde vernachlässigt. Durch die interessanten Ergebnisse der vergangenen Jahre wird jedoch deutlich, wie wichtig dieses Protein für den dauerhaften Wundverschluss ist. Auch wenn Feinregulation von Aktivierung und lokal begrenzter Aktivität noch nicht vollständig verstanden sind, zeigen die bereits gefundenen Mechanismen einen hohen Grad an Komplexität. In dieser übersicht werden jüngste biochemische und strukturelle Ergebnisse zum Faktor XIII diskutiert.

Summary

For a long time blood coagulation factor XIII did not get the attention it deserves, and research in the field of transglutaminases was neglected. The interesting results obtained in recent years demonstrate the importance of this protein for the stabilization of a blood clot. The accurate regulation of activation and of localization of factor XIII is not fully understood. Yet the proposed mechanisms suggest a high degree of complexity. In this review, recent biochemical and structural results on factor XIII are discussed.

Schlüsselwörter

Faktor XIII - Blutgerinnung - Transglutaminase

Keywords

Factor XIII - blood coagulation - transglutaminase

Full Text

References

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