Osteologie 2017; 26(02): 62-66
DOI: 10.1055/s-0037-1622095
Knochenmarködemsyndrom
Schattauer GmbH

Einteilung der Knochenmarködeme

Categorisation of bone marrow syndromes
U. Maus
1   Klinik für Orthopädie und spezielle Orthopädie, Universitätsklinik für Orthopädie und Unfallchirurgie, Pius Hospital, Carl-von-Ossietzky Universität Oldenburg, Oldenburg
,
J. Beckmann
2   Sportklinik Stuttgart, Stuttgart
› Author Affiliations
Further Information

Publication History

eingereicht: 21 April 2017

angenommen: 25 April 2017

Publication Date:
02 January 2018 (online)

Zusammenfassung

Das Knochenmarködemsyndrom ist eine selbstlimitierende Erkrankung mit einem Verlauf über einen Zeitraum von bis zu 24 Monaten. Die schmerzhafte Erkrankung betrifft überwiegend Hüft-, Knie- und Sprunggelenk und wird mittels MRT nachgewiesen. Abzugrenzen sind Knochenmarködeme aufgrund anderer Ursache, da die korrekte Erfassung der Ätiologie auch für die Therapieentscheidung eine wesentliche Rolle spielt. Die Knochenmarködeme können unterschiedlich eingeteilt werden, wobei eine Einteilung lediglich nach der Lokalisation eine Therapieentscheidung nicht ermöglicht. Daher hat sich mittlerweile die Einteilung in mechanische, ischämische und reaktive/posttraumtische Knochenmarködeme durchgesetzt. In dem vorliegenden Beitrag sollen die verschiedenen Formen der Knochenmarködeme und des Knochenmarködemsyndroms dargestellt und die wesentlichen Kriterien zur Unterscheidung erläutert werden.

Summary

Bone marrow edema syndrome is a self-limiting disease, with a spontaneous resolution in up to 24 months. The bone marrow syndrome mostly affects middle-aged men with an age between 30 and 50 years, or women in the third trimester of pregnancy. The painful disease is often localised hip, knee or ankle joint. Magnetic resonance imaging (MRI) shows large homogenous bone marrow edema involving the femoral head and sometimes the femoral neck. A possible evolution in toward an osteonecrosis is still debated, the differentiation is sometimes challenging. Bone marrow edema is also described with other clinical entities, which are all characterized by the same findings in MRI. But the differentiation in different etiologies is clinical relevant for the decision about the therapy. The classification by different localizations is not useful for the clinical situation and therapy decision. Most authors prefer a diversification in mechanical, ischaemic and reactive or posttraumatic causes. The current article shows different kinds of bone marrow edema and bone marrow edema syndrome and explains the relevant criteria for differentiation.

 
  • Literatur

  • 1 Breitenseher MJ, Kramer J, Mayerhoefer ME, Aigner N, Hofmann S. [Differential diagnosis of bone marrow edema of the knee joint]. Radiologe 2006; 46 (01) 46-54.
  • 2 Karantanas AH, Drakonaki E, Karachalios T. et al. Acute non-traumatic marrow edema syndrome in the knee: MRI findings at presentation, correlation with spinal DEXA and outcome. Eur J Radiol 2008; 67 (01) 22-33.
  • 3 Korompilias AV, Karantanas AH, Lykissas MG, Beris AE. Bone marrow edema syndrome. Skeletal Radiol 2009; 38 (05) 425-436.
  • 4 Disch AC, Matziolis G, Perka C. The management of necrosis-associated and idiopathic bone-marrow oedema of the proximal femur by intravenous iloprost. J Bone Joint Surg Br 2005; 87 (04) 560-564.
  • 5 Plenk Jr. H, Hofmann S, Eschberger J. et al. Histomorphology and bone morphometry of the bone marrow edema syndrome of the hip. Clin Orthop Relat Res 1997; 334: 73-84.
  • 6 Balakrishnan A, Schemitsch EH, Pearce D, McKee MD. Distinguishing transient osteoporosis of the hip from avascular necrosis. Can J Surg 2003; 46 (03) 187-192.
  • 7 Doury P. Bone-marrow oedema, transient osteoporosis, and algodystrophy. J Bone Joint Surg Br 1994; 76 (06) 993-994.
  • 8 Baier C, Schaumburger J, Gotz J. et al. Bisphosphonates or prostacyclin in the treatment of bonemarrow oedema syndrome of the knee and foot. Rheumatol Int 2013; 33 (06) 1397-1402.
  • 9 Sun W, Shi Z, Gao F. et al. The pathogenesis of multifocal osteonecrosis. Scientific reports 2016; 06: 29576.
  • 10 Hofmann S, Kramer J, Breitenseher M. et al. [Bone marrow edema in the knee. Differential diagnosis and therapeutic possibilities]. Orthopade 2006; 35 (04) 463-475 quiz 76–77.
  • 11 Quack V, Betsch M, Schenker H. et al. [Pathophysiology of traumatic bone marrow edema]. Unfallchirurg 2015; 118 (03) 199-205.
  • 12 Fayad LM, Kamel IR, Kawamoto S. et al. Distinguishing stress fractures from pathologic fractures: a multimodality approach. Skeletal Radiol 2005; 34 (05) 245-259.
  • 13 Krampla W, Mayrhofer R, Malcher J. et al. MR imaging of the knee in marathon runners before and after competition. Skeletal Radiol 2001; 30 (02) 72-76.
  • 14 Patel DS, Roth M, Kapil N. Stress fractures: diagnosis, treatment, and prevention. Am Fam Physician 2011; 83 (01) 39-46.
  • 15 Kozoriz MG, Grebenyuk J, Andrews G, Forster BB. Evaluating bone marrow oedema patterns in musculoskeletal injury. Br J Sports Med 2012; 46 (13) 946-953.
  • 16 Sanders TG, Medynski MA, Feller JF, Lawhorn KW. Bone contusion patterns of the knee at MR imaging: footprint of the mechanism of injury. Radiographics 2000; 20: S135-S151.
  • 17 Craiovan BS, Baier C, Grifka J. et al. [Bone marrow edema syndrome (BMES)]. Orthopade 2013; 42 (03) 191-204.
  • 18 Hadji P, Boekhoff J, Hahn M. et al. Pregnancy-associated transient osteoporosis of the hip: results of a case-control study. Archives of osteoporosis 2017; 12 (01) 11.
  • 19 Hofmann S, Kramer J, Vakil-Adli A. et al. Painful bone marrow edema of the knee: differential diagnosis and therapeutic concepts. Orthop Clin North Am 2004; 35 (03) 321-333 ix.
  • 20 Starr AM, Wessely MA, Albastaki U. et al. Bone marrow edema: pathophysiology, differential diagnosis, and imaging. Acta Radiol 2008; 49 (07) 771-786.
  • 21 Kramer J, Breitenseher M, Imhof H. et al. [Diagnostic imaging in femur head necrosis]. Orthopade 2000; 29 (05) 380-388.
  • 22 Bohndorf K, Beckmann J, Jager M. et al. [S3 Guideline. Part 1: Diagnosis and Differential Diagnosis of Non-Traumatic Adult Femoral Head Necrosis]. Z Orthop Unfall 2015; 153 (04) 375-386.
  • 23 Beckmann J, Roth A, Niethard C. et al. [Bone marrow edema and atraumatic necrosis of the femoral head: Therapy]. Orthopade 2015; 44 (09) 662-671.
  • 24 Hofmann S, Schneider W, Breitenseher M. et al. [“Transient osteoporosis” as a special reversible form of femur head necrosis]. Orthopade 2000; 29 (05) 411-419.
  • 25 Felson DT, McLaughlin S, Goggins J. et al. Bone marrow edema and its relation to progression of knee osteoarthritis. Ann Intern Med 2003; 139 (5 Pt 1): 330-336.
  • 26 Manara M, Varenna M. A clinical overview of bone marrow edema. Reumatismo 2014; 66 (02) 184-196.
  • 27 Nakamura N, Horibe S, Nakamura S, Mitsuoka T. Subchondral microfracture of the knee without osteonecrosis after arthroscopic medial meniscectomy. Arthroscopy 2002; 18 (05) 538-541.
  • 28 Tillmann FP, Jager M, Blondin D. et al. Intravenous iloprost: a new therapeutic option for patients with post-transplant distal limb syndrome (PTDLS). Am J Transplant 2007; 07 (03) 667-671.