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Tierarztl Prax Ausg K Kleintiere Heimtiere 2004; 32(02): 67-70
DOI: 10.1055/s-0037-1622397
Allgemeines
Schattauer GmbH

Vor- und Nachteile synthetischer versus xenogener Knochenersatzmaterialien

Advantages and disadvantages of synthetic versus xenogen bone-grafts
G. Hauschild
1   Aus der Klinik für kleine Haustiere (Direktor Prof. Dr. I. Nolte) der Tierärztlichen Hochschule Hannover und dem
,
A. Bader
2   Biotechnologisch-Biomedizinischen Zentrum Leipzig, Organ- und Gewebekulturen (Leiter: Prof. Dr. A. Bader) der Universität Leipzig
› Author Affiliations
Further Information

Publication History

Publication Date:
05 January 2018 (online)

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Zusammenfassung:

Die Entwicklung von Knochenersatzstoffen ist in den letzten Jahren insbesondere im Bereich der reinen Gerüstsubstanzen weit fortgeschritten. Neben vollsynthetischen Produkten finden vor allem Xenotransplantate, meist auf boviner Basis, Verwendung. Vor dem Hintergrund bestehender möglicher Übertragungswege des Erregers der bovinen spongiformen Enzephalopathie auf andere Spezies sowie den Menschen und die Auslösung der Creutzfeld-Jakob-Krankheit durch diesen Erreger erfolgt eine Gegenüberstellung der Vor- und Nachteile synthetischer und xenogener Knochenersatzmaterialien. Risiken beim Einsatz von Xenotransplantaten auf boviner Basis werden diskutiert.

Summary:

Development of artificial bone grafts has increasingly progressed in the last few years. Significant progress has thereby been made in development, preclinical testing and clinical use of different matrices. In addition to complete synthetically manufactured products, xenografts based on bovine material are in wide spread clinical use. Possible transmission of prions causing bovine spongiform encephalopathia and Creutzfeld-Jakob disease give the background for discussing the advantages and disadvantages of synthetic versus xenografts. Possible risks using xenografts based on bovine material are discussed.

Schlüsselwörter

Knochenersatzmaterial - Xenotransplantat - Creutzfeldt-Jakob-Krankheit - Proteine

Key words

Bone-grafts - Xenografts - Creutzfeldt-Jakob disease - Proteins
 

  • Literatur

  • 1 Ärztezeitung. Berlin verbietet Arzneien aus Rindermaterial. Ärztezeitung. 24.01.2001; Redaktion.
    PubMedGoogle Scholar
  • 2 Ärztezeitung. Nahtmaterial aus Rinderdarm soll strikt verboten werden. Ärztezeitung. 09.02.2001; Redaktion.
    PubMedGoogle Scholar
  • 3 Artzi Z, Nemcovsky CE, Tal H. Efficacy of porous bovine bone mineral in various types of osseous deficiencies: clinical observations and literature review. Int J Periodontics Restorative Dent 2001; 21: 395-405.
    PubMedGoogle Scholar
  • 4 Brown P, Rau EH, Johnson BK. et al. New studies on the heat resistance of hamster-adapted scrapie agent: threshold survival after ashing at 600 degrees C suggests an inorganic template of replication. Proc National Academy of Sciences of the United States of America 2000; 97, 07: 3418-21.
    PubMedGoogle Scholar
  • 5 Bruder SP, Fox BS. Tissue engineering of bone. Clin Orthop Rel Res 1999; 367: 68-83.
    CrossrefPubMedGoogle Scholar
  • 6 Bucholz RW, Carlton A, Holmes RE. Hydroxyapatite and tricalcium phosphate bone graft substitutes. Orthop Clin North Am 1987; 18: 323-34.
    PubMedGoogle Scholar
  • 7 Collinge J. Variant Creutzfeldt Jakob disease. Lancet 1999; 354 (9175): 317-23.
    CrossrefPubMedGoogle Scholar
  • 8 Dillner L. BSE linked to new variant of CJD in humans. Br Med J 1996; 312 (7034): 795.
    CrossrefPubMedGoogle Scholar
  • 9 Dormont D. Agents that cause transmissible subacute spongiform encephalopathies. Biomed Pharmacother 1999; 53: 3-8.
    CrossrefPubMedGoogle Scholar
  • 10 Fleming Jr. JE, Cornell Jr. CN, Muschler GF. Bone cells and matrices in orthopedic tissue engineering. Orthop Clin North Am 2000; 31 (03) 357-74.
    CrossrefPubMedGoogle Scholar
  • 11 Gruber AJ. Erfahrungen mit Cerasorb® in der Praxis des niedergelassenen Chirurgen. Der niedergelassene Chirurg 1999.
    PubMedGoogle Scholar
  • 12 Foitzik C, Staus H. Phasenreines 14β-Tricalciumphosphat zum Knochenersatz bei parodontaler Indikation. Quintessenz 1999; 10: 1049-58.
    PubMedGoogle Scholar
  • 13 Hallmann M, Lundgren S, Sennerby L. Histologic analysis of clinical biopsies taken 6 months and 3 years after maxillary sinus floor augmentation with 80% bovine hydroxylapatite and 20% autogenous bone mixed with fibrin glue. Clin Implant Dent Relat Res 2001; 03 (02) 87-96.
    CrossrefPubMedGoogle Scholar
  • 14 Heide H, Karbe E, Kling HG. et al. Entwicklung und tierexperimentelle Untersuchungen von implantierbaren, porösen keramischen Werkstoffen. Zwei Teilberichte für das Bundesministerium für Forschung und Technologie; Bonn, Referat III B: 1973. 3,7/12.
    Google Scholar
  • 15 Hoenig JF, Merten HA, Heinemann DE. Risk of transmission of agents associated with Creutzfeldt-Jakob disease and bovine spongiform encephalopathy. Plast Reconstr Surg 1999; 103: 1324-5.
    CrossrefPubMedGoogle Scholar
  • 16 Hope J, Wood SC, Birkett CR. et al. Molecular analysis of ovine prion protein identifies similarities between BSE and an experimental isolate of natural scrapie. J Gen Virol 1999; 80: 1-4.
    CrossrefPubMedGoogle Scholar
  • 17 Hutchens Jr LH. The use of a bovine bone mineral in periodontal osseous defects: case reports. Comp Cont Educ Dent 1999; 20: 365-8.
    PubMedGoogle Scholar
  • 18 Institut Fresenius, Taunusstein. Bestimmung von Stickstoff und Kohlenstoff in einem Knochenmaterial. 21.09.2000, Auftrags-Nr.: 100/18622-00.
    PubMedGoogle Scholar
  • 19 Institut für Technische Chemie Hannover, Zentrum für Angewandte Chemie, Prof. Dr. T. Scheper. Ergebnisbericht zum Proteinnachweis im Testmaterial Bio-OSS® 15.01.2001.
    PubMed
  • 20 Johnson RT, Gibbs Jr CJ. Creutzfeldt-Jakob disease and related transmissible spongiform encephalopathies. New Engl J Med 1998; 339 (27) 1994-2004.
    CrossrefPubMedGoogle Scholar
  • 21 Khan SN, Tomin E, Lane JM. Clinical applications of bone graft substitutes. Orthop Clin North Am 2000; 31 (03) 389-98.
    CrossrefPubMedGoogle Scholar
  • 22 Klein CPAT, Driessen AA, Groot KD. Relationship between the degradation behaviour of calcium phosphate ceramics and their physical-chemical characteristics and ultrastructural geometry. Biomaterials 1984; 05: 157-60.
    CrossrefPubMedGoogle Scholar
  • 23 MacNeill SR, Cobb CM, Rapley JW. et al. A. In vivo comparison of synthetic osseous graft materials. A preliminary study. J Clin Periodontol 1999; 26: 239-45.
    CrossrefPubMedGoogle Scholar
  • 24 Merten HA, Hönig JF, Luhr HG. Die Architektur des keramo-ossären Verbund-Regenerates in Abhängigkeit von der Form der Kompaktierung der HA-Granula. Tierexperimentell-histomorphologische Ergebnisse beim Göttinger Minischwein. Dtsch. Mund Kiefer GesichtsChir 1993; 17: 275-80.
    PubMedGoogle Scholar
  • 25 Pietruska MD. A comparative study on the use of Bio-Oss and enamel matrix derivative (Emdogain) in the treatment of periodontal bone defects. Eur J Oral Sci 2001; 109 (03) 178-81.
    CrossrefPubMedGoogle Scholar
  • 26 Schlegel Ak, Donath K. A resorbable bone substitute?. J Long-Term Effects Med Impl 1998; 08: 201-9.
    PubMedGoogle Scholar
  • 27 Schwartz Z, Weesner T, van Dijk S. et al. Ability of deproteinized cancellous bovine bone to induce new bone formation. J Periodontol 2000; 71: 1258-69.
    CrossrefPubMedGoogle Scholar
  • 28 Shigeyama Y, D´Errico JA, Stone R. et al. Commercially-prepared allograft material has biologic activity in vitro. J Periodontol 1995; 66 (06) 478-87.
    CrossrefPubMedGoogle Scholar
  • 29 Sogal A, Tofe AJ. Risk assessment of bovine spongiform encephalopathy transmission through bone graft material derived from bovine bone used for dental applications. J Periodontol 1999; 70 (09) 1053-63.
    CrossrefPubMedGoogle Scholar
  • 30 Soost F, Reissbauer B, Hermann A. et al. Natürliches korralines Calciumkarbonat als alternativer Ersatz bei knöchernen Defekten des Schädels. Mund Kiefer GesichtsChir 1998; 02: 96-100.
    CrossrefPubMedGoogle Scholar
  • 31 Su-Gwan K, Hak-Kyun K, Sung-Chul L. Combined implantation of particulate dentine, plaster of Paris, and a bone xenograft (Bio-Oss®) for bone regeneration in rats. J Craniomaxillofac Surg 2001; 29 (05) 282-8.
    CrossrefPubMedGoogle Scholar
  • 32 Szabo G, Suba Z, Hrabak K. et al. Autogeneous bone versus beta-tricalcium phosphate graft alone for bilateral sinus elevations (2- and 3-dimensional computed tomographic, histologic, and histomorphometric evaluations): preliminary results. Int J Oral Maxillofac Implants 2001; 16 (05) 681-92.
    PubMedGoogle Scholar
  • 33 Szucs A, Suba Z, Martonffy K. et al. The value of beta-tricalcium-phosphate (Cerasorb) in pre-prosthetic surgery. Fogorv Sz 2000; 93 (02) 45-52.
    PubMedGoogle Scholar
  • 34 Tawil G, Mawla M. Sinus floor elevation using a bovine bone mineral (Bio-Oss) with or without the concomitant use of a bilayered collagen barrier (Bio-Gide): a clinical report of immediate and delayed implant placement. Int J Oral Maxillofac Implants 2001; 16 (05) 713-21.
    PubMedGoogle Scholar
  • 35 Wenz B, Oesch B, Horst M. Analysis of the risk of transmitting bovine spongiform encephalopathy through bone grafts derived from bovine bone. Biomaterials 2001; 22 (12) 1599-1606.
    CrossrefPubMedGoogle Scholar
  • 36 Wetzel AC, Stich H, Caffesse RG. Bone apposition onto oral implant in the sinus area filled with differented grafting materials. A histological study in beagle dogs. Clin Oral Impl Res 1995; 06: 155-63.
    CrossrefPubMedGoogle Scholar
  • 37 Wiltfang J, Merten HA. Glaskeramik als Knochenersatzstoff im Vergleich zur biologisch abbaufähigen Kunststofftamponade aus Hydroxysäure. Z Zahnärztl Implantol 1998; 14: 107-11.
    PubMedGoogle Scholar
  • 38 Winking R. Knochenbildung durch equines Biomaterial. Implantol J 2001; 05: 83-5.
    PubMedGoogle Scholar
  • 39 Zerbo IR, Bronckers AL, de Lange GL. et al. Histology of human alveolar bone regeneration with a porous tricalcium phosphate. A report of two cases. Clin Oral Implants Res 2001; 12 (04) 379-84.
    CrossrefPubMedGoogle Scholar
  • 40 Zitzmann NU, Schaper P, Marinello CP. et al. Alveolar ridge augmentation with Bio-Oss: a histologic study in humans. Int J Periodontics Restorative Dent 2001; 21 (03) 288-95.
    PubMedGoogle Scholar