Die neuropathische Drüsenmagendilatation der Psittaziden und das aviäre Bornavirus als potenzielle Ursache

Zusammenfassung

Gegenstand: Die neuropathische Drüsenmagendilatation der Psittaziden (PDD) ist eine bedeutende Erkrankung von Papageien, die stets letal endet. Sie tritt bei zahlreichen Papageienspezies auf und bedroht ganze Zuchtbestände, kommt bei anderen Vogelfamilien dagegen sehr selten vor. Die Ursache dieser Erkrankung war bislang unklar, obwohl schon lange eine Virusätiologie vermutet wurde. Kürzlich gelang der Nachweis eines neuen Virus (aviäres Bornavirus [ABV]) aus an PDD erkrankten Papageien, das seitdem als wahrscheinlichste Ursache gilt. Obwohl auch klinisch gesunde Papageien eine ABV-Infektion aufweisen können, zeigen verschiedene Studien einen Zusammenhang zwischen der Virusinfektion und der klinischen Erkrankung der PDD auf. Neben dem direkten Virusnachweis eignen sich auch serologische Methoden zum Infektionsnachweis. Schlussfolgerungen: Das aviäre Bornavirus ist zurzeit der wahrscheinlichste Kandidat als Erreger der PDD. Zuchtbestände und Neuzugänge sollten daher molekularbiologisch und serologisch auf eine Infektion mit ABV überprüft werden. Der diagnostische Wert des ABV-Infektionsnachweises zur Absicherung der klinischen Diagnose PDD muss in weiteren Studien genauer abgeklärt werden.

Summary

Objective: Proventricular Dilatation Disease (PDD) is a very important letal disease in parrots. It affects several psittacine species and is a high risk factor for the health of breeding collections, but is rarely observed in other avian families. To date, the etiology of the disease remained unclear, though a virus infection was always assumed. Recently, a novel virus (Avian Bornavirus [ABV]) was discovered in parrots suffering from PDD so that ABV is now considered as the most likely cause. Despite the fact that clinically healthy birds may be infected with ABV, several studies demonstrate a correlation between ABV-infection and clinically present PDD. Apart from direct virus detection, serological methods allow the demonstration of an infection. Conclusions: Currently, Avian Bornavirus is the leading candidate as the aetiologic agent of PDD. Breeding collections and birds planned to be introduced into collections should therefore be investigated by molecular biological and serological methods for the presence of an ABV-infection. The diagnostic value of the demonstration of an ABV-infection for the diagnosis of a clinically present PDD has to be investigated further.

Schlüsselwörter

Papageien - ZNS - Enzephalitis - Ganglioneuritis - Serologie - Real-time-RTPCR

Key words

Parrots - CNS - ganglioneuritis - encephalitis - serology - real time RT-PCR

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