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Tierarztl Prax Ausg K Kleintiere Heimtiere 2012; 40(01): 64-69
DOI: 10.1055/s-0038-1623622
Kasuistik
Schattauer GmbH

Zwei Fallberichte einer disseminierten Toxoplasmose

Two cases of disseminated toxoplasmosis
B. Stief
1   Landesuntersuchungsanstalt Sachsen, Standort Dresden, Dresden
,
C. Kiesow
2   Landesamt für Verbraucherschutz Sachsen-Anhalt, Stendal
,
C. Ellenberger
3   Institut für Veterinärpathologie, Universität Leipzig
› Author Affiliations
Further Information

Publication History

Eingegangen: 10 December 2010

Akzeptiert nach Revision: 24 January 2011

Publication Date:
05 January 2018 (online)

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Zusammenfassung

Es werden die Fälle einer disseminierten letalen Toxoplasmose bei einer Farbmaus (Mus musculus) und einem Roten Panda (Ailurus fulgens) vorgestellt. Es handelte sich um eine als Haustier gehaltene Farbmaus und einen Roten Panda aus einem sächsischen zoologischen Garten. Die pathologische Untersuchung ergab bei beiden Tieren eine systemische Toxoplasmeninfektion. Eine hochgradige nekrotisierende Hepatitis stellte in beiden Fällen den histologischen Hauptbefund dar. Parasitenzysten fanden sich massenhaft in der Leber, in mäßiger Zahl im Gehirn und in geringer Zahl in anderen Organen. Mittels PAS-Reaktion waren diese Zysten bei der Farbmaus kaum darstellbar, beim Roten Panda dagegen sehr deutlich. PCR bzw. Immunhistologie bestätigten die Diagnose.

Summary

Two cases of disseminated fatal toxoplasmosis of a pet mouse and a red panda are described.The pet mouse had a private owner; the red panda lived in a zoological garden in Saxony. At necropsy, both animals suffered from a systemic toxoplasmosis.A severe necrotizing hepatitis was the main histological feature in both animals. Parasitic cysts could be abundantly found in the liver, moderately in the brain and in a low number in other organs. With the PAS-reaction, cysts showed a weak staining in the mouse and a strong staining in the red panda. Diagnosis was confirmed by PCR and immunohistochemistry.

Schlüsselwörter

Roter Panda - Farbmaus - Toxoplasma gondii - systemische Endoparasitose

Key words

Red panda - pet mouse - Toxoplasma gondii - systemic endoparasitosis
 

  • Literatur

  • 1 Appel MJ, Yates RA, Foley GL, Bernstein JJ, Santinelli S, Spelman LH, Miller LD, Arp LH, Anderson M, Barr M. Canine distemper epizootic in lions, tigers, and leopards in North America. J Vet Diagn Invest 1994; 06 (03) 277-288.
    CrossrefPubMedSearch in Google Scholar
  • 2 Centers for Disease Control: Toxoplasmosis. Atlanta, GA 30333, USA, 2008
    PubMedSearch in Google Scholar
  • 3 Davidson MG, Rottman JB, English RV, Lappin MR, Tompkins MB. Feline immunodeficiency virus predisposes cats to acute generalized toxoplasmosis. Am J Pathol 1993; 143 (05) 1486-1497.
    PubMedSearch in Google Scholar
  • 4 Dreesen DW. Toxoplasma gondii infections in wildlife. J Am Vet Med Assoc 1990; 196 (02) 274-276.
    PubMedSearch in Google Scholar
  • 5 Dubey JP, Quinn WJ, Weinandy D. Fatal neonatal toxoplasmosis in a bobcat (Lynx rufus). J Wildl Dis 1987; 23 (02) 324-327.
    CrossrefPubMedSearch in Google Scholar
  • 6 Dubey JP, Hamir AN, Hanlon CA, Rupprecht CE. Prevalence of Toxoplasma gondii infection in raccoons. J Am Vet Med Assoc 1992; 200 (04) 534-536.
    PubMedSearch in Google Scholar
  • 7 Dubey JP, Speer CA, Shen SK, Kwok OC, Blixt JA. Oocyst-induced murine toxoplasmosis: life cycle, pathogenicity, and stage conversion in mice fed Toxoplasma gondii oocysts. J Parasitol 1997; 83 (05) 870-882.
    CrossrefPubMedSearch in Google Scholar
  • 8 Dubey JP, Lindsay DS, Speer CA. Structures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts. Clin Microbiol Rev 1998; 11 (02) 267-299.
    CrossrefPubMedSearch in Google Scholar
  • 9 Dubey JP, Rajendran C, Ferreira LR, Kwok OC, Sinnett D, Majumdar D, Su C. A new atypical highly mouse virulent Toxoplasma gondii genotype isolated from a wild black bear in Alaska. J Parasitol 2010; 96 (04) 713-716.
    CrossrefPubMedSearch in Google Scholar
  • 10 Elwell MR, Frenkel JK. Acute toxoplasmosis in hamsters and mice: measurement of pathogenicity by fever and weight loss. Am J Vet Res 1984; 45 (12) 2663-2667.
    PubMedSearch in Google Scholar
  • 11 Eckert J, Friedhoff KT, Zahner H, Deplazes P. In: Lehrbuch der Parasitologie für die Tiermedizin. Eckert J. Hrsg. Stuttgart: Enke; 2008: 30-141.
    Search in Google Scholar
  • 12 Gardiner CH, Fayer R, Dubey JP. An Atlas of Protozoan Parasites in Animal Tissues. Armed Forces Institute of Pathology. Washington DC, USA: 1988
    Search in Google Scholar
  • 13 Herrmann DC, Pantchev N, Vrhovec MG, Barutzki D, Wilking H, Fröhlich A, Lüder CG, Conraths FJ, Schares G. Atypical Toxoplasma gondii genotypes identified in oocysts shed by cats in Germany. Int J Parasitol 2010; 40 (03) 285-292.
    CrossrefPubMedSearch in Google Scholar
  • 14 Innes EA. Toxoplasmosis: comparative species susceptibility and host immune response. Comp Immunol Microbiol Dis 1997; 20 (02) 131-138.
    PubMedSearch in Google Scholar
  • 15 Juan-Sallés C, Prats N, López S, Domingo M, Marco AJ, Morán JF. Epizootic disseminated toxoplasmosis in captive slender-tailed meerkats (Suricata suricatta). Vet Pathol 1997; 34 (01) 1-7.
    CrossrefPubMedSearch in Google Scholar
  • 16 Lòpez A. In: Pathologie der Haustiere. McGavin MD, Zachary JF. Hrsg. München: Urban und Fischer; 2009: 433-570.
    Search in Google Scholar
  • 17 Marshall PA, Hughes JM, Williams RH, Smith JE, Murphy RG, Hide G. Detection of high levels of congenital transmission of Toxoplasma gondii in natural urban populations of Mus domesticus. Parasitology 2004; 128: 39-42.
    CrossrefPubMedSearch in Google Scholar
  • 18 Reed WM, Turek JJ. Concurrent distemper and disseminated toxoplasmosis in a red fox. J Am Vet Med Assoc 1985; 187 (11) 1264-1265.
    PubMedSearch in Google Scholar
  • 19 RKI: Epidemiologisches Bulletin Nr. 40, April 2007
    PubMed
  • 20 Shen DF, Matteson DM, Tuaillon N, Suedekum BK, Buggage RR, Chan CC. Involvement of apoptosis and interferon-gamma in murine toxoplasmosis. Invest Ophthalmol Vis Sci 2001; 42 (09) 2031-2036.
    PubMedSearch in Google Scholar
  • 21 Sikarskie JG, Lowrie CT, Kennedy FA, Brady GL. Canine distemper in a vaccinated red panda (Ailurus fulgens fulgens). Proc Am Assoc Zoo Vet 1991; 292-293.
    PubMedSearch in Google Scholar
  • 22 Zachary JF. In: Pathologie der Haustiere. McGavin MD, Zachary JF. Hrsg. München: Urban und Fischer; 2009: 765-874.
    Search in Google Scholar