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Nuklearmedizin 1984; 23(02): 69-72
DOI: 10.1055/s-0038-1624172
Originalarbeiten - Original Articles
Schattauer GmbH

Gastrointestinal Scintigraphy Using 99mTc- or 111In-Labelled Polymer Beads

Gastrointestinale Szintigraphie mit 99mTc- oder 111In-markierten Polymerperlen
J. H. Jordaan
*   From the NUCOR Institute for Life Sciences, Medical Faculty, University of Pretoria, Pretoria, South Africa
,
Irene C. Dormehl
*   From the NUCOR Institute for Life Sciences, Medical Faculty, University of Pretoria, Pretoria, South Africa
,
W. J. Pilloy
**   The Department of Nuclear Medicine, Medical Faculty, University of Pretoria, Pretoria, South Africa
› Author AffiliationsWe wish to thank Prof. J. J. van der Watt, Director Life Sciences, for assistance, and Dr. D. J. Goosen of the H.A. Grové Animal Research Centre for the availability of the animals.
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Publication History

Received: 23 December 1983

Publication Date:
10 January 2018 (online)

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Summary

In order to establish normal and pathological stomach emptying characteristics by external measurement of a radioactive meal using a gamma camera and computer system, it is necessary for the radioactively labelled substance to have the same behaviour in the stomach as the ingested food. Resins containing chelating groups which enable binding to either reduced 99mTcO4 − or 111In+3 were tested for their suitability as tracers mixed into solid food. The preparation of such styrene-divinylbenzene resins containing either triethylenetetramine substituents or the fully carboxymethylated derivatives is discussed, as well as the procedures of labelling with either 99mTcpertechnetate or 111In-chloride. An evaluation of the resins for gastrointestinal scintigraphy was performed on 3 chacma baboons and a male human volunteer with encouraging results.

Zusammenfassung

Zur Feststellung eines normalen oder pathologischen Magenentleerungsbildes mit Anwendung einer radioaktiv markierten Testmahlzeit und mit Datenerfassung über Gammakamera und Rechner ist es wichtig, daß das Radiopharmazeutikum im Magen ähnlich wie die Testmahlzeit reagiert. Geprüft wurde die mögliche Anwendbarkeit verschiedener Harze mit Komplexierungsgruppen zur Bindung von entweder reduziertem 99mTcO4 − oder 111In+3. Die Herstellung solcher Styroldivinylbenzol-Harze entweder mit TriäthylentetraminSubstituenten oder mit voll-karboximethylierten Derivaten, wie auch die Markierung mit 99mTc-Pertechnetat oder 111In-Chlorid wird beschrieben. Bei 3 Chachma-Pavianen und einem normalen Probanden wurde die Verwendbarkeit dieser Harze für die Szintigraphie der Magenentleerung untersucht. Die Ergebnisse waren vielversprechend.

 

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