Left Ventricular Diastolic Performance at Rest in Patients with Angina and Normal Systolic Function - Assessment by Equilibrium Radionuclide Angiography

Summary

The aim of the study was to correlate diastolic function, as evaluated by peak filling rate (PFR) and relative time (TPFR), with the severity of ischemic heart disease, as evaluated by exercise electrocardiography. Accordingly, 83 ischemic patients with effort angina, but normal ejection function at rest and normal left ventricular size, were studied by equilibrium radionuclide angiocardiography within two weeks from the exercise ECG. Diastolic dysfunction, as determined from PFR and, to a lesser extent, from TPFR, is common in patients with ischemic heart disease and normal systolic function. The prevalence and severity of such dysfunction is related more to the severity of the ischemia, as evaluated by the exercise ECG, than to the presence of an old myocardial infarction. Such findings are consistent with the hypothesis that PFR reflects mainly the early diastolic active uncoupling process.

Zusammenfassung

Ziel der Studie ist eine Korrelation zwischen diastolischer Funktion, gemessen als Füllungsspitzenrate (PFR) und der entsprechenden Füllungszeit (TPFR), mit dem Schweregrad der ischämischen Herzerkrankung, der durch ein Belastungs- EKG abgeschätzt wurde. Es wurden 83 Patienten mit ischämischer Herzerkrankung und Belastungsangina, aber normaler Auswurffraktion in Ruhe und normaler Größe des linken Ventrikels durch eine Äquilibrium-Radionuklid- Ventrikulographie innerhalb von zwei Wochen nach dem Belastungs- EKG untersucht. Diastolische Funktionsstörungen, die durch die PFR und in geringerem Grade durch die TPFR bestimmt wurden, sind bei Patienten mit ischämischer Herzerkrankung und normaler systolischer Funktion häufig. Prävalenz und Schweregrad dieser Dysfunktion stehen stärker in Beziehung zum Schweregrad der im Belastungs-EKG gemessenen Ischämie als zu abgelaufenen Herzinfarkten. Diese Ergebnisse stützen die Hypothese, daß die PFR hauptsächlich den Verlauf der aktiven frühdiastolischen Relaxationsbewegung widerspiegelt

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