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Nuklearmedizin 1971; 10(04): 325-337
DOI: 10.1055/s-0038-1624758
Originalarbeiten — Original Articles — Travaux Originaux
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Studies on the Possibility of Increasing the Radioisotope Accumulation in Tumors: Its Relationship with their Metabolic Characteristics

Etude sur la possibilité d’augmenter l’accumulation radioisotopique dans les tumeurs en relation avec leurs caractéristiques métaboliquesUntersuchungen zur Möglichkeit einer Steigerung der Radionuklidspeicherung in Tumoren und deren Beziehungen zu ihren Stoffwechseleigenschaften
Leopoldo J. Anghileri   *
1   University of Colorado Medical Center Veterans Administration Hospital Denver, Colorado, USA
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Publication History

Received: 06 June 1971

Publication Date:
22 January 2018 (online)

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Summary

The effects of various ligands and associated cations on the distribution of complexed chromium have been studied. By using 131I-tagged ligand it has been proved that the ligand follows the chromium distribution pattern, showing high bone and tumor accumulation. The association with calcium ions increases considerably the tumor uptake. This behavior is related to a high calcium turnover observed in tumors. These two phenomena indicate the feasibility of their use for the purpose to increase the radioactivity accumulation in tumors.

On étudie les effets de divers ligands et de cations associés sur la distribution du chrome complexe. En utilisant des ligands marqués avec 131I, il a été prouvé que le ligand suit le schéma de distribution du chrome avec une grande accumulation dans les os et la tumeur. Une association avec des ions calcium fait augmenter considérablement la fixation tumorale. Ce comportement est en relation avec un taux élevé de métabolisme calcique. Ces deux phénomènes indiquent qu’on peut les utiliser pour augmenter l’accumulation radioactive dans les tumeurs.

Es wurden die Wirkungen verschiedener Liganden und mit ihnen verbundener Kationen auf die Verteilung von Chromkomplexen untersucht. Durch Verwendung von 131J-markiertem Ligand konnte nachgewiesen werden, daß das Ligand der Verteilung des Chroms folgt, d. h. eine hohe Knochen- und Tumorspeicherung zeigt. Die Verbindung mit Kalziumionen erhöht die Tumorspeicherung beträchtlich. Dieses Verhalten hängt mit dem hohen Kalziumumsatz zusammen, der in Tumoren beobachtet wird. Diese beiden Ergebnisse weisen auf die Möglichkeit ihrer Anwendung zum Zwecke der Steigerung der Radioaktivitätsanreicherung in Tumoren hin.

* Present address: Klinikum Essen, Tumorforschung der Ruhr-Universität, 43 Essen.


 

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