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Nuklearmedizin 1972; 11(01): 59-69
DOI: 10.1055/s-0038-1624774
Originalarbeiten — Original Articles — Travaux Originaux
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Biological and Chemical Investigations of 131I-Albumin Macroaggregates used for Lung Scintigraphy

Etudes biologiques et biochimiques des macroagrégats de l’albumine marqués avec le iode 131 employés dans la scintigraphic des poumonsBiologische und chemische Untersuchungen von 131J-Albumin-Makroaggregaten zur Lungenszintigraphie
I. Licińska   *
1   Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotopes Production and Distribution Centre, Swierk near Warsaw
,
B. Lucka   **
1   Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotopes Production and Distribution Centre, Swierk near Warsaw
,
B. Pszona   *
1   Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotopes Production and Distribution Centre, Swierk near Warsaw
,
B. Sadowska   **
1   Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotopes Production and Distribution Centre, Swierk near Warsaw
,
M. Wagner   **
1   Institute of Drugs, Laboratory of Radioisotopic Drugs and Institute of Nuclear Research, The Radioisotopes Production and Distribution Centre, Swierk near Warsaw
› Author Affiliations
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Publication History

Received:07 December 1971

Publication Date:
24 January 2018 (online)

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Summary

The parameters required to establish the usefulness of 131I-albumin macroaggregates for lung scintigraphy have been determined. The effects of successive washings, storage time, additional sterilization and of the quality of initial human serum albumin on radiochemical purity and biological behaviour of the product have been investigated.

On a établi des paramètres déterminant l’utilité des macroagrégats de l’albumine marqués par le iode 131 en scintigraphic pulmonaire. L’influence des lavages successifs, le temps de conservation, la stérilisation additionnelle et la qualité initiale du sérum albumine humain sur la pureté radiochimique et les tests biologiques de ce produit ont été étudiés.

Es wurden jene Kriterien festgelegt, die notwendig sind, um die Brauchbarkeit von 131J-Albuminmakroaggregaten zur Lungenszintigraphie zu bestimmen. Die Einflüsse zusätzlicher Waschungen, Lagerungszeit, zusätzlicher Sterilisation und der Qualität des Human-Serumalbumins als Ausgangsmaterial auf die radiochemische Reinheit und auf das biologische Verhalten des Präparates wurden untersucht.

* Institute of Drugs, Laboratory of Radioisotopic Drugs, Swierk near Warsaw.


** Institute of Nuclear Research, The Radioisotopes Production and Distribution Centre, Swierk near Warsaw.


 

  • References

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