Observations on the Therapeutic Merit of Thyroid Radioablation for Treatment of Malignant Exophthalmos

E. R. Weiss; W. H. Blahd; M. A. Winston; G. T. Krishnamurthy

doi:10.1055/s-0038-1624787

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 1972; 11(03): 226-233
DOI: 10.1055/s-0038-1624787

Originalarbeiten — Original Articles — Travaux Originaux

Schattauer GmbH

Observations on the Therapeutic Merit of Thyroid Radioablation for Treatment of Malignant Exophthalmos

Observation sur la valeur thérapeutique de l’élimination radiologique de la thyroide dans le traitement de l’exophthalmie maligneBeobachtungen über den therapeutischen Wert einer Strahlenausschaltung der Schilddrüse in der Behandlung des malignen Exophthalmus

E. R. Weiss

¹From the Nuclear Medicine Service, Veterans Administration Hospital (Wadsworth, Los Angeles) and the Departments of Medicine, UCLA School of Medicine, and USC School of Medicine, Los Angeles

,

W. H. Blahd

¹From the Nuclear Medicine Service, Veterans Administration Hospital (Wadsworth, Los Angeles) and the Departments of Medicine, UCLA School of Medicine, and USC School of Medicine, Los Angeles

,

M. A. Winston

¹From the Nuclear Medicine Service, Veterans Administration Hospital (Wadsworth, Los Angeles) and the Departments of Medicine, UCLA School of Medicine, and USC School of Medicine, Los Angeles

,

G. T. Krishnamurthy

› Author Affiliations

Abstract

7 malades atteints par une exophthalmie sévère ont été traités par des doses elevées de ¹³¹I pour les symptômes oculaires. Dans 6 malades on a obtenue une amélioration. Dans 1 malade les conditions restaient stables malgré la persistance de function de la Atyroide demontrée par la scintigraphic. Les résultats obtenues semblent de montrer que l’élimination radiologique pour traitement de l’exophthalmine maligne n’offre pas des avantages sur les formes de thérapie actuellement en usage.

Summary

Seven patients with severe exophthalmos received ablative doses of ¹³¹I in an attempt to ameliorate their eye disease. Six patients improved and the seventh patient remained stable despite the continued presence of functioning thyroid tissue on follow-up scintigrams. The results of this study would appear to indicate that radioablation for the treatment of malignant exophthalmos offers no advantages over present modes of therapy.

Sieben Patienten mit schwerem Exophthalmus erhielten hohe Dosen von ¹³¹J, um ihre Augenerkrankung zu bessern. Bei sechs Patienten trat eine Besserung ein und der siebente Patient blieb unverändert, obwohl der Fortbestand von funktionierendem Schilddrüsengewebe szintigraphisch nachgewiesen werden konnte. Die Ergebnisse diesere Untersuchungen scheinen zu zeigen, daß die Strahlenausschaltung in der Behandlung des malignen Exophthalmus keine Vorteile gegenüber den derzeitigen Therapieformen bietet.

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References

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