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Nuklearmedizin 1972; 11(03): 281-290
DOI: 10.1055/s-0038-1624792
Originalarbeiten — Original Articles — Travaux Originaux
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Peripheral Metabolism of Thyroxine and Triiodothyronine in Endemic Goitre

Le métabolisme périphérique de la thyroxine et de la triiodothyronine dans les goitres endémiquesPeripherer Stoffwechsel des Thyroxins und des Trijodthyronins bei endemischem Kropf
Calliopi C. Alevizaki
1   From the Department of Endocrinology and Radioisotopes Laboratory, Evangelismos Hospital, Athens
,
Spyros C. Gonticas
1   From the Department of Endocrinology and Radioisotopes Laboratory, Evangelismos Hospital, Athens
,
Denis G. Ikkos
1   From the Department of Endocrinology and Radioisotopes Laboratory, Evangelismos Hospital, Athens
› Author Affiliations
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Publication History

Received:13 March 1972

Publication Date:
15 January 2018 (online)

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Le métabolisme périphérique de la triiodothyronine (T3) et de la thyroxine (T4) a été déterminé simultanément en Grèce chez des personnes affectées d’un goitre non toxique. La comparaison avec des résultats d’une groupe de contrôle montre que chez les goitreux, le métabolisme T4 était normal tandis que le métabolisme T3 était accéléré surtout par un agrandissement de l’espace de distribution du T3. On suppose que le mécanisme de compensation pour les réserves de l’iode diminuées dans le goitre endémique consiste en une augmentation de la production et de l’utilisation du T3.

Summary

The peripheral metabolism of triiodothyronine (T3) and thyroxine (T4) were measured simultaneously in subjects with non-toxic goitre in Greece. Comparison to the results obtained in a control group demonstrated that goitrous subjects showed a normal peripheral T4 metabolism, while their T3 metabolism was enhanced, principally because of an increase of T3 space.

It is suggested that the main compensatory mechanism for decreased iodine reserves in endemic goitre is an increase in T3 production and utilization.

Der periphere Stoffwechsel des Trijodthyronins (T3) und des Thyroxins (T4) wurde in Griechenland bei Personen mit nicht-toxischem Kropf gleichzeitig bestimmt. Der Vergleich mit den Ergebnissen bei einer Kontrollgruppe zeigte, daß bei Kropfpatienten der T4-Stoffwechsel normal war, während der T3-Stoffwechsel beschleunigt war, vor allem durch eine Vergrößerung des T3-Verteilungsraumes.

Es wird angenommen, daß der hauptsächliche Kompensationsmechanismus für die herabgesetzten Jodreserven bei endemischem Kropf in einer Erhöhung der T3-Produktion und -Verwendung besteht.

 

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