Evaluation of Carbon-11 Labelled Phenylglycine and Phenylalanine for Pancreas Scintigraphy

Summary

Carbon-11 (t_½ = 20.4 min, β⁺) labelled DL-α-phenylalanine and DL-α-phenylglycine were administered intravenously to rats and the distribution of the radioactive amino acids over pancreas, liver, spleen, kidneys and blood was measured after several time intervals. From these results the ratios of the concentration in pancreas and liver were calculated and compared with the corresponding ratios from the literature for some ¹⁸F-labelled aromatic amino acids and L-selenomethionine-⁷⁵Se. On the basis of this study it appears that DL-α-phenylglycine-l-¹¹C, in spite of a small percentage of the administered dose reaching the pancreas, and DL-α-phenylalanine-l-¹¹C are better suited to pancreas scintigraphy than L-selenomethionine-⁷⁵Se.

^* This paper represents a portion of the doctoral dissertation of W. Vaalburg.

• References

• 1 Miale A, Rodriguez-Antunez A, Gill WM. Pancreas Scanning after ten years. Seminars in Nuclear Medicine II 1972: 201
• 2 Blau M, Manske RF. The pancreas specificity of ⁷⁵Se-selenomethionine. J. Nucl. Med 1961; 2: 102
• 3 Busch H, Davis JR, Honig GR, erson DC, Nair PV, Nijhan WL. The uptake of a Variety of Amino acids into nuclear proteins of tumors and other tissues. Cancer Res 1959; 19: 1030
• 4 Hoyte RM, San San Lin Christman DR, Atkins HL, Hauser W, Wolf AP. Organic radiopharmaceuticals labeled with short-lived nuclides. III. ¹⁸F-labeled Phenylalanines J. Nucl. Med 1971; 12: 280
• 5 Goulding RW, Palmer AJ. The preparation of Fluorine-18 labelled p-fluorophenylalanine for clinical use. Int. J. Appl. Radiat. Isotopes 1972; 23: 133
• 6 Taylor DM, Cottrall MF. Evaluation of amino-acids labelled with ¹⁸F for pancreas scanning. Proc. IAEA-WHO Symp. Copenhagen, „Radiopharmaceuticals and labelled Compounds“ 1973; Vol. I: 433
• 7 Atkins HL, Christman DR, Fowler JS, Hauser W, Hoyte RM, Klopper JF, Lin SS, Wolf AP. Organic radiopharmaceuticals labeled with isotopes of short half-life. V. ¹⁸F-labeled 5- and 6-fluorotryptophan. J. Nucl. Med 1972; 13: 713
• 8 Varma VM, Beierwaltes WH, Lieberman LM, Counsell RE. Pancreatic concentration of ¹²⁵I-labeled phenylalanine in mice. J. Nucl. Med 1969; 10: 219
• 9 Silvester DJ. Accelerator production of medically useful radionuclides. Proc. IAEA-WHO Symp. Copenhagen, „Radiopharmaceuticals and labelled Compounds“ Vol. I p. 1973; 197
• 10 Lathrop KA, Harper PV, Rich BH, Dinwoodie R, Krizek H, Lembares N. Rapid incorporation of short-lived cyclotron-produced radionuclides into radiopharmaceuticals. Proc. IAEA-WHO Symp. Copenhagen, „Radiopharmaceuticals and labelled Compounds“ Vol. I p. 1973; 471
• 11 Cohen MB, Spolter L, Mac Donald N, Masouka DT, Laws S, Neely HH, Takahashi J. Production of ¹³N-labelled amino-acids by enzymatic synthesis. Proc. IAEA-WHO Symp. Copenhagen, „Radiopharmaceuticals and labelled Compounds“ Vol. I p. 1973; 483
• 12 Gelbard AS, Clarke LP, Mac Donald JM, Laughlin JS. Enzymatic synthesis and evaluation of ¹³N-labeled amino acids as myocardial scanning agents (abstract) J. Nucl. Med 1974; 15: 492
• 13 Spolter L, Cohen MB, Mac Donald Chia Ching Chang N, Takahashi J, Neely H, Huth G, Meyers S, Bobinet D. Synthesis and evaluation of ¹³N-L-alanine for pancreatic imaging (abstract). J. Nucl. Med 1974; 15: 535
• 14 Hara T, Taylor C, Lembares N, Lathrop KA, Harper PV. L-Aspartic Acid-4-¹¹C as a tumor scanning agent (abstract). J. Nucl. Med 1971; 12: 361
• 15 Weimer K. Development of fast syntheses of amino acids and fatty alcohols labelled with carbon-11. Diss. Univ. Darmstadt; Germany: 1973
• 16 Vaalburg W, Beerling-vander Molen HD, Reiffers S, Rijskamp A, Woldring MG, Wynberg H. Preparation of carbon-11 labelled phenylalanine and phenylglycine by a new amino acid synthesis. Submitted for publication
• 17 Finn RD, Wolf AP. Cyclotron preparation of ¹¹C-Carbon dioxide from a nitrogen gas target (abstract). J. Nucl. Med 1972; 13: 429
• 18 Scow RO. „Total“ Pancreatectomy in the rat: operation, effects, and postoperative care. Endocrinology 1957; 60: 359
• 19 Versluis A. Unpublished results