Partition Coefficient of 133Xe between Blood and Eye Tissues

H. Kowalski; A. Marczak; A. Moszczyńska-Kowalska

doi:10.1055/s-0038-1624911

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 1975; 14(04): 301-309
DOI: 10.1055/s-0038-1624911

Originalarbeiten — Original Articles

Schattauer GmbH

Partition Coefficient of ¹³³Xe between Blood and Eye Tissues

Verteilungskoeffizient von ¹³³Xe zwischen Blut und Augengewebe

H. Kowalski

¹Dept. of Biophysics, Institute of Physiological Sciences, Medical Academy, Warsaw (Chief: Prof. Dr. S. Marciniak), Ophthalmic Clinic, Medical Academy Warsaw (Chief: Prof. Dr. Z. Falkowska)

,

A. Marczak

¹Dept. of Biophysics, Institute of Physiological Sciences, Medical Academy, Warsaw (Chief: Prof. Dr. S. Marciniak), Ophthalmic Clinic, Medical Academy Warsaw (Chief: Prof. Dr. Z. Falkowska)

,

A. Moszczyńska-Kowalska

¹Dept. of Biophysics, Institute of Physiological Sciences, Medical Academy, Warsaw (Chief: Prof. Dr. S. Marciniak), Ophthalmic Clinic, Medical Academy Warsaw (Chief: Prof. Dr. Z. Falkowska)

› Author Affiliations

Abstract

Summary

The relative solubility coefficient of ¹³³Xe and the tissue-blood partition coefficient for the aqueous humour vitreous body, conjunctiva and external eye muscles of the rabbit were determined in vitro at 37° C and at various haematocrit values. The partition coefficient for haematocrit 40 was: for the aqueous humour 0,49 ml/ml, for the vitreous body 0,50 ml/ml, for the conjunctiva 0,81 ml/g and for the external eye muscles 0,77 ml/g. It was found that the solubility of ¹³³Xe in rabbit erythrocytes is about 50 per cent higher than that in human red cells. The consequences of this fact for the precision of blood flow measurements by the method of tissue clearance are discussed.

In Untersuchungen in vitro wurde der relative Löslichkeitskoeffizient ¹³³Xe und Verteilungsfaktor Zellgewebe-Blut für Kammerwasser, Glaskörper und äußere Muskeln des Kaninchenauges bei 37° C bestimmt und für verschiedene Werte Hämatokrit. Verteilungsfaktor für Hämatokrit 40 beträgt für Kammerwasser 0,49 ml/ml., Bindehaut 0,81 ml/g, Glaskörper 0,50 ml/ml und für äußere Muskeln 0,77 ml/g. Es wurde festgestellt, daß die Löslichkeit von ¹³³Xe in Kaninchenerytrozyten beinahe um 50% größer ist als in Menschenblutkörperchen. Es wurde auch die Genauigkeit der Messungen der Blutbewegung mittels der Gewebe-Clearance-Methode diskutiert.

Full Text

References

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