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Nuklearmedizin 1975; 14(04): 365-373
DOI: 10.1055/s-0038-1624918
Originalarbeiten — Original Articles
Schattauer GmbH

Bifunctional Chelates for Radio-Pharmaceutical Labeling[*]

Bifunktionelle Chelate zur radiopharmakologischen Markierung
D. A. Goodwin
1   Stanford University School of Medicine and Veterans Administration Hospital, Palo Alto, California 94304
,
C. F. Meares
2   Chemistry Department, Stanford University, Stanford, California 94305
,
C. I. Diamanti
1   Stanford University School of Medicine and Veterans Administration Hospital, Palo Alto, California 94304
,
M. W. Sundberg
3   Chemistry Department, Stanford University, Stanford, California 94305
› Author Affiliations
Further Information

Publication History

Received:00 September 1974

Publication Date:
12 January 2018 (online)

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Summary

The use of the first of a new class of chelating agents for the binding of metal ions to macromolecules as a novel approach to radiopharmaceutical labeling is described. Advantages are mild reaction conditions, large variety of accessible radionuclides and reactive groups, and separation of synthetic organic chemistry from radiochemistry. Human serum albumin and bovine fibrinogen labeled with mIndium using this technique were relatively stable in vitro and in vivo, showed little alteration in function, and have potential as tumor localizing agents in humans.

Die Verwendung eines ersten aus einer neuen Klasse von Chelatbildnern zur Bindung von Metallionen an Makromoleküle als neuer Weg einer radiopharma-kologischen Markierung wird beschrieben. Vorteile liegen in milden Reaktions-bedingungen, einer großen Breite zugänglicher Radionuklide und reaktiver Gruppen sowie Trennung der synthetischen organischen Chemie von der Radiochemie. Menschliches Serumalbumin und Rinderfibrinogen, die mittels dieser Technik mit 111In markiert wurden, zeigten sich in vitro und in vivo relativ stabil, zeigten nur geringe funktionelle Änderung und werden möglicherweise zur Tumor-lokalisation Bedeutung erlangen.

* Die Arbeit wurde auf dem Weltkongreß für Nuklearmedizin in Tokio 1974 mit dem von Hevesy-Preis ausgezeichnet.


 

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