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Nuklearmedizin 1976; 15(03): 131-134
DOI: 10.1055/s-0038-1624946
Originalarbeiten — Original Articles
Schattauer GmbH

Significance of Renal Visualization during Bone Scanning in Paget’s Disease

Die Bedeutuug der Nierendarstellung in Knochenszintigrammen bei Patienten mit M. Paget
P. F. Winter
1   From the Division of Nuclear Medicine, Columbia University, College of Physicians and Surgeons, New York
,
Ph. M. Johnson
1   From the Division of Nuclear Medicine, Columbia University, College of Physicians and Surgeons, New York
› Author Affiliations
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Publication History

Received:21 January 1976

Publication Date:
11 January 2018 (online)

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Summary

In 17 of 26 patients with extensive, symptomatic Paget’s disease poor renal visualization was noted on bone scanning with 99mTc-diphosphonate. Renal function was normal in all patients. The intensity of the renal image proved to be inversely related to the extent and metabolic activity of the Pagetic process. This finding supports the hypothesis that in Paget’s disease the balance between skeletal and renal extraction of circulating tracer may be displaced in favor of the former.

Siebzehn von 26 Patienten mit fortgeschrittenem, symptomatischem Morbus Paget hatten eine verminderte Nierenradioaktivität im Knochenszintigramm mit 99mTc-Diphosphonat. Die Nierenfunktion aller Patienten war normal. Die Intensität der Nierendarstellung verhielt sich umgekehrt zum Ausmaß und zur metabolischen Aktivität des Morbus Paget. Diese Beobachtung unterstützt die Hypothese, daß bei Morbus Paget das Verhältnis zwischen Knochen- und Nierenextraktion des zirkulierenden Radiopharmakons zugunsten der Knochenaufnahme verschoben ist.

The Paget’s disease treatment program at this institution has been supported by the NIH grants AM-09579 and RR-00645.


 

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