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Nuklearmedizin 1976; 15(04): 168-172
DOI: 10.1055/s-0038-1624955
Originalarbeiten — Original Articles
Schattauer GmbH

Determination of Placental Blood Flow by External Monitoring of 113mIn

Bestimmung des plazentaren Blutstroms durch externe Messung von 113mIn
H. Olkkonen
1   From the University Central Hospital, Kuopio (Finland)
,
S. Suonio
1   From the University Central Hospital, Kuopio (Finland)
,
P. Haring
1   From the University Central Hospital, Kuopio (Finland)
› Author Affiliations
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Publication History

Received:12 March 1976

Publication Date:
11 January 2018 (online)

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Summary

A simple and noninvasive technique was developed to evaluate the blood perfusion rate within human placenta. The method is based on monitoring the accumulation of the isotope 113mIn in the placental intervillous space using a single detector as a measuring device. The result was expressed as an accumulation index calculated from the tracer appearance curve. The In accumulation index was significantly lower in preeclamptic patients than in the controls, but with a marked overlapping. The In index was significantly correlated with the simultaneously recorded maternal minute volume, 24-hour estrogen excretion and birthweight. No correlation was found with the placental weight or Laakso’s perfusion index. Uterine contractions induced a significant decrease in the In index. The authors conclude that the In accumulation index can be used as an objective measure of the placental blood flow.

Es wurde eine einfache nicht invasive Technik entwickelt, um die Blutperfusionsrate in der menschlichen Plazenta zu bestimmen. Die Methode basiert auf der Feststellung der Akkumulation des radioaktiven Isotops 113m-I n in dem plazentaren intervillösen Raum durch Gebrauch eines einfachen Detektors als Meßinstrument. Das Resultat wird dargestellt als ein Akkumulations-Index, welcher aus der Tracer-Erscheinungskurve berechnet wird. Der In-Akkumulationsindex lag gegenüber den Kontrollen bei präeklamptischen Patienten signifikant tiefer.

Der Index hatte eine signifikante Korrelation zu dem simultan aufgezeichneten mütterlichen Minutenvolumen, bzw. zur 24 Std. Östrogen-Exkretion und zum Geburtsgewicht. Keine Korrelation wurde gegenüber dem Plazentagewicht bzw. dem „Laakso’s perfusion index“ gefunden. Uteruskontraktionen induzierten einen signifikanten Abfall des In-Index.

Die Autoren schließen, daß der In-Akkumulations-Index als ein objektives Maß des plazentaren Blutflusses verwendet werden kann.

 

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