Download PDF
Nuklearmedizin 1976; 15(06): 282-286
DOI: 10.1055/s-0038-1624977
Originalarbeiten — Original Articles
Schattauer GmbH

99mTechnetium-Unithiol Complex, a New Pharmaceutical for Kidney Scintigraphy

M. Ogiński
1   From the Division of Nuclear Medicine, Medical Research Centre, Medical School of Łódź (Head: Prof, dr hab. Julian Liniecki) Lodz
,
M. Rembelska
1   From the Division of Nuclear Medicine, Medical Research Centre, Medical School of Łódź (Head: Prof, dr hab. Julian Liniecki) Lodz
› Author Affiliations
Further Information

Publication History

Received:10 October 1976

Publication Date:
10 January 2018 (online)

Also available at
  PDF Download  Permissions and Reprints

Summary

The investigations were carried out with a newly syn-thesised, original 99mTc-Unithiol complex (Unithiol-2,3-dimercaptopropansulphonate). It accumulates in the kidneys and enables their scintigraphic examination at 90—180 minutes after the administration. The study was performed on rats, rabbits and dogs. 99mTc-Unithiol complex accumulation in rat kidneys was 34,9%, 44,5% and 67,8% of dose after 1, 2 and 3 h respectively.

Good reability of the scintigraphic picture of the kidneys in rabbits and dogs confirms the accumulative capability of the complex in these organs. It was found by means of ascending paper chromatography that the purity of the 99mTc-Unithiol complex exceeded 90%.

 

  • References

  • 1 Baker R. J, Bellen J. C, Ronal P. M. Technetium-99m-Pyridoxylidenglutamate: a new hepatobiliary Radiopharmaceutical. I. Experimental aspects. J. Nucl. Med 1975; 16: 720-727.
    PubMedSearch in Google Scholar
  • 2 Blaumonte N. Chlormerodrina use of mercury 197 and 203 labelled for kidneys scanning. Answer to the Atomic Energy Commission O. N. J. Nucl. Med 1968; 9: 206.
    Search in Google Scholar
  • 3 Borisow W. P, Zurawliew W. Z, Iwanow W. A, Sewerin S. Z. Nieottoznaja Pomoszcz pri ostrych pora-zenijach Radioaktiwnymi Wieszczestwami. Atomizdat. (Moskwa). 1968: 140
    Search in Google Scholar
  • 4 Graban W, Jakubowski W. The harmful effects preparations labelled with 203Hg used for clinical diagnosis. Pol. Przeg. Rad. Med. Nukl. XXXIV, 1975; 5: 595-598.
    Search in Google Scholar
  • 5 Halpern S, Tubis M, Endow J, Walsh C, Kunsa J, Zwicker B. 99mTc-penicillamine-acetazolamide complex, a new renal scanning agent. J. Nucl. Med 1972; 13: 45-50.
    PubMedSearch in Google Scholar
  • 6 Hambright P, McRae J, Valk P. E, Bearden A. J, Shipley B. Chemistry of technetium radiopharmaceuticals, I. Exploration of the tissue distribution and oxidation sate consequences of technetium (IV) in Tc-Sn-Gluconate and Tc-Sn-EHDP using carrier 99mTc. J. Nucl. Med 1975; 16: 478-482.
    PubMedSearch in Google Scholar
  • 7 Handmaker H, Young Bradford W, Lowestein J. M. Clinical Experience with 99mTc-DMSA (Dimercapto-succinic acid) a new renal-imaging agent. J. Nucl. Med 1975; 16: 28.
    PubMedSearch in Google Scholar
  • 8 Hecking E, Pfannenstiel P. Nierenszintigraphie mit 99mTc-DTPA-Fe-Komplex. Urologe. 1973: 126-129.
    Search in Google Scholar
  • 9 Konikowski T, Glenn H. J, Haynie T. P, Jahns M. F. An intercomparison of radiopharmaceutical kidney kinetics in the mouse. Int. J. Nucl. Med. Biol 1975; 2: 59-65.
    CrossrefPubMedSearch in Google Scholar
  • 10 Lin T. H, Khentigan A, Winchell H. S. A 99mTC-chelate substitute for organradiomerciurial renal agents. J. Nucl. Med 1974; 15: 34-35.
    PubMedSearch in Google Scholar
  • 11 McRae J, Barry A. C, Valk P. E. Renal scintigraphy using technetium stannous chloride gluconate. Aust. N. Z. J. Med. 1971: 291 published in New Chemicals GmbH. D-6072 Dreieichenhain. W.-Germany: Stannous Glucoheptonate Kit for use in the preparation of Technetium 99mTc for renal scanning, p. 12 (1975)
    Search in Google Scholar
  • 12 Nouel J. P, Renault H, Robert J, Bertrand A, Dubois D, Brunelle Ph. L’Ascorbate ferrous marque — Interet pour la scintigraphic renale. Nouv. Presse méd 1972; 1 (36) 2399.
    PubMedSearch in Google Scholar
  • 13 Ogiński M, Kloczkowski K. Use of unithiol for reducing radioation hazard of renal scintigraphy with chlormerodrin 203Hg. I. Estimation of the urinary excretion of 203Hg. International Urol. Neph 1973; 5: 371-376.
    Search in Google Scholar
  • 14 Starshinova A. E. A study on the antiarrhythmic action of unithiol in an experimental. Medycyna (Moskwa). 1975: 168-170.
    Search in Google Scholar
  • 15 Richard W. A, Subramanian G, McAfee J. G, Blair R. J, Deaver Thomas F. Comparison of 99mTc complexes for renal imaging. J. Nucl. Med 1975; 16: 357-367.
    PubMedSearch in Google Scholar
  • 16 Woźniak L, Ogiński M, Karasek M, Piatek T. Histologische und histochemische Untersuchungen an Rattennieren nach Verabreichung von Chlormerodrin 203Hg und Unithiol. Fortschr. Röntgenstr 1973; 119: 603-609.
    Thieme ConnectSearch in Google Scholar