Download PDF
Schlaf 2017; 06(01): 11-13
DOI: 10.1055/s-0038-1626157
Review
Schattauer GmbH

Demenz & Schlafapnoe

DIRK M. HERMANN
1   Lehrstuhl für vaskuläre Neurologie, Demenz und Altersforschung, Universitätsklinikum Essen, Neurologische Klinik Hufelandstrasse 55, 45122 Essen, Email: dirk.hermann@uk-essen.de
› Author Affiliations
Further Information

Publication History

Publication Date:
12 February 2018 (online)

    Permissions and Reprints

Während Zusammenhänge zwischen Schlafapnoe und zerebrovaskulären Erkrankungen in der klinischen Neurologie inzwischen sorgfältig belegt sind, war der Schlafapnoe-Einfluss auf Entwicklung und Fortschreiten von Demenzerkrankungen lange Zeit schlecht untersucht. In den letzten Jahren wiesen zwei bevölkerungsbasierte Studien eine Häufung der leichten kognitiven Beeinträchtigung oder Demenz bei Schlafapnoe-Patienten nach. Angesichts zahlreicher negativer pharmakologischer Studien ist die Behandlung des Schlafapnoe-Syndroms mit CPAP möglicherweise ein vielversprechender Weg, die Demenzentwicklung günstig zu beeinflussen.

 

  • Literatur

  • 1 Ancoli-Israel S. et al. Cognitive effects of treating obstructive sleep apnea in Alzheimer‘s disease: a randomized controlled study. J Am Geriatr Soc 2008; 56 (11) 2076-2081.
    CrossrefGoogle Scholar
  • 2 Chang WP, Liu ME, Chang WC. et al. Sleep apnea and the risk of dementia: a population-based 5-year follow-up study in Taiwan. PLoS One 2013; 8 (10) e78655.
    Google Scholar
  • 3 Chong MS. et al. Continuous positive airway pressure reduces subjective daytime sleepiness in patients with mild to moderate Alzheimer‘s disease with sleep disordered breathing. J Am Geriatr Soc 2006; 54 (05) 777-781.
    CrossrefGoogle Scholar
  • 4 Cooke JR. et al. Continuous positive airway pressure deepens sleep in patients with Alzheimer‘s disease and obstructive sleep apnea. Sleep Med 2009; 10 (10) 1101-1106.
    CrossrefGoogle Scholar
  • 5 Ding X, Kryscio RJ, Turner J. et al. Self-Reported Sleep Apnea and Dementia Risk: Findings from the Prevention of Alzheimer‘s Disease with Vitamin E and Selenium Trial. J Am Geriatr Soc 2016; 64 (12) 2472-2478.
    CrossrefGoogle Scholar
  • 6 Frohnhofen H, Heuer HC, Kanzia A, Firat A. Influence of type of treatment for sleep apnea on activities of daily living in a sample of elderly patients with severe sleep apnea. J Physiol Pharmacol 2009; 60 (Suppl. 05) 51-55.
    Google Scholar
  • 7 Hermann DM, Bassetti CL. Role of sleep-disordered breathing and sleep-wake disturbances for stroke and stroke recovery. Neurology 2016; 87 (13) 1407-1416.
    CrossrefGoogle Scholar
  • 8 Kadotani H, Kadotani T, Young T. et al. Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults. JAMA 2001; 285 (22) 2888-2890.
    CrossrefGoogle Scholar
  • 9 Kernan WN, Ovbiagele B, Black HR. et al.; American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and Council on Peripheral Vascular Disease. Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2014; 45 (07) 2160-2236.
    CrossrefGoogle Scholar
  • 10 Kim H. et al. Obstructive sleep apnea as a risk factor for cerebral white matter change in a middle-aged and older general population. Sleep 2013; 36 (05) 709-715B.
    CrossrefGoogle Scholar
  • 11 Moraes W, Poyares D. et al. Donepezil improves obstructive sleep apnea in Alzheimer disease: a double-blind, placebo-controlled study. Chest 2008; 133 (03) 677-683.
    CrossrefGoogle Scholar
  • 12 Troussière AC, Charley CM, Salleron J. et al. Treatment of sleep apnoea syndrome decreases cognitive decline in patients with Alzheimer‘s disease. J Neurol Neurosurg Psychiatry 2014; 85 (12) 1405-1408.
    CrossrefGoogle Scholar
  • 13 Yaffe K, Laffan AM. et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA 2011; 306 (06) 613-619.
    CrossrefPubMedGoogle Scholar