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Nervenheilkunde 2007; 26(01/02): 13-21
DOI: 10.1055/s-0038-1626822
Arbeiten zum Schwerpunkt - Theme Articles
Schattauer GmbH

Operative und interventionelle Therapieverfahren beim Cluster-Kopfschmerz

Interventional therapy in cluster headache
A. May
1   Institut für systemische Neurowissenschaften, Universitätsklinikum Hamburg, UKE
,
J. Vesper
2   Abteilung Stereotaktische Neurochirurgie, Universitätsklinikum Freiburg
,
S. Evers
3   Klinik und Poliklinik für Neurologie, Universitätsklinikum Münster
,
G. Nikkhah
2   Abteilung Stereotaktische Neurochirurgie, Universitätsklinikum Freiburg
› Author Affiliations
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Publication History

Publication Date:
19 January 2018 (online)

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Zusammenfassung

Cluster-Kopfschmerz ist manchmal schwer zu therapieren und bei völligem Versagen der medikamentösen Therapien existieren operative Ansätze des Trigeminus. Bekannt ist, dass die Rezidivrate für diese Verfahren hoch ist. Zusätzlich besteht die Gefahr dauernder Funktionseinbußen oder einer anaesthesia dolorosa. In manchen Fällen ist die Leitungsanästhesie des Nervus occipitalis major erfolgreich und sollte daher auch bei Patienten mit chronischem ClusterKopfschmerz vor einer invasiven Therapie versucht werden. Als Prinzip gilt, jegliche chirurgische Prozedur von peripheren trigeminalen Strukturen beim episodischen ClusterKopfschmerz mit großer Vorsicht zu beurteilen, da die Erkrankung per definitionem remittiert. Kürzlich wurde auf der Basis von Bildgebungsverfahren erfolgreich die hypothalamische Tiefenhirnstimulation eingesetzt. Da es sich um eine experimentelle Therapie handelt, sollten die publizierten internationalen Konsensusrichtlinien für diese Prozedur bekannt sein und angewandt werden.

Summary

If all drug treatment procedures are ineffective anda secondary cluster headache (CH) has been excluded, surgical treatment can be discussed with the patient. Surgical procedures should be considered with great caution because no reliable long term observational data are available and because they can induce trigeminal neuralgia or anaesthesia dolorosa. However, there are also case reports of the complete inefficacy of surgical treatment in cluster headache and related syndromes. In some cases, blockade of the greater occipital nerve was effective and may be tried before any other surgical procedure. In general, any surgical procedure on peripheral trigeminal structures in episodic CH has to be judged with great caution, as the nature of the disease is to remit. Very recently, deep brain stimulation of the posterior inferior hypothalamus has been shown to be effective in the majority ofa sample of patients with intractable cluster headache. Recommendations for the selection of patients for this procedure have been published recently.

Schlüsselwörter

Tiefenhirnstimulation - Cluster-Kopfschmerz - Trigeminoautonome Kopfschmerzen - Therapie - invasiv

Keywords

Deep brain stimulation - cluster headache - trigeminoautonomic headache - therapy - interventional
 

  • Literatur

  • 1 Ambrosini A. et al. Suboccipital injection with a mixture of rapid- and long-acting steroids in cluster headache: a double-blind placebo-controlled study. Pain 2005; 118: 92-6.
    CrossrefPubMedGoogle Scholar
  • 2 Anthony M, Rose C. (ed.). Arrest of attacks of cluster headache by local steroid injection of the occipital nerve in Migraine. Basel: Karger; 1985: 169-73.
    Google Scholar
  • 3 Bahra A, Goadsby PJ. Diagnostic delays and mismanagement in cluster headache. Acta Neurol Scand 2004; 109: 175-9.
    CrossrefPubMedGoogle Scholar
  • 4 Bigo A, Delrieu F, Bousser MG. Treatment of vascular pain of the face by methylprednisolone injection into the area of the greater occipital nerve: 16 cases. Rev Neurol 1989; 145: 160-2.
    PubMedGoogle Scholar
  • 5 Black D. Dodick DW. Two cases of medically and surgically intractable SUNCT:a reason for caution and an argument for a central mechanism. Cephalalgia 2002; 03: 201-4.
    Google Scholar
  • 6 Bussone G. et al. Double-blind comparison of lithium and verapamil in cluster headache prophylaxis. Headache 1990; 30: 411-7.
    CrossrefPubMedGoogle Scholar
  • 7 Chazot G. et al. Chronobiological study of melatonin, cortisol, growth hormone and prolactin secretion in cluster headache. Cephalalgia 1984; 04: 213-20.
    CrossrefPubMedGoogle Scholar
  • 8 Di Sabato F, Fusco BM, Pelaia P, Giacovazzo M. Hyperbaric oxygen therapy in cluster headache. Pain 1993; 52: 243-5.
    CrossrefPubMedGoogle Scholar
  • 9 Donnet A, Valade D, Regis J. Gamma knife treatment for refractory cluster headache: prospective open trial. J Neurol Neurosurg Psychiatry 2005; 76: 218-21.
    CrossrefPubMedGoogle Scholar
  • 10 Ekbom K. Lithium for cluster headache: review of the literature and preliminary results of long-term treatment. Headache 1981; 02: 132-9.
    Google Scholar
  • 11 Ekbom K. Treatment of acute cluster headache with sumatriptan. N Eng J Med 1991; 325: 322-6.
    CrossrefPubMedGoogle Scholar
  • 12 Ekbom K, Waldenlind E, Cole J, Pilgrim A, Kirkham A. Sumatriptan in chronic cluster headache: results of continuous treatment for eleven months. Cephalalgia 1992; 12: 254-6.
    CrossrefPubMedGoogle Scholar
  • 13 Fogan L. Treatment of cluster headache. A doubleblind comparison of oxygen v. air inhalation.Arch Neurol 1985; 42: 362-3.
    Google Scholar
  • 14 Ford RG, Ford KT, Swaid S, Young P, Jennelle P. Gamma knife treatment of refractory cluster headache. Headache 1998; 38: 3-9.
    CrossrefPubMedGoogle Scholar
  • 15 Förderreuther S, Mayer M, Straube A. Treatment of cluster headache with topiramate: effects and side-effects in five patients. Cephalalgia 2002; 22: 186-9.
    CrossrefPubMedGoogle Scholar
  • 16 Franzini A. et al. Deep brain stimulation for intractable chronic cluster headache relief: preliminary results. J Neurol 2002; 249: 64.
    CrossrefPubMedGoogle Scholar
  • 17 Fusco BM, Giacovazzo M. Peppers and pain. The promise of capsaicin. Drugs 1997; 53: 909-14.
    PubMedGoogle Scholar
  • 18 Fusco BM, Marabini S, Maggi CS, Fiore G, Geppetti P. Preventative effect of repeated nasal applications of capsaicin in cluster headache. Pain 1994; 59: 321-5.
    CrossrefPubMedGoogle Scholar
  • 19 Gabai IJ, Spierings EL. Prophylactic treatment of cluster headache with verapamil. Headache 1989; 29: 167-8.
    CrossrefPubMedGoogle Scholar
  • 20 Goadsby PJ. Short-lasting primary headaches: focus on trigeminal automatic cephalgias and indomethacin-sensitive headaches. Curr Opin Neurol 1999; 12: 273-7.
    CrossrefPubMedGoogle Scholar
  • 21 Goadsby PJ. Trigeminal autonomic cephalgias (TACs). Acta Neurol Belg 2001; 101: 10-9.
    PubMedGoogle Scholar
  • 22 Goadsby PJ, Bahra A, May A. Mechanisms of cluster headache. Cephalalgia 1999; (Suppl. 19) 23: 19-21 discussion 21–3.
    Google Scholar
  • 23 Goadsby PJ, Edvinsson L. Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain 1994; 117: 427-34.
    PubMedGoogle Scholar
  • 24 Goadsby PJ, Lipton RB. A review of paroxysmal hemicranias, SUNCT syndrome and other shortlasting headaches with autonomic feature, including new cases. Brain 1997; 120: 193-209.
    CrossrefPubMedGoogle Scholar
  • 25 Hardebo JE, Moskowitz MA. Synthesis of cluster headache pathophysiology. In: Olesen J, TfeltHansen P, Welc KMA. (eds). The headaches. New York: Raven Press; 1993: 569-76.
    Google Scholar
  • 26 Headache Classification Committee of the International Headache Society. The International Classification of Headache Disorders. 2ndedition.. Cephalalgia: 2004. 24(Supplement 1): 1-160.
    Google Scholar
  • 27 Horton B, Craig W. A new syndrome of vascular headache: results of treatment with histamine: preliminary report. Mayo Clin Proc 1939; 14: 257-60.
    Google Scholar
  • 28 Jarrar RG, Black DF, Dodick DW, Davis DH. Outcome of trigeminal nerve section in the treatment of chronic cluster headache. Neurology 2003; 60: 1360-2.
    CrossrefPubMedGoogle Scholar
  • 29 Kudrow L. Cluster headache: diagnosis and management. Headache 1979; 19: 142-50.
    CrossrefPubMedGoogle Scholar
  • 30 Kudrow L. Response of cluster headache attacks to oxygen inhalation. Headache 1981; 21: 1-4.
    CrossrefPubMedGoogle Scholar
  • 31 Leone M. et al. Verapamil in the prophylaxis of episodic cluster headache: a doubleblind study versus placebo. Neurology 2000; 56: 1382-5.
    Google Scholar
  • 32 Leone M, Franzini A, Broggi G, Bussone G. Hypothalamic deep brain stimulation for intractable chronic cluster headache: a 3-year follow-up. Neurol Sci 2003; 24 (Suppl. 02) 143-5.
    Google Scholar
  • 33 Leone M, Franzini A, Broggi G, Bussone G. Hypothalamic stimulation for intractable cluster headache: long-term experience. Neurology 2006; 67: 150-2.
    CrossrefPubMedGoogle Scholar
  • 34 Leone M, Franzini A, Broggi G, May A, Bussone G. Long-term follow-up of bilateral hypothalamic stimulation for intractable cluster headache. Brain 2004; 120: 2259-64.
    Google Scholar
  • 35 Leone M. et al. Deep brain stimulation for intractable chronic cluster headache: proposals for patient selection. Cephalalgia 2004; 24: 934-7.
    CrossrefPubMedGoogle Scholar
  • 36 Leone M, Patruno G, Vescovi A, Bussone G. Neuroendocrine dysfunction in cluster headache. Cephalalgia 1990; 10: 235-9.
    CrossrefPubMedGoogle Scholar
  • 37 Lovely TJ, Kotsiakis X, Jannetta PJ. The surgical management of chronic cluster headache. Headache 1998; 38: 590-4.
    CrossrefPubMedGoogle Scholar
  • 38 Marks DR. et al. A double-blind placebo-controlled trial of intranasal capsaicin for cluster headache. Cephalalgia 1993; 13: 114-6.
    CrossrefPubMedGoogle Scholar
  • 39 Matharu MS, Goadsby PJ. Persistence of attacks of cluster headache after trigeminal nerve root section. Brain 2002; 125: 976-84.
    CrossrefPubMedGoogle Scholar
  • 40 Mathew NT, Hurt W. Percutaneous radiofrequency trigeminal gangliorhizolysis in intractable cluster headache. Headache 1988; 28: 328-31.
    CrossrefPubMedGoogle Scholar
  • 41 May A. Das trigeminovaskuläre System des Menschen: Zerebraler Blutfluss, funktionelle Bildgebung und primäre Kopfschmerzen. Nervenarzt 2003; 74: 1067-77.
    CrossrefPubMedGoogle Scholar
  • 42 May A. Cluster headache: pathogenesis, diagnosis, and management. Lancet 2005; 366: 843-55.
    CrossrefPubMedGoogle Scholar
  • 43 May A. Functional anatomy of headache. Neurol Sci 2006; 27 (Suppl. 02) 103-6.
    CrossrefPubMedGoogle Scholar
  • 44 May A. et al. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med 1999; 05: 836-8.
    CrossrefPubMedGoogle Scholar
  • 45 May A, Buchel C, Turner R, Goadsby PJ. Magnetic resonance angiography in facial and other pain: neurovascular mechanisms of trigeminal sensation. J Cereb Blood Flow Metab 2001; 21: 1171-6.
    CrossrefPubMedGoogle Scholar
  • 46 May A, Evers S, Straube A, Pfaffenrath V, Diener HC. Therapie und Prophylaxe von Cluster Kopfschmerzen und anderen Trigemino-autonomen Kopfschmerzen. Überarbeitete Empfehlungen der Deutschen Migräne- und Kopfschmerzgesellschaft. Nervenheilkunde 2004; 23: 478-90.
    Google Scholar
  • 47 May A, Goadsby PJ. Hypothalamic involvement and activation in cluster headache. Curr Pain Headache Rep 2001; 05: 60-6.
    CrossrefPubMedGoogle Scholar
  • 48 May A. et al. Hypothalamic deep brain stimulation in positron emission tomography. J Neurosci 2006; 26: 3589-93.
    CrossrefPubMedGoogle Scholar
  • 49 May A, Vesper J, Hamel W, Westphal M, Weiller C, Nikkhah G. Hypothalamische Tiefenhirnstimulation bei Patienten mit chronischen Cluster Kopfschmerzen: Vorschläge zur Patientenselektion. Der Schmerz 2005; 19: 544-8.
    CrossrefPubMedGoogle Scholar
  • 50 Mayberg MR, Zervas NT, Moskowitz NA. Trigeminal projections to supratentorial pial and dural blood vessels in cats demonstrated by horseradish peroxidase histochemistry. J Comp Neurol 1984; 223: 46-56.
    CrossrefPubMedGoogle Scholar
  • 51 Onofrio BM. Campbell JK. Surgical treatment of chronic cluster headache. Mayo Clin Proc 1986; 61: 537-44.
    PubMedGoogle Scholar
  • 52 Peres MF, Stiles MA, Siow HC, Rozen TD. Young WB, Silberstein WB. Greater occipital nerve blockade for cluster headache. Cephalalgia 2002; 22: 520-2.
    PubMedGoogle Scholar
  • 53 Robbins L. Intranasal lidocaine for cluster headache. Headache 199; 35: 83-4.
    Google Scholar
  • 54 Rodriguez-Oroz MC. et al. Bilateral deep brain stimulation in Parkinson’s disease: a multicentre study with 4 years follow-up. Brain 2005; 128: 2240-9.
    CrossrefPubMedGoogle Scholar
  • 55 Rowed DW. Chronic cluster headache managed by nervus intermedius section. Headache 1990; 30: 401-6.
    CrossrefPubMedGoogle Scholar
  • 56 Schoenen JL. et al. Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action. Brain 2005; 128: 940-7.
    CrossrefPubMedGoogle Scholar
  • 57 Sicuteri F. et al. Beneficial effect of capsaicin application to the nasal mucosa in cluster headache. Clin J Pain 1989; 05: 49-53.
    CrossrefPubMedGoogle Scholar
  • 58 Sjaastad O. (ed.). Cluster Headache Syndrome. Major Problems in Neurology. Vol. volume23 London: WB Saunders Company Ltd; 1992
    Google Scholar
  • 59 Steiner TJ, Hering R, Couturier E, Davies P, Whitmarsh TE. Double-blind placebo-controlled trial of lithium in episodic cluster headache. Cephalalgia 1997; 17: 673-5.
    CrossrefPubMedGoogle Scholar
  • 60 Uddman R, Edvinsson L, Ekman R, Kingman T, McCulloch J. Innervation of the feline cerebral vasculature by nerve fibers containing calcitonin gene-related peptide: trigeminal origin and co-existence with substance P. Neurosci Lett 1985; 62: 131-6.
    CrossrefPubMedGoogle Scholar
  • 61 Vesper J, Chabardes S, Fraix V, Sunde N, Ostergaard K. Dual channel deep brain stimulation system (Kinetra) for Parkinson’s disease and essential tremor: a prospective multicentre open label clinical study. J Neurol Neurosurg Psychiatry 2002; 73: 275-80.
    CrossrefPubMedGoogle Scholar