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Nervenheilkunde 2007; 26(10): 861-866
DOI: 10.1055/s-0038-1626937
Arbeiten zum Schwerpunkt - Theme Articles
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Neurochemische Demenzdiagnostik – Quo vadis?

Neurochemical diagnostic of dementia - quo vadis?
J. Wiltfang
1   Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Universität Erlangen-Nürnberg, Erlangen
,
M. Bibl
2   Klinik für Psychiatrie und Psychotherapie der Rheinischen Kliniken Essen, Universität Duisburg-Essen
,
M. Maler
1   Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Universität Erlangen-Nürnberg, Erlangen
,
H.-W. Klafki
1   Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Universität Erlangen-Nürnberg, Erlangen
,
H. Esselmann
1   Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Universität Erlangen-Nürnberg, Erlangen
,
J. Kornhuber
1   Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Universität Erlangen-Nürnberg, Erlangen
,
P. Lewczuk
1   Klinik mit Poliklinik für Psychiatrie und Psychotherapie, Universität Erlangen-Nürnberg, Erlangen
› Author Affiliations
Further Information

Publication History

Publication Date:
19 January 2018 (online)

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Zusammenfassung

Die vorliegende Arbeit soll eine Übersicht über innovative diagnostische Ansätze der Neurochemischen Demenzdiagnostik (NDD) geben. Eine verbesserte Früh- und Differenzialdiagnostik demenzieller Erkrankungen ist unter dem Aspekt sich entwickelnder kausal orientierter Therapiestrategien für die Alzheimer-Demenz (AD) von Bedeutung. Dies betrifft insbesondere Patienten mit leichter kognitiver Beeinträchtigung, wo ein AD-typisches Demenzbiomarkerprofil die drohende AD bereits mindestens vier bis sieben Jahre vor Ausbruch des Demenzstadiums anzeigen kann. Ebenso besteht Bedarf an zusätzlichen Demenzbiomarkern für die verbesserte Differenzialdiagnostik anderer Frühstadien neurodegenerativer Demenzerkrankungen, wie frontotemporale Demenzen, Demenz mit Lewy-Körperchen und Parkinson-Demenz, oder aber für Demenzbiomarker, die eng mit dem Schweregrad der Demenz im Verlauf korrelieren. Bezüglich neuerer Forschungsansätze werden wir auch erste Ansätze einer blutbasierten NDD diskutieren und innovative methodische Ansätze der multiparametischen Diagnostik (Multiplex Assays) vorstellen.

Summary

This article focuses on innovative diagnostic applications in the field of neurochemical dementia diagnostics (NDD). Most importantly, the chance of reliable predictive dementia diagnostics by NDD will support the most effective use of forthcoming preventive therapeutic strategies. Here, CSFNDD is promising to identify patients with mild cognitive impairment (MCI) at high risk for incipient Alzheimer’s dementia (AD), who present with the AD-indicative neurochemical dementia marker pattern already 4 to7 years prior to the clinical manifestation of AD. There is additional demand for novel neurochemical dementia markers for improved early and differential diagnosis of other dementias like Fronto-temporal Lobe Degeneration (FTLD), Lewy- Body-Dementia, and Parkinson-Disease-Dementia as well as markers which correlate with the progression of dementia.

Finally we will discuss new approaches in blood-based NDD and give an overview of multiparametric neurochemical dementia diagnostics (multiplex assays).

Schlüsselwörter

Alzheimer-Demenz - Liquor zerebrospinalis - Biomarker - Tau-Protein - Amyloidpeptid - beta-Amyloidpeptid - klinische Neurochemie

Keywords

Alzheimer’s Dementia - cerebrospinal fluid - biomarkers - tau - amyloid - beta-amyloid peptides - clinical neurochemistry
 

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