Nervenheilkunde 2014; 33(01/02): 57-63
DOI: 10.1055/s-0038-1627670
Schwabinger Neuroseminar
Schattauer GmbH

Ich sehe was, was Du nicht siehst

Physiologie und Differenzialdiagnose visueller Halluzinationen bei neurologischen ErkrankungenI spy with my little eyePhysiology and differential diagnosis of visual hallucinations in neurological disorders
M. Paulig
1   Abteilung für Neurologie und klinische Neurophysiologie, Schön Klinik, München Schwabing
› Institutsangaben
Weitere Informationen

Publikationsverlauf

eingegangen am: 30. August 2013

angenommen am: 05. September 2013

Publikationsdatum:
23. Januar 2018 (online)

Zusammenfassung

Visuelle Halluzinationen sind ein häufiges Begleitsymptom verschiedener Erkrankungen des Gehirns oder des Auges. Sie können als ein phänomenologisches Korrelat der funktionellen Hirnanatomie, insbesondere des visuellen Systems betrachtet werden. Sogar bei gesunden Menschen kann es unter Bedingungen einer beeinträchtigten Vigilanz oder sensorischer Deprivation zu visuellen Halluzinationen kommen. Dies legt nahe, dass sie der normalen visuellen Informationsverarbeitung im Gehirn inhärent sind. Die Kenntnis ihrer Semiologie und Neurobiologie verschafft dem Neurologen ein hilfreiches Rüstzeug bei der Läsionslokalisation und Differenzialdiagnose. Dieser Artikel setzt seinen Fokus auf häufige Störungsbilder in der neurologischen Praxis, z. B. Migräne, Epilepsie, Störungen der Schlafarchitektur, Charles-Bonnet-Syndrom und neurodegenerative Erkrankungen. Abgesehen davon können visuelle Halluzinationen im psychiatrischen Klientel, z. B. bei Schizophrenie oder Substanzgebrauch, vorkommen, was in diesem Artikel nicht vertieft wird.

Summary

Visual hallucinations are common attending ills in different acute and chronic diseases affecting the brain or the eye. They may be considered as phenomenological correlates of the cerebral functional architecture particularly of the visual system. Even in healthy subjects visual hallucinations can occur during impaired vigilance or sensory deprivation indicating that they are inherent in the normal processing of visual information in the brain. The knowledge of their semiology and neurobiology provides the neurologist with a useful armamentarium for lesion localization and differential diagnosis. This article focusses on frequent disorders in neurological practice, e.g. migraine, epilepsy, sleep disorders, Charles Bonnet syndrome, and neuro-degenerative diseases. Apart from that, visual hallucinations may also occur in psychiatric clients with for instance schizophrenia or substance abuse. These disorders are not addressed by this paper.

 
  • Literatur

  • 1 Adcock JE, Panayiotopoulos CP. Occipital lobe seizures and epilepsies. J Clin Neurophysiol 2012; 29 (05) 397-407.
  • 2 Allen P, Larøi F, McGuire PK, Aleman A. The hallucinating brain: a review of structural and functional neuroimaging studies of hallucinations. Neurosci Biobehav Rev 2008; 32 (01) 175-91.
  • 3 Alvaro LC. Hallucinations and pathological visual perceptions in Maupassant’s fantastical short stories – a neurological approach. J Hist Neurosci 2005; 14 (02) 100-15.
  • 4 Anton G. Über die Selbstwahrnehmung der Herd-erkrankungen des Gehirns durch den Kranken bei Rindenblindheit und Rindentaubheit. Arch Psychiat Nervenkr 1898; 32: 86-127.
  • 5 Anzellotti F. et al. Autoscopic phenomena: case report and review of literature. Behav Brain Funct 2011; 07 (01) 2.
  • 6 Arnulf I. Dream imagery, rapid eye movement sleep behavior disorder, and hallucinations. Sleep and Biological Rhythms. 2013: 1-6.
  • 7 Belcastro V. et al. Palinopsia in patients with migraine: a case-control study. Cephalalgia 2011; 31 (09) 999-1004.
  • 8 Benke T. Peduncular hallucinosis: a syndrome of impaired reality monitoring. J Neurol 2006; 253 (12) 1561-71.
  • 9 Benson MT, Rennie IG. Formed hallucination in the hemianopic field. Postgrad Med J 1989; 65 (768) 756-7.
  • 10 Borruat FX. Visual hallucinations and illusions, symptoms frequently misdiagnosed by the practitioner. Klin Monatsbl Augenheilkd 1999; 214: 324-27.
  • 11 Bronnick K. et al. Cognitive correlates of visual hallucinations in dementia associated with Parkinson’s disease. Mov Disord 2011; 26 (05) 824-9.
  • 12 Cochen V. et al. Vivid dreams, hallucinations, psychosis and REM sleep in Guillain-Barré syndrome. Brain 2005; 128 (Pt 11): 2535-45.
  • 13 Daniel C, Donnet A. Migrainous complex hallucinations in a 17-year-old adolescent. Headache 2011; 51 (06) 999-1001.
  • 14 de Morsier G. Les automatismes visuels. (Hallucinations visuelles rétrochiasmatiques). Schweizerische Medizinische Wochenschr 1936; 66: 700-703.
  • 15 Fahle M. Visuelle Täuschungen. In: Karnath, Thier (Hrsg.) Neuropsychologie. Berlin: Springer; 2006: 66-83.
  • 16 Fénelon G. et al. Feeling of presence in Parkinson’s disease. J Neurol Neurosurg Psychiatry 2011; 82 (11) 1219-24.
  • 17 Ffytche D. Visual hallucinatory syndromes – Visual hallucinatory syndromes: past, present, and future. Dialogues in Clinical Neuroscience 2007; 09 (02) 173-89.
  • 18 Forsaa EB. et al. A 12-year population-based study of psychosis in Parkinson disease. Arch Neurol 2010; 67: 996-1001.
  • 19 Hamilton JM. et al. Early visuospatial deficits predict the occurrence of visual hallucinations in autopsy-confirmed dementia with Lewy bodies. Am J Geriatr Psychiatry 2012; 20 (09) 773-81.
  • 20 Hashemi N, Zhang J, Gelman R, Lee AG. Visual hallucinations (Charles Bonnet syndrome) as the presenting sign of pituitary adenoma. Can J Ophthalmol 2012; 47 (03) e5-6.
  • 21 Hoque R, Liendo C, Chesson Jr AL. A girl who sees dead people. J Clin Sleep Med 2009; 05 (03) 277-9.
  • 22 Kanwisher N, Yovel G. The fusiform face area: a cortical region specialized for the perception of faces. Philos Trans R Soc Lond B Biol Sci 2006; 361 1476 2109-28.
  • 23 Kartsounis LD, James-Galton M, Plant GT. Anton syndrome, with vivid visual hallucinations, associated with radiation induced leucoencephalopathy. J Neurol Neurosurg Psychiatry 2009; 80 (08) 937-8.
  • 24 Kazui H. et al. Neuroimaging studies in patients with Charles Bonnet Syndrome. Psychogeriatrics 2009; 09 (02) 77-84.
  • 25 Koerts J. et al. Attentional and perceptual impairments in Parkinson’s disease with visual hallucinations. Parkinsonism Relat Disord 2010; 16 (04) 270-4.
  • 26 Kurita A, Murakami M, Takagi S, Matsushima M, Suzuki M. Visual hallucinations and altered visual information processing in Parkinson disease and dementia with Lewy bodies. Mov Disord 2010; 25 (02) 167-71.
  • 27 L’Hermitte J, De Ajuriaguerra J. Hallucinations visuelles et lésions de l’appareil visuel. Ann Médico-Psychologique 1936; 94: 321-351.
  • 28 Lapid M. et al. Clinical phenomenology and mortality in Charles Bonnet syndrome. J Geriatr Psychiatry Neurol 2013; 26 (01) 3-9.
  • 29 Liester MB. Toward a new definition of hallucination. Am J Orthopsychiatry 1998; 68 (02) 305-12.
  • 30 Manford M, Andermann F. Complex visual hallucinations. Clinical and neurobiological insights. Brain 1998; 121 (Pt 10): 1819-40.
  • 31 Mende W, Ploeger A. Das Verhalten und Erleben von Bergleuten in der Extrembelastung des Eingeschlossenseins. Nervenarzt 1966; 37 (05) 209-19.
  • 32 Menon B. Symptomatic occipital epilepsy misdiagnosed as migraine. Headache 2007; 47 (02) 287-9.
  • 33 Morgante L. et al. Psychosis associated to Parkinson’s disease in the early stages: relevance of cognitive decline and depression. J Neurol Neurosurg Psychiatry 2012; 83 (01) 76-82.
  • 34 Mortimer MJ, Kay J, Jaron A. Epidemiology of headache and childhood migraine in an urban general practice using Ad Hoc, Vahlquist and IHS criteria. Dev Med Child Neurol 1992; 34 (12) 1095-101.
  • 35 Nagy H. et al. The effect of dopamine agonists on adaptive and aberrant salience in Parkinson’s disease. Neuropsychopharmacology 2012; 37 (04) 950-8.
  • 36 Nishino S. Narcolepsy: pathophysiology and pharmacology. J Clin Psychiatry 2007; 68 (Suppl. 13) 9-15.
  • 37 Paciaroni M. Visual experiences of Blaise Pascal. Front Neurol Neurosci 2010; 27: 160-7.
  • 38 Palmqvist S. et al. Association between subcortical lesions and behavioral and psychological symptoms in patients with Alzheimer’s disease. Dement Geriatr Cogn Disord 2011; 32 (06) 417-23.
  • 39 Panayiotopoulos CP. Elementary visual hallucinations in migraine and epilepsy. J Neurol Neurosurg Psychiatry 1994; 57 (11) 1371-4.
  • 40 Perez-Lloret S, Rey MV, Ratti L, Rascol O. Pramipexole for the treatment of early Parkinson’s disease. Expert Rev Neurother 2011; 11 (07) 925-35.
  • 41 Ribstein M. Hypnagogic hallucinations. In: Guilleminault C, Dement WC, Passouant P. (eds.) Narcolepsy. New York: Spectrum; 1976: 145-160.
  • 42 Schadlu AP, Schadlu R, Shepherd JB. Charles Bonnet syndrome: a review. Curr Opin Ophthalmol 2009; 20 (03) 219-22.
  • 43 Schott GD. Exploring the visual hallucinations of migraine aura: the tacit contribution of illustration. Brain 2007; 130 (Pt 6): 1690-703.
  • 44 Shin S. et al. Neuroanatomical substrates of visual hallucinations in patients with non-demented Parkinson’s disease. J Neurol Neurosurg Psychiatry 2012; 83 (12) 1155-61.
  • 45 Shine JM, Halliday GM, Naismith SL, Lewis SJ. Visual misperceptions and hallucinations in Parkinson’s disease: dysfunction of attentional control networks?. Mov Disord 2011; 26 (12) 2154-9.
  • 46 Takata K, Inoue Y, Hazama H, Fukuma E. Nighttime hypnopompic visual hallucinations related to REM sleep disorder. Psychiatry Clin Neurosci 1998; 52: 207-209.
  • 47 Taylor I, Scheffer IE, Berkovic SF. Occipital epilepsies: identification of specific and newly recognized syndromes. Brain 2003; 126 (Pt 4): 753-69.
  • 48 Teunisse F. et al. Visual hallucinations in psychologically normal people: Charles Bonnet`s syndrome. Lancet 1996; 347: 794-97.
  • 49 Todd J. The syndrome of Alice in Wonderland. Can Med Assoc J 1955; 73 (09) 701-4.
  • 50 Uguccioni G. et al. Fight or flight? Dream content during sleepwalking/sleep terrors vs rapid eye movement sleep behavior disorder. Sleep Med 2013; 14 (05) 391-8.
  • 51 Viana M. et al. The typical duration of migraine aura: A systematic review. Cephalalgia 2013; 33 (07) 483-90.
  • 52 Wadsworth LP. et al. Neuropsychiatric symptoms and global functional impairment along the Alzheimer’s continuum. Dement Geriatr Cogn Disord 2012; 34 (02) 96-111.
  • 53 Wang RC, Katz SE, Lubow M. Visual loss and central venous catheterization: cortical blindness and hemianopsia after inadvertent subclavian artery entry. J Neuroophthalmol 2000; 20 (01) 32-4.
  • 54 Wills L, Garcia J. Parasomnias: epidemiology and management. CNS Drugs 2002; 16 (12) 803-10.
  • 55 Winawer MR, Connors R. EPGP Investigators. Evidence for a shared genetic susceptibility to migraine and epilepsy. Epilepsia 2013; 54 (02) 288-95.
  • 56 Wunderlich G. et al. Visual hallucinations in recovery from cortical blindness: imaging correlates. Arch Neurol 2000; 57 (04) 561-5.
  • 57 Zanigni S. et al. REM behaviour disorder and neurodegenerative diseases. Sleep Med 2011; 12 (Suppl. 02) S54-8.
  • 58 Zihl J. Visuelle Reizerscheinungen. In: Karnath, Thier (Hrsg.) Neuropsychologie. Berlin: Springer; 2006: 84-87l.