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DOI: 10.1055/s-0038-1627756
Vitamin D und Multiple Sklerose
Fakten und FiktionVitamin D and multiple sclerosisPublication History
eingegangen am:
15 August 2014
angenommen am:
19 August 2014
Publication Date:
22 January 2018 (online)
Zusammenfassung
Epidemiologische Daten unterstützen einen möglichen Zusammenhang zwischen einem Vitamin-D-Mangel und einem erhöhten Risiko für Multiple Sklerose (MS) und andere Autoimmunerkrankungen. Obwohl kleine klinische Studien Vitamin D als einen wesentlichen Faktor für die Verhinderung von Schüben und Krankheitsprogression bei MS identifiziert haben, fehlen noch Ergebnisse prospektiver, randomisierter, kontrollierter Studien, um diese Effekte zu bestätigen und die optimale therapeutisch wirksame Vitamin-D-Dosis auch unter Berücksichtigung von Sicherheitsaspekten zu identifizieren.
Wir geben einen Überblick über Vitamin D und seinen Metabolismus, Ergebnisse präklinischer In-vitro-und In-vivo-Studien zu immunmodulatorischen Effekten von Vitamin D und berichten über die Ergebnisse erster klinischer Studien zu verlaufsmodifizierenden Effekten von Vitamin D bei Patienten mit MS. Es folgen praktische Empfehlungen zur Handhabung von Vitamin D bei Patienten mit MS bis zum Vorliegen belastbarer klinischer Daten aus prospektiven, randomisierten und kontrollierten Studien.
Summary
Epidemiologic data support an association between vitamin D deficiency and the risk of developing multiple sclerosis and other autoimmune diseases. Although smaller scale studies identified vitamin D to be effective in lowering the risk of relapses and clinical progression in multiple sclerosis, data from prospective randomized controlled clinical trials corroborating the described effects and determining the most efficient dose are currently lacking.
We provide an overview on vitamin D and its metabolism, results from preclinical in vitro and in vivo studies concerning immunomodulatory effects of vitamin D as well as results from first clinical studies regarding disease-modifying effects in patients with multiple sclerosis. Finally, we provide preliminary advice how to handle vitamin D assessment and substitution in patients with multiple sclerosis until above mentioned results from prospective large-scale clinical trials are available.
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