Download PDF
Osteologie 2017; 26(04): 236-243
DOI: 10.1055/s-0038-1628305
Osteomyelitis
Schattauer GmbH

Osteomyelitis der Kieferknochen

Osteomyelitis of the jaws
T. K. Kakoschke
1   Klinik und Poliklinik für Mund, -Kiefer- und Gesichtschirurgie, Klinikum der Universität München, München
,
S. Aljohani
1   Klinik und Poliklinik für Mund, -Kiefer- und Gesichtschirurgie, Klinikum der Universität München, München
,
G. Kaeppler
1   Klinik und Poliklinik für Mund, -Kiefer- und Gesichtschirurgie, Klinikum der Universität München, München
,
M. Ehrenfeld
1   Klinik und Poliklinik für Mund, -Kiefer- und Gesichtschirurgie, Klinikum der Universität München, München
,
S. Otto
1   Klinik und Poliklinik für Mund, -Kiefer- und Gesichtschirurgie, Klinikum der Universität München, München
› Author Affiliations
Further Information

Publication History

eingegangen: 11 October 2017

angenommen: 13 January 2017

Publication Date:
24 January 2018 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Entzündliche Erkrankungen des Kieferknochens stellen eine relevante klinische Herausforderung dar. Die Therapieoptionen und vor allem die Erfolgschancen unterscheiden sich hierbei je nach zugrunde liegender Entität. Die prophylaktischen Maßnahmen ähneln sich hingegen und umfassen vor allem eine optimale Mundhygiene sowie die adäquate Therapie von dentogenen Infektionen. Dieser Artikel gibt eine Übersicht über den aktuellen Kenntnisstand zu den verschiedenen Formen der entzündlichen Erkrankungen des Kiefers und ihre Unterschiede zu Osteomyelitiden anderer Körperregionen. Ein fächerübergreifendes Wissen sowie eine interdisziplinäre Zusammenarbeit ist Voraussetzung für eine ideale Prophylaxe, das frühzeitige Erkennen, eine adäquate Versorgung und das Vermeiden von Komplikationen der Osteomyelitiden und Nekrosen der Kieferknochen.

Summary

Inflammatory diseases of the jaws are a clinical challenge. Therapeutic options and especially chances of success in treatment vary depending on the underlying entity. Prophylactics on the other hand are very similar. They include a good oral hygiene and care as well as an adequate therapy of dental infections. This article gives an overview of the state of knowledge concerning the various types of inflammatory diseases of the jaws and their differences to osteomyelitis of other body regions. An interdisciplinary knowledge and collaborations are essential for preventing, detecting and treating osteomyelitis or osteonecrosis of the jaw and to avoid major complications.

Schlüsselwörter

Osteomyelitis - Knochenmarkentzündung - Osteonekrose - medikamentenassoziierte Osteonekrose des Kiefers (MRONJ) - Bisphosphonate - Denosumab - Osteoradionekrose

Keywords

Osteomyelitis - infection and inflammation of the bone - osteonecrosis - medication-related osteonecrosis of the jaw (MRONJ) - bisphosphonates - Denosumab - osteoradionecrosis
 

  • Literatur

  • 1 Nicholson S. et al., Aspergillus Osteomyelitis of the Skull. J Craniofac Surg 2016; 27 (Suppl. 05) e504-e506.
    CrossrefPubMedSearch in Google Scholar
  • 2 Richaud C. et al. Candida vertebral osteomyelitis (CVO) 28 cases from a 10-year retrospective study in France. Medicine (Baltimore) 2017; 96 (31) e7525.
    CrossrefPubMedSearch in Google Scholar
  • 3 Rammaert B. et al. Dimorphic fungal osteoarticular infections. Eur J Clin Microbiol Infect Dis 2014; 33 (12) 2131-2140.
    CrossrefPubMedSearch in Google Scholar
  • 4 Bariteau JT. et al. Fungal osteomyelitis and septic arthritis. J Am Acad Orthop Surg 2014; 22 (Suppl. 06) 390-401.
    CrossrefPubMedSearch in Google Scholar
  • 5 Tabrizi R. et al. Herpes Zoster Induced Osteomyelitis in the Immunocompromised Patients: A 10-year Multicenter Study. J Dent (Shiraz) 2014; 15 (Suppl. 03) 112-116.
    Search in Google Scholar
  • 6 Kahn MF, Kahn MA. The SAPHO syndrome. Bail-lieres Clin Rheumatol 1994; 8 (Suppl. 02) 333-362.
    CrossrefPubMedSearch in Google Scholar
  • 7 Jansson A. et al., Chronisch rezidivierende multi-fokale Osteomyelitis und andere nichtbakterielle Osteitiden: Klinik, Diagnostik, Therapie, Prognose und genetische Untersuchungen. Dtsch Arztebl. 2004 101(9): A-584 / B-483 / C-475.
    PubMedSearch in Google Scholar
  • 8 Woodacre T. and T. Mason, Acute-on-Chronic Osteomyelitis of the Scapula Treated via Trephi-nation. J Trauma Treat. 3:199. doi:10.4172/2167–1222.1000199, 2014
    PubMedSearch in Google Scholar
  • 9 Graubner B. ICD-10-GM 2014 Systematisches Verzeichnis Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme 11. Revision – German Modification Version. 2014 Deutscher Ärzteverlag 2013
    PubMedSearch in Google Scholar
  • 10 Schelhorn P, Zenk W. [Clinics and therapy of the osteomyelitis of the lower jaw]. Stomatol DDR 1989; 39 (10) 672-676.
    PubMedSearch in Google Scholar
  • 11 Marx RE. Chronic osteomyelitis of the jaws. Oral Maxillofac Clin North Am 1991; 3: 367-381.
    Search in Google Scholar
  • 12 Mercuri LG. Acute osteomyelitis of the jaw. Oral Maxillofac Surg Clin North Am 1991; 3: 355-365.
    Search in Google Scholar
  • 13 Bernier S. et al. Osteomyelitis of the jaws. J Can Dent Assoc 1995; 61 (Suppl. 05) 441-442. 445-448.
    PubMedSearch in Google Scholar
  • 14 Suei Y, Taguchi A, Tanimoto K. Diagnosis and classification of mandibular osteomyelitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 100 (Suppl. 02) 207-214.
    CrossrefPubMedSearch in Google Scholar
  • 15 Hudson JW. Osteomyelitis of the jaws: a 50-year perspective. J Oral Maxillofac Surg 1993; 51 (12) 1294-1301.
    CrossrefPubMedSearch in Google Scholar
  • 16 Baltensperger M. et al. Is primary chronic osteomyelitis a uniform disease? Proposal of a classification based on a retrospective analysis of patients treated in the past 30 years. J Craniomaxillofac Surg 2004; 32 (Suppl. 01) 43-50.
    CrossrefPubMedSearch in Google Scholar
  • 17 Freudlsperger C, Hoffmann J. Osteomyelitis der Kiefer. Zahnärztliche Mitteilungen – zm online. 2014 Deutscher Ärzteverlag.
    PubMedSearch in Google Scholar
  • 18 Olson ME, Horswill AR. Staphylococcus aureus osteomyelitis: bad to the bone. Cell Host Microbe 2013; 13 (Suppl. 06) 629-631.
    CrossrefPubMedSearch in Google Scholar
  • 19 Pigrau C. et al. Osteomyelitis of the jaw: resistance to clindamycin in patients with prior antibiotics exposure. Eur J Clin Microbiol Infect Dis 2009; 28 (Suppl. 04) 317-323.
    CrossrefPubMedSearch in Google Scholar
  • 20 Gaetti-Jardim Junior E. et al. Microbiota associated with chronic osteomyelitis of the jaws. Braz J Microbiol, 2010; 41 (Suppl. 04) 1056-1064.
    CrossrefPubMedSearch in Google Scholar
  • 21 Pincus DJ, Armstrong MB, Thaller SR. Osteomyelitis of the craniofacial skeleton. Semin Plast Surg 2009; 23 (Suppl. 02) 73-79.
    Thieme ConnectPubMedSearch in Google Scholar
  • 22 Calhoun KH. et al. Osteomyelitis of the mandible. Arch Otolaryngol Head Neck Surg 1988; 114 (10) 1157-1162.
    CrossrefPubMedSearch in Google Scholar
  • 23 Uche C. et al. Osteomyelitis Of The Jaw: A Retrospective Analysis. The Internet Journal of Infectious Diseases. 2008 7 (2).
    PubMedSearch in Google Scholar
  • 24 Al-Maskari AY, Al-Maskari MY, Al-Sudairy S. Oral Manifestations and Complications of Diabetes Mellitus: A review. Sultan Qaboos Univ Med J 2011; 11 (Suppl. 02) 179-186.
    PubMedSearch in Google Scholar
  • 25 Dunphy DL, Frazer JP. Acute osteomyelitis of the maxilla in a newborn; report of a case successfully treated with penicillin and sulfadiazine. Yale J Biol Med 1947; 19 (Suppl. 05) 877-881.
    PubMedSearch in Google Scholar
  • 26 Wilensky AO. Osteomyelitis of the Jaws in Nurslings and Infants. Ann Surg 1932; 95 (Suppl. 01) 33-45.
    CrossrefPubMedSearch in Google Scholar
  • 27 Joseph PV, Haridas AK. Neonatal osteomyelitis with pathologic fracture of mandible following MRSA septicemia: management and three year follow up. J Maxillofac Oral Surg 2015; 14 (Suppl. 01) 77-80.
    CrossrefPubMedSearch in Google Scholar
  • 28 Tellez-Rodriguez J. et al. Mycobacterium tuberculosis as a cause of mandibular osteomyelitis in a young woman: a case report. J Med Case Rep 2016; 10 (Suppl. 01) 366.
    CrossrefPubMedSearch in Google Scholar
  • 29 Gupta R. et al. Tuberculous osteomyelitis of the maxilla: A rarest of rare case report. Natl J Maxillofac Surg 2014; 5 (Suppl. 02) 188-191.
    CrossrefPubMedSearch in Google Scholar
  • 30 Ivy RH, Curtis L. Congenital Syphilitic Osteomyelitis of the Mandible: A Report of two Analogous Cases in Sisters. Ann Surg 1934; 100 (Suppl. 03) 535-538.
    CrossrefPubMedSearch in Google Scholar
  • 31 Lore B. et al. A complication following tooth extraction: chronic suppurative osteomyelitis. Oral Implantol (Rome) 2013; 6 (Suppl. 02) 43-47.
    PubMedSearch in Google Scholar
  • 32 Lew DP, Waldvogel FA. Osteomyelitis. Lancet 2004; 364 9431 369-379.
    CrossrefPubMedSearch in Google Scholar
  • 33 Fritz JM, McDonald JR. Osteomyelitis: approach to diagnosis and treatment. Phys Sportsmed 2008; 36 (Suppl. 01) nihpa116823.
    CrossrefPubMedSearch in Google Scholar
  • 34 Pineda C, Espinosa R, Pena A. Radiographic imaging in osteomyelitis: the role of plain radiography, computed tomography, ultrasonography, magnetic resonance imaging, and scintigraphy. Semin Plast Surg 2009; 23 (Suppl. 02) 80-89.
    Thieme ConnectPubMedSearch in Google Scholar
  • 35 Garcia-Marin F, Iriarte-Ortabe JI, Reychler H. Chronic diffuse sclerosing osteomyelitis of the mandible or mandibular location of S.A.P.H.O. syndrome. Acta Stomatol Belg 1996; 93 (Suppl. 02) 65-71.
    PubMedSearch in Google Scholar
  • 36 Otto S. et al. Ibandronate treatment of diffuse sclerosing osteomyelitis of the mandible: Pain relief and insight into pathogenesis. J Craniomaxillofac Surg 2015; 43 (Suppl. 09) 1837-1842.
    CrossrefPubMedSearch in Google Scholar
  • 37 Jacobsson S, Dahlen G, Moller AJ. Bacteriologic and serologic investigation in diffuse sclerosing osteomyelitis (DSO) of the mandible. Oral Surg Oral Med Oral Pathol 1982; 54 (Suppl. 05) 506-512.
    CrossrefPubMedSearch in Google Scholar
  • 38 Svan Merkesteyn JP. et al. Diffuse sclerosing osteomyelitis of the mandible: a new concept of its etiology. Oral Surg Oral Med Oral Pathol 1990; 70 (Suppl. 04) 414-419.
    CrossrefPubMedSearch in Google Scholar
  • 39 Schultz C. et al. Chronic recurrent multifocal osteomyelitis in children. Pediatr Infect Dis J 1999; 18 (11) 1008-1013.
    CrossrefPubMedSearch in Google Scholar
  • 40 Otto S. Medication-Related Osteonecrosis of the Jaws. Springer; 2015
    Search in Google Scholar
  • 41 Ruggiero SL. et al. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw – 2014 update. J Oral Maxillofac Surg 2014; 72 (10) 1938-1956.
    CrossrefPubMedSearch in Google Scholar
  • 42 Otto S. et al. Osteoporosis and bisphosphonates- related osteonecrosis of the jaw: not just a sporadic coincidence--a multi-centre study. J Craniomaxillofac Surg 2011; 39 (Suppl. 04) 272-277.
    CrossrefPubMedSearch in Google Scholar
  • 43 Otto S. et al. Bisphosphonate-related osteonecrosis of the jaws – characteristics, risk factors, clinical features, localization and impact on oncological treatment. J Craniomaxillofac Surg 2012; 40 (Suppl. 04) 303-309.
    CrossrefPubMedSearch in Google Scholar
  • 44 Otto S. et al. Osteonecrosis of the jaw as a possible rare side effect of annual bisphosphonate administration for osteoporosis: A case report. J Med Case Rep 2011; 5: 477.
    CrossrefPubMedSearch in Google Scholar
  • 45 Then C. et al. Incidence and risk factors of bisphosphonate-related osteonecrosis of the jaw in multiple myeloma patients having undergone autologous stem cell transplantation. Onkologie 2012; 35 (11) 658-664.
    CrossrefPubMedSearch in Google Scholar
  • 46 Otto S. et al. Bisphosphonate-related osteonecrosis of the jaw: is pH the missing part in the pathogenesis puzzle?. J Oral Maxillofac Surg 2010; 68 (Suppl. 05) 1158-1161.
    CrossrefPubMedSearch in Google Scholar
  • 47 Otto S. et al. Osteonecrosis of the jaw: effect of bisphosphonate type, local concentration, and acidic milieu on the pathomechanism. J Oral Maxillofac Surg 2010; 68 (11) 2837-2845.
    CrossrefPubMedSearch in Google Scholar
  • 48 Marx RE. Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg 1983; 41 (Suppl. 05) 283-288.
    CrossrefPubMedSearch in Google Scholar
  • 49 Hanley ME, Cooper JS. Osteoradionecrosis, in StatPearls. Treasure Island; -(FL) 2017
    Search in Google Scholar
  • 50 Rathy R, Sunil S, Nivia M. Osteoradionecrosis of mandible: Case report with review of literature. Contemp Clin Dent 2013; 4 (Suppl. 02) 251-253.
    CrossrefPubMedSearch in Google Scholar
  • 51 Pautke C. et al. Tetracycline bone fluorescence: a valuable marker for osteonecrosis characterization and therapy. J Oral Maxillofac Surg 2010; 68 (Suppl. 01) 125-129.
    CrossrefPubMedSearch in Google Scholar
  • 52 Pautke C. et al. Fluorescence-guided bone resection in bisphosphonate-associated osteonecrosis of the jaws. J Oral Maxillofac Surg 2009; 67 (Suppl. 03) 471-476.
    CrossrefPubMedSearch in Google Scholar
  • 53 Otto S. et al. Fluorescence-guided surgery for the treatment of medication-related osteonecrosis of the jaw: A prospective cohort study. J Craniomaxillofac Surg 2016; 44 (Suppl. 08) 1073-1080.
    CrossrefPubMedSearch in Google Scholar
  • 54 Pautke C. et al. Fluorescence-guided bone resection in bisphosphonate-related osteonecrosis of the jaws: first clinical results of a prospective pilot study. J Oral Maxillofac Surg 2011; 69 (Suppl. 01) 84-91.
    CrossrefPubMedSearch in Google Scholar
  • 55 Montonen M. et al. Decortication in the treatment of diffuse sclerosing osteomyelitis of the mandible. Retrospective analysis of 41 cases between 1969 and 1990. Oral Surg Oral Med Oral Pathol 1993; 75 (Suppl. 01) 5-11.
    CrossrefPubMedSearch in Google Scholar
  • 56 Zwaenepoel T, Vlam K. SAPHO: Treatment options including bisphosphonates. Semin Arthritis Rheum 2016; 46 (Suppl. 02) 168-173.
    CrossrefPubMedSearch in Google Scholar