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Nervenheilkunde 2013; 32(01/02): 54-57
DOI: 10.1055/s-0038-1628472
Kasuistik
Schattauer GmbH

Acamprosat und Naltrexon als Kombinationstherapie bei Alkoholund Benzodiazepinabhängigkeit

Acamprosate and naltrexone as a combined therapy for alcohol and benzodiazepine dependence
M. Gahr
1   Klinik für Psychiatrie und Psychotherapie III, Universitätsklinikum Ulm
,
C. Schönfeldt-Lecuona
1   Klinik für Psychiatrie und Psychotherapie III, Universitätsklinikum Ulm
› Institutsangaben
Weitere Informationen

Publikationsverlauf

eingegangen am: 31. März 2012

angenommen am: 10. April 2012

Publikationsdatum:
22. Januar 2018 (online)

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Zusammenfassung

Acamprosat und Naltrexon sind etablierte Strategien zur pharmakologischen Rückfallprophylaxe bei Patienten mit Alkoholabhängigkeit. Obwohl die Kombination beider Substanzen bei dieser Indikation aufgrund pharmakodynamischer und -kinetischer Überlegungen eine sinnvolle Therapieoption darstellt, welche in klinischen Studien als effektiv und sicher beschrieben wurde, wird sie im klinischen Alltag selten eingesetzt. Wir berichten über eine erfolgreiche Behandlung von Acamprosat und Naltrexon bei einer Patientin mit einer schweren Alkohol-und Benzodiazepinabhängigkeit, welche unter dieser Therapie das längste Abstinenzintervall seit der Entwicklung ihrer Suchterkrankung erreichen konnte.

Summary

Acamprosate and naltrexone are established strategies for pharmacologic relapse prevention in patients with alcohol dependence. Regarding pharmacodynamic and -kinetic considerations the combination of both agents for this indication is a reasonable treatment option that has been described to be safe and effective in clinical studies. However, this combination is uncommon in clinical practice. We report the case of a patient with severe alcoholand benzodiazepine dependence who achieved her longest interval of abstinence under combined treatment with acamprosate and naltrexone since the development of her addiction.

Schlüsselwörter

Abhängigkeit - Abstinenz - Craving - Rückfallprophylaxe

Keywords

Addiction - abstinence - craving - relapse prevention
 

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