Hypertrophe Degeneration des Nucleus olivaris

Zusammenfassung

Die hypertrophe Degeneration der Oliven (HOD) ist eine seltene Form der Neuroplastizität, die als Folge von Läsionen des anatomisch-funktionellen Regelkreises des Guillan-Mollaret-Dreiecks, bestehend aus dem Nucleus ruber, dem ipsilateralen Nucleus olivaris inferior (ION) und dem kontralateralen Nucleus dentatus, auftritt. Dieser Artikel zeigt eine Übersicht der Literatur der HOD unter Berücksichtigung ätiologischer, pathophysiologischer und klinischer Aspekte. Darüber hinaus berichten wir von einem Patienten mit HOD, der mittels Videookulografie untersucht wurde.

Summary

Hypertrophic olivary degeneration (HOD) is a rare variant of trans-synaptic neuroplasticity that occurs secondary after focal lesions of the neurofunctional pathway referred to as the “Guillan-Mollaret triangle”, consisting of the red nucleus, the ipsilateral inferior olivary nucleus and contralateral cerebellar dentate nucleus. We present a case of a 55-year old patient with HOD along with Holmes`-Tremor and spontaneous nystagmus after a pontine haemorrhage including a detailed examination by means of videooculography. Moreover, we provide an overview of the recent literature regarding hypertrophic olivary degeneration and associated clinical symptoms.

Schlüsselwörter

Hypertrophe oliväre Degeneration - Holmes` Tremor - Nystagmus

Keywords

Hypertrophic olivary degeneration - Holmes` Tremor - nystagmus

• Literatur

• 1 Oppenheim H. Über Oliven Degeneration bei Atheromatose der basalen Hirnarterien. Berl Klin Wochenschr 1887; 34: 638-9.
• 2 Guillain G, Mollaret P. Deux cas de myoclonies synchones et rhythms velopharyngo-laryngooculo-diaphragmatiques. Rev Neurol. 1931: 545-66.
• 3 Hornyak M, Osborn AG, Couldwell WT. Hypertrophic olivary degeneration after surgical removal of cavernous malformations of the brain stem: report of four cases and review of the literature. Acta Neurochir (Wien) 2008; 150 (02) 149-56.
• 4 Goyal M. et al. Hypertrophic olivary degeneration: metaanalysis of the temporal evolution of MR findings. AJNR Am J Neuroradiol 2000; 21 (06) 1073-7.
• 5 Nieuwenhuys R, Voogd J, van Huijzen C. (eds.). The Human Central Nervous System. Berlin: Springer-Verlag; 2008
• 6 Kitajima M. et al. Hypertrophic olivary degeneration: MR imaging and pathologic findings. Radiology 1994; 192 (02) 539-43.
• 7 Duchen L. General pathology of neurons and neuralgia. Greenfield H et al. (eds). Neuropathology. New York, NY: Wiley; 1994
• 8 Krings T, Foltys H, Meister IG, Reul J. Hypertrophic olivary degeneration following pontine haemorrhage: hypertensive crisis or cavernous haemangioma bleeding?. J Neurol Neurosurg Psychiatry 2003; 74 (06) 797-9.
• 9 Goto N, Kaneko M. Olivary enlargement: chronological and morphometric analyses. Acta Neuropathol 1981; 54 (04) 275-82.
• 10 Carota A, Duron N, Cereda C, Bassetti CL. Vertical pendular nystagmus and hypertrophic inferior olivary nuclei degeneration: an “odd couple”. J Neurol 2012; 259 (02) 372-4.
• 11 Asal N. et al. Hypertrophic olivary degeneration after pontine hemorrhage. Neuroradiology 2012; 54 (04) 413-5.
• 12 Arora V. et al. Hypertrophic Olivary Degeneration Following Trauma – A Case Report. Ind J Radiol Imag 2006; 16 (05) 701-4.
• 13 Gerace C, Fele MR, Luna R, Piazza G. Neurological picture. Bilateral hypertrophic olivary degeneration. J Neurol Neurosurg Psychiatry 2006; Jan; 77 (01) 73.
• 14 Gatlin JL, Wineman R, Schlakman B, Buciuc R, Khan M. Hypertrophic olivary degeneration after resection of a pontine cavernous malformation: a case report. J Radiol Case Rep 2011; 05 (03) 24-9.
• 15 Birbamer G, Buchberger W, Felber S, Aichner F. MR appearance of hypertrophic olivary degeneration: temporal relationships. AJNR Am J Neuroradiol 1992; 13 (05) 1501-3.
• 16 Benedikt M. Tremblement avec paralysie croisée du moteur oculaire commun. Bull Med (Paris) 1889; 03: 547-8.
• 17 Holmes G. On certain tremors in organic cerebral lesions. Brain 1904; 27: 325-75.
• 18 Andrew J, Fowler CJ, Harrison MJ. Tremor after head injury and its treatment by stereotaxic surgery. J Neurol Neurosurg Psychiatry 1982; 45 (09) 815-9.
• 19 Mossuto-Agatiello L, Puccetti G, Castellano AE. “Rubral” tremor after thalamic haemorrhage. J Neurol 1993; 241 (01) 27-30.
• 20 Striano P, Elefante A, Coppola A, Tortora F, Zara F, Minetti C. Dramatic response to levetiracetam in post-ischaemic Holmes’ tremor. BMJ Case Rep. 2009 doi:10.1136/bcr.08.2008.0643.
• 21 Juengling FD, Kassubek J, Moser E, Nitzsche EU. Precise localization of dysfunctional areas in vertebro-basilar infarction by FDG-and O-15-H2O-PET using standardized image analysis and image registration to 3-D MR. Nuklearmedizin 1999; 38 (08) 341-4.
• 22 Rieder CR, Reboucas RG, Ferreira MP. Holmes tremor in association with bilateral hypertrophic olivary degeneration and palatal tremor: chronological considerations. Case report. Arq Neuropsiquiatr 2003; 61 (2B): 473-7.
• 23 Pinkhardt E, Kassubek J. Die Untersuchung der Okulomotorik als differenzialdiagnostisches Instrument bei Parkinson-Syndromen. Nervenheilkunde 2011; 30 (04) 259-62.
• 24 Shery T, Proudlock FA, Sarvananthan N, McLean RJ, Gottlob I. The effects of gabapentin and memantine in acquired and congenital nystagmus: a retrospective study. Br J Ophthalmol 2006; 90 (07) 839-43.
• 25 Oertel W, Deuschl G, Poewe W. (eds.). Parkinson-Syndrome und andere Bewegungsstörungen. GT Verlag GT: Stuttgart; 2012
• 26 Sanchez JHernandez. et al. Hypertrophic olivary degeneration secondary to a Guillain-Mollaret triangle lesion. Neurologia 2013; 28 (01) 59-61.
• 27 Salamon-Murayama N, Russell EJ, Rabin BM. Diagnosis please. Case 17: hypertrophic olivary degeneration secondary to pontine hemorrhage. Radiology 1999; 213 (03) 814-7.
• 28 Deuschl G, Bain P, Brin M. Consensus statement of the movement disorder society on tremor. Ad Hoc Scientific Committee. Mov Disord 1998; 13 (Suppl. 03) 2-23.
• 29 Habib Rur. Diagnosis and management of tremor. Arch Intern Med 2000; 160 (16) 2438-44.
• 30 Yang YW. et al. Clinical and magnetic resonance imaging manifestations of Holmes tremor. Acta Neurol Taiwan 2005; 14 (01) 9-15.
• 31 Lapresle J. Rhythmic palatal myoclonus and the dentato-olivary pathway. J Neurol 1979; 220 (04) 223-30.
• 32 Phatouros CC, McConachie NS. Hypertrophic olivary degeneration: case report in a child. Pediatr Radiol 1998; 28 (11) 830-1.
• 33 Akar S, Drappatz J, Hsu L, Blinder RA, Black PM, Kesari S. Hypertrophic olivary degeneration after resection of a cerebellar tumor. J Neurooncol 2008; 87 (03) 341-5.
• 34 Vaidhyanath R, Thomas A, Messios N. Bilateral hypertrophic olivary degeneration following surgical resection of a posterior fossa epidermoid cyst. Br J Radiol 2010; 83 (994) e211-5.
• 35 Bruno MK, Wooten GF. Hypertrophic olivary degeneration. Arch Neurol 2012; 69 (02) 274-5.
• 36 Lim CC, Lim SA. Images in clinical medicine. Pendular nystagmus and palatomyoclonus from hypertrophic olivary degeneration. N Engl J Med 2009; 360 (09) e12.
• 37 Jang L, Borruat FX. Micronystagmus of oculopalatal tremor. Neurology 2013; 80 (03) e27.
• 38 Cho HJ, Choi HY, Kim YD, Seo SW, Heo JH. The clinical syndrome and etiological mechanism of infarction involving the nucleus prepositus hypoglossi. Cerebrovasc Dis 2008; 26 (02) 178-83.
• 39 Glasauer S, Dieterich M, Brandt T. Modeling the role of the interstitial nucleus of Cajal in otolithic control of static eye position. Acta Otolaryngol Suppl 2001; 545: 105-7.
• 40 Leigh RJ, Zee DS. The Neurology of Eye Movements. New York: Oxford University Press; 2006.
• 41 Shaikh AG. et al. Oculopalatal tremor explained by a model of inferior olivary hypertrophy and cerebellar plasticity. Brain 2010; 133 (Pt 3): 923-40.
• 42 DGN DGfN. www.dgn.org/component/content/article/45-leitlinien-der-dgn-2012/2391-ll-13-2012-tremor.html?q=holmes 2012
• 43 DGN DGfN. www.dgn.org/component/content/article/45-leitlinien-der-dgn-2012/2309-ll-50-2012-augenmotilitaetsstoerungen-inklusivenystagmus.html?q=nystagmus 2012