Mitochondrien und Altern

• Literatur

• 1 Anderson L. Identification of mitochondrial proteins and some of their precursors in two-dimensional electrophoretic maps of human cells. Proc Natl Acad Sci USA 1981; 78 (04) 2407-2411.
• 2 Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell 2005; 120 (04) 483-495.
• 3 Bauer MF, Hofmann S, Neupert W. Import of mitochondrial proteins. Int Rev Neurobiol 2002; 53: 57-90.
• 4 Bender A. et al. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet 2006; 38 (05) 515-517.
• 5 Bender A. et al. Creatine improves health and survival of mice. Neurobiol Aging 2008; 29 (09) 1404-1411.
• 6 Bjelakovic G. et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 2007; 297 (08) 842-857.
• 7 Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol 2005; 06 (04) 298-305.
• 8 Boveris A, Navarro A. Brain mitochondrial dysfunction in aging. IUBMB Life 2008; 60 (05) 308-314.
• 9 Cantuti-Castelvetri I. et al. Somatic mitochondrial DNA mutations in single neurons and glia. Neurobiol Aging 2005; 26 (10) 1343-1355.
• 10 Chinnery PF, Schon EA. Mitochondria. J Neurol Neurosurg Psychiatry 2003; 74 (09) 1188-1199.
• 11 Cooper JM, Mann VM, Schapira AH. Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing. J Neurol Sci 1992; 113 (01) 91-98.
• 12 Corral-Debrinski M. et al. Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat Genet 1992; 02 (04) 324-329.
• 13 Cortopassi GA, Arnheim N. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res 1990; 18 (23) 6927-6933.
• 14 Cortopassi GA. et al. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci U S A 1992; 89 (16) 7370-7374.
• 15 Cottrell DA. et al. Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age. Neurobiol Aging 2001; 22 (02) 265-272.
• 16 Dubec SJ, Aurora R, Zassenhaus HP. Mitochondrial DNA mutations may contribute to aging via cell death caused by peptides that induce cytochrome c release. Rejuvenation Res 2008; 11 (03) 611-619.
• 17 Dufour E. et al. Age-associated mosaic respiratory chain deficiency causes trans-neuronal degeneration. Hum Mol Genet 2008; 17 (10) 1418-1426.
• 18 Elson JL, Samuels DC, Turnbull DM, Chinnery PF. Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age. Am J Hum Genet 2001; 68 (03) 802-806.
• 19 Fayet G. et al. Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function. Neuromuscul Disord 2002; 12 (05) 484-493.
• 20 Ghosh HS. The anti-aging, metabolism potential of SIRT1. Curr Opin Investig Drugs 2008; 09 (10) 1095-1102.
• 21 Gokulrangan G. et al. Proteomic analysis of protein nitration in rat cerebellum: effect of biological aging. J Neurochem 2007; 100 (06) 1494-1504.
• 22 Guarente L. Mitochondria--a nexus for aging, calorie restriction, and sirtuins?. Cell 2008; 132 (02) 171-176.
• 23 Hamm-Alvarez S, Cadenas E. Mitochondrial medicine and mitochondrion-based therapeutics. Adv Drug Deliv Rev 2008; 60 13-14 1437-1438.
• 24 Hansen JM, Go YM, Jones DP. Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling. Annu Rev Pharmacol Toxicol 2006; 46: 215-234.
• 25 Harman D. The biologic clock: the mitochondria?. J Am Geriatr Soc 1972; 20 (04) 145-147.
• 26 Inoue K. et al. Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes. Nat Genet 2000; 26 (02) 176-181.
• 27 Khaidakov M, Siegel ER, Shmookler RJReis. Direct repeats in mitochondrial DNA and mammalian lifespan. Mech Ageing Dev 2006; 127 (10) 808-812.
• 28 Khrapko K, Vijg J. Mitochondrial DNA mutations and aging: devils in the details?. Trends Genet. 2008 epub ahead of print..
• 29 Kirkwood TB. Understanding the odd science of aging. Cell 2005; 120 (04) 437-447.
• 30 Kraytsberg Y. et al. Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons. Nat Genet 2006; 38 (05) 518-520.
• 31 Krishnan KJ. et al. A multiplex real-time PCR method to detect and quantify mitochondrial DNA deletions in individual cells. Anal Biochem 2007; 370 (01) 127-129.
• 32 Kujoth GC. et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 2005; 309 5733 481-484.
• 33 Kukat A, Trifunovic A. Somatic mtDNA mutations and aging--facts and fancies. Exp Gerontol 2009; 44 1-2 101-105.
• 34 Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 2006; 443 7113 787-795.
• 35 Linnane AW. et al. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989; 01 8639 642-645.
• 36 Medvedev ZA. An attempt at a rational classification of theories of ageing. Biol Rev Camb Philos Soc 1990; 65 (03) 375-398.
• 37 Melov S. et al. Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age. Nucleic Acids Res 1997; 25 (05) 974-982.
• 38 Milne JC. et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007; 450 7170 712-716.
• 39 Muller-Hocker J. Cytochrome-c-oxidase deficient cardiomyocytes in the human heart--an age-related phenomenon. A histochemical ultracytochemical study. Am J Pathol 1989; 134 (05) 1167-1173.
• 40 Muller-Hocker J. Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration. J Neurol Sci 1990; 100 1-2 14-21.
• 41 Munscher C. et al. The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages. FEBS Lett 1993; 317 1-2 27-30.
• 42 Navarro A, Boveris A. The mitochondrial energy transduction system and the aging process. Am J Physiol Cell Physiol 2007; 292 (02) C670-686.
• 43 Navarro A. et al. Dietary thioproline decreases spontaneous food intake and increases survival and neurological function in mice. Antioxid Redox Signal 2007; 09 (01) 131-141.
• 44 Nekhaeva E. et al. Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc Natl Acad Sci USA 2002; 99 (08) 5521-5526.
• 45 Ojaimi J. et al. Mitochondrial respiratory chain activity in the human brain as a function of age. Mech Ageing Dev 1999; 111 (01) 39-47.
• 46 Reddy PH. Mitochondrial Medicine for Aging and Neurodegenerative Diseases. Neuromolecular Med. 2008 epub ahead of print..
• 47 Reddy PH, Beal MF. Are mitochondria critical in the pathogenesis of Alzheimer’s disease?. Brain Res Brain Res Rev 2005; 49 (03) 618-632.
• 48 Reeve AK. et al. Nature of mitochondrial DNA deletions in substantia nigra neurons. Am J Hum Genet 2008; 82 (01) 228-235.
• 49 Sastre J. et al. A Ginkgo biloba extract (EGb 761) prevents mitochondrial aging by protecting against oxidative stress. Free Radic Biol Med 1998; 24 (02) 298-304.
• 50 Schriner SE. et al. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 2005; 308 5730 1909-1911.
• 51 Schulz TJ. et al. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab 2007; 06 (04) 280-293.
• 52 Sciacco M. et al. Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy. Hum Mol Genet 1994; 03 (01) 13-19.
• 53 Short KR. et al. Decline in skeletal muscle mitochondrial function with aging in humans. Proc Natl Acad Sci USA 2005; 102 (15) 5618-5623.
• 54 Soong NW. et al. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat Genet 1992; 02 (04) 318-323.
• 55 Srivastava S, Moraes CT. Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans. Hum Mol Genet 2005; 14 (07) 893-902.
• 56 St-Pierre J. et al. Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem 2002; 277 (47) 44784-90.
• 57 Taylor RW. et al. Mitochondrial DNA mutations in human colonic crypt stem cells. J Clin Invest 2003; 112 (09) 1351-1360.
• 58 Trifunovic A, Larsson NG. Mitochondrial dysfunction as a cause of ageing. J Intern Med 2008; 263 (02) 167-178.
• 59 Trifunovic A. et al. Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci USA 2005; 102 (50) 17993-8.
• 60 Trifunovic A. et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004; 429 6990 417-423.
• 61 Trounce I, Byrne E, Marzuki S. Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet 1989; 01 8639 637-639.
• 62 Tyynismaa H. et al. Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice. Proc Natl Acad Sci USA 2005; 102 (49) 17687-92.
• 63 Van Remmen H. et al. Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics 2003; 16 (01) 29-37.
• 64 Vermulst M. et al. Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet 2007; 39 (04) 540-543.
• 65 Vermulst M. et al. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet 2008; 40 (04) 392-394.
• 66 Vinogradov AD, Grivennikova VG. Generation of superoxide-radical by the NADH:ubiquinone oxidoreductase of heart mitochondria. Biochemistry (Mosc) 2005; 70 (02) 120-127.
• 67 Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu Rev Genet 2005; 39: 359-407.
• 68 Wallace DC. Mitochondria as chi. Genetics 2008; 179 (02) 727-735.
• 69 Wang Y. et al. Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc Natl Acad Sci USA 2001; 98 (07) 4022-4027.
• 70 Yen TC. et al. Liver mitochondrial respiratory functions decline with age. Biochem Biophys Res Commun 1989; 165 (03) 944-1003.
• 71 Yen WL, Klionsky DJ. How to live long and prosper: autophagy, mitochondria, and aging. Physiology (Bethesda) 2008; 23: 248-262.
• 72 Zhang C, Linnane AW, Nagley P. Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of ageing humans. Biochem Biophys Res Commun 1993; 195 (02) 1104-1110.
• 73 Zhang D. et al. Mitochondrial DNA mutations activate programmed cell survival in the mouse heart. Am J Physiol Heart Circ Physiol 2005; 288 (05) H2476-2483.