Download PDF
Nervenheilkunde 2009; 28(08): 518-522
DOI: 10.1055/s-0038-1628671
Suchterkrankungen
Schattauer GmbH

Bipolare Störungen und Abhängigkeitserkrankungen

KomorbiditätBipolar affective disorders and addiction disorderscomorbidity
U. W. Preuss
1   Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Martin-Luther-Universität, Halle-Wittenberg AWO Psychiatriezentrum Halle
,
M. W. Wong
1   Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Martin-Luther-Universität, Halle-Wittenberg AWO Psychiatriezentrum Halle
› Author Affiliations
Further Information

Publication History

Eingegangen am: 31 October 2008

angenommen am: 11 May 2009

Publication Date:
24 January 2018 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Alkohol- und substanzassoziierte Störungen (ASUD), insbesondere Abhängigkeitserkrankungen gehören zu den häufigsten komorbiden Störungen bei bipolar affektiven Erkrankungen (BAS). Diese komorbiden Störungen haben signifikanten Einfluss auf die Schwere der Erkrankung und deren Verlauf. Basierend auf einer Literaturrecherche ist das Ziel dieser Übersicht, aktuelle Befunde zur Epidemitologie, Ursachen und Verlauf beider komorbider Störungsbilder darzustellen und daraus Schlüsse für die Therapie dieser Betroffenen zu ziehen. Hierzu werden Ergebnisse aktueller Therapiestudien von BAS und ASUD vorgestellt.

Summary

Alcohol- and substance use disorders (ASUD) are considered to be among the most frequent comorbid disorders in bipolar affective disorders (BAS). ASUD have significant and negative influence on severity, course and prognoses of BAS. Based on a literature search, this review aims to present findings on epidemiology, causes and prognosis of comorbid BAS and ASUD. Finally, reporting recent results from therapy studies, consequences for treatment in BAS and ASUD are discussed.

Schlüsselwörter

Komorbidität - Alkoholabhängigkeit - Drogenabhängigkeit - bipolare Störungen

Keywords

Comorbidity - alcoholand substance use disorders - bipolar affective disorders
 

  • Literatur

  • 1 American Psychiatric Association Practice guideline for the treatment of patients with bipolar disorder (revision). Am J Psychiatry 2002; 159 (Suppl. 04) 1-50.
    CrossrefPubMedGoogle Scholar
  • 2 Angst J. et al. Toward a re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania. J Affect Disord 2003; 73 (1–2): 133-146.
    CrossrefPubMedGoogle Scholar
  • 3 Angst J. Bipolar disorder – methodological problems and future perspectives. Dialogues Clin Neurosci 2008; 10 (02) 129-139.
    PubMedGoogle Scholar
  • 4 Bowden CL. Predictors of response to divalproex and lithium. J Clinical Psychiatry 1995; 56 (Suppl. 03) 25-30.
    Google Scholar
  • 5 Brown ES. et al. Switching outpatients with bipolar or schizoaffective disorders and substance abuse from their current antipsychotic to aripiprazole. J Clin Psychiatry 2005; 66 (06) 756-760.
    CrossrefPubMedGoogle Scholar
  • 6 Brown ES. et al. Quetiapine in bipolar disorder and cocaine dependence. Bipolar Disord 2002; 04 (06) 406-411.
    CrossrefPubMedGoogle Scholar
  • 7 Brown ES. et al. Lamotrigine in patients with bipolar disorder and cocaine dependence. J Clin Psychiatry 2003; 64 (02) 197-201.
    CrossrefPubMedGoogle Scholar
  • 8 Brown ES. et al. Lamotrigine for bipolar disorder and comorbid cocaine dependence: a replication and extension study. J Affect Disord 2006; 93 (1–3): 219-222.
    CrossrefPubMedGoogle Scholar
  • 9 Cassidy F, Ahearn EP, Carroll BJ. Substance abuse in bipolar disorder. Bipolar Disord 2001; 03: 181-188.
    CrossrefGoogle Scholar
  • 10 Cerullo MA, Strakowski SM. The prevalence and significance of substance use disorders in bipolar type I and II disorder. Subst Abuse Treat Prev Policy 2007; 01: 29.
    Google Scholar
  • 11 Dixo L. et al. Remission of substance use disorders among psychiatric inpatients with mental health. illness. Amer J Psychiatr 1998; 155: 239-243.
    Google Scholar
  • 12 Farren CK, Mc SElroy. Treatment response of bipolar and unipolar alcoholics to an inpatient dual diagnosis program. JAffective Disorders 2008; 106 (03) 265-272.
    Google Scholar
  • 13 Feinman JA, Dunner DL. The effect of alcohol and substance abuse on the course of bipolar affective disorder. J Affective Disorders 1996; 37: 43-49.
    CrossrefPubMedGoogle Scholar
  • 14 Fleck DE. et al. Concurrent tracking of alcohol use and bipolar disorder symptoms. Bipolar Disord 2006; 08 (04) 338-344.
    CrossrefPubMedGoogle Scholar
  • 15 Ford JD. et al. Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals. Drug Alcohol Depend 2009; 99 (1–3): 193-203.
    CrossrefPubMedGoogle Scholar
  • 16 Grant B. et al. Prevalence, correlates, and comorbidity of bipolar I disorder and axis I and II disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry 2005; 66 (10) 1205-1215.
    CrossrefPubMedGoogle Scholar
  • 17 Kessler RC. et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 1994; 51: 8-19.
    CrossrefPubMedGoogle Scholar
  • 18 Mueser KT, Drake RE, Wallach MA. Dual diagnosis: a review of etiological theories. Addict Behav 1998; 23: 717-734.
    CrossrefPubMedGoogle Scholar
  • 19 Nejtek VA. et al. Do atypical antipsychotics effectively treat co-occurring bipolar disorder and stimulant dependence? A randomized, doubleblind trial. J Clin Psychiatry 2008; 69 (08) 1257-1266.
    CrossrefPubMedGoogle Scholar
  • 20 Preuss UW. Abhängigkeitserkrankungen und Psychosen: Erkenntnisse und Kontroversen in Vorbereitung auf neue Klassifikationssysteme. Die Psychiatrie 2008; 02: 61-68.
    Google Scholar
  • 21 Regier DA. et al. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study JAMA 1990; 264: 2511-2518.
    PubMedGoogle Scholar
  • 22 Salloum IM. et al. Divalproex utility in bipolar disorder with co-occurring cocaine dependence: a pilot study. Addict Behav 2007; 32 (02) 410-415.
    CrossrefPubMedGoogle Scholar
  • 23 Sonne SC, Brady KT. Bipolar disorder and alcoholism. Alcohol Research Health 2002; 26: 103-08.
    Google Scholar
  • 24 Sonne SC, Brady KT, Morton WA. Substance abuse and bipolar affective disorder. J Nerv Ment Dis 1994; 182 (06) 349-352.
    CrossrefPubMedGoogle Scholar
  • 25 Strakowski SM. et al. Effects of co-occurring alcohol abuse on the course of bipolar disorder following a first hospitalization for mania. Arch Gen Psychiatry 2005; 62 (08) 851-858.
    CrossrefPubMedGoogle Scholar
  • 26 Strakowski SM. et al. The impact of substance abuse on the course of bipolar disorder. Biol Psychiatry 2000; 48: 477-485.
    CrossrefPubMedGoogle Scholar
  • 27 Strakowski SM. et al. Effects of co-occurring cannabis use disorders on the course of bipolar disorder after a first hospitalization for mania. Arch Gen Psychiatry 2007; 64: 57-64.
    CrossrefPubMedGoogle Scholar
  • 28 Strakowski SM. et al. Comorbidity in mania at first hospitalization. Am J Psychiatry 1992; 149: 554-556.
    CrossrefPubMedGoogle Scholar
  • 29 Brady KT, Verduin ML, Tolliver BK. Treatment of patients comorbid for addiction and other psychiatric disorders. Curr Psychiatry Rep 2007; 09: 374-380.
    CrossrefPubMedGoogle Scholar
  • 30 Schuckit MA. et al. Comparison of induced and independent major depressive disorders in 2,945 alcoholics. Am J Psychiatry 1997; 154: 948-957.
    CrossrefPubMedGoogle Scholar
  • 31 Khantzian EJ. The Self-medication hypothesis of substance use disorders: a reconsideration and recent applications. Hav Rev Psychiatry 1997; 04: 231-44.
    Google Scholar
  • 32 Soyka M. Substance misuse, psychiatric disorder and violent and disturbed behaviour. Br J Psychiatry 2000; 176: 345-350.
    CrossrefPubMedGoogle Scholar
  • 33 Soyka M, Lieb M. Komorbidität von Depression und Alkoholabhängigkeit: Klinische und neurobiologische Aspekte. Nervenheilkunde 2004; 23: 13-17.
    Article in Thieme ConnectGoogle Scholar