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DOI: 10.1055/s-0038-1628903
Localization of 99mTc-Diphosphonates in Newly Formed Bone Matrix as a Measure of Bone Lesion Detectability[*]
Publikationsverlauf
Received:
17. Dezember 1987
Publikationsdatum:
04. Februar 2018 (online)
The lesion-to-normal-bone ratios of DBA-MDP (dibutylamino-methylene-diphosphonate), DPD (dicarboxypropane-diphosphonate) and MDP (methylene-diphosphonate) each labeled with 99mTc, were evaluated in experimental bone lesions. In 3-day old lesions this ratio was increased twofold for DBA-MDP in comparison with MDP and DPD which showed nearly equal ratios. Later on these differences became negligibly small. It is concluded that 99mTc-DBA-MDP is fixed more strongly in the immature bone matrix and that this will lead to an improvement in the detectability of lesions containing larger amounts of immature bone matrix.
Zusammenfassung
Das Anreicherungsverhältnis zwischen experimentellen Knochenläsionen und normalem Knochen wurde für 99mTc-markiertes DBA-MDP (Dibutylamino-Methylen-Diphosphonat), DPD (Dicarboxypropan-Diphosphonat) und MDP (Methylen-Diphosphonat) gemessen. Bei 3 Tage alten Läsionen war dieses Verhältnis bei 99mTc-DBA-MDP um das Zweifache gegenüber MDP und DPD erhöht. Später wurden diese Unterschiede vernachlässigbar klein. Es wird die Schlußfolgerung gezogen, daß 99mTc-DBA-MDP in der unreifen Knochenmatrix stärker fixiert wird, und daß deshalb die Nachweiswahrscheinlichkeit von Knochenläsionen, die größere Mengen an unreifer Knochenmatrix enthalten, verbessert wird.
* Dedicated to Professor Dr. G. Löhr on the occasion of his 65th birthday.
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