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Nuklearmedizin 1990; 29(01): 28-34
DOI: 10.1055/s-0038-1629509
Originaler Artikel
Schattauer GmbH

The Influence of Lactate and Dipyridamole on Myocardial Fatty Acid Metabolism in Man, Traced with 123l-17-lodo-heptadecanoic Acid[*]

Der Einfluß von Lactat und Dipyridamol auf den myokardialen Fettsäuremetabolismus beim Menschen,verfolgt mit 123-Iod-17-lodoheptadecansäure
C. M. B. Duwel
2   The Nuclear Medicine Department, Universitätsspital, Zürich, Switzerland
,
F. C. Visser
1   From the Department of Cardiology, Free University Hospital, Amsterdam, The Netherlands
,
M. J. van Eenige
1   From the Department of Cardiology, Free University Hospital, Amsterdam, The Netherlands
,
G. Westera
1   From the Department of Cardiology, Free University Hospital, Amsterdam, The Netherlands
,
J. P. Roos
1   From the Department of Cardiology, Free University Hospital, Amsterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

Received: 30 October 1989

Publication Date:
04 February 2018 (online)

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Changes in myocardial metabolism can be detected externally by registration of time-activity curves after administration of radioiodinated fatty acids. In this scintigraphic study the influence of lactate on fatty acid metabolism was investigated in the normal human myocardium, traced with 123l-17-iodoheptadecanoic acid (123l-17-HDA). In patients (paired, n = 7) lactate loading decreased the uptake of 123l-17-HDA significantly from 27 (control: 22-36) to 20 counts/min/pixel (16-31; p <0.05 Wilcoxon). The half-time value increased to more than 60 rriin (n = 5), oxidation decreased from 61 to 42%. Coronary vasodilatation, a well-known side effect of lactate loading, was studied separately in a dipyridamole study (paired, n = 6). Coronary vasodilatation did not influence the parameters of the time-activity curve. These results suggest that changes in plasma lactate level as occurring, among other effects, during exercise will influence the parameters of dynamic 123l-17-HDA scintigraphy of the heart.

Zusammenfassung

Nach intravenöser Applikation von jodmarkierter Fettsäure können Veränderungen im Myokardstoffwechsel durch externe Registrierung von Zeitaktivitätskurven festgestellt werden. In dieser szintigraphischen Studie wurde mittels 123I-17-Jod-Heptadekansäure (123J-17-HDA) der Einfluß des Laktats auf den Fettsäurestoffwechsel im gesunden menschlichen Myokard untersucht. Bei Patienten (n = 7) verringerte gleichzeitige Gabe von Laktat die myokardiale Aufnahme von 123I-17-HDA signifikant von 27 (Streubreite 22-36) auf 20 Counts/ min/Pixel (16-31; p <0,05). Die Halbwertszeit stieg auf Werte über 60 min (n = 5), die relative Poolgröße der Oxidation verringerte sich von 61 auf 42%. Die koronare Gefäßerweiterung, eine bekannte Nebenwirkung der Laktat-Belastung, wurde in einer Dipyridamolstudie separat untersucht (n = 6). Die koronare Dilatation hatte keinen Einfluß auf die Parameter. Diese Ergebnisse legen nahe, daß bei Änderungen im Plasma-Laktatspiegel die myokardialen Parameter der dynamischen 123I-17-HDA-Szintigraphie beeinflußt werden.

* Presented at the 34th Meeting of the Society of Nuclear Medicine, Toronto, 1987 (J Nucl Med 1987; 28: 567).


 

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