Download PDF
Nuklearmedizin 1998; 37(02): 73-75
DOI: 10.1055/s-0038-1629796
Originalarbeiten — Original Articles
Schattauer GmbH

Positive I-123-MIBG-Scintigraphy in Osteosarcoma

Positive I-123-MIBG-Szintigraphie bei Osteosarkom
K. von der Hardt
1   From the Departments of Pediatrics, University of Erlangen-Nürnberg, Germany
,
H.-J. Bair
2   From the Departments of, Nuclear medicine and, University of Erlangen-Nürnberg, Germany
,
T. Kirchner
3   From the Departments of, Pathology, University of Erlangen-Nürnberg, Germany
,
H. Feistel
2   From the Departments of, Nuclear medicine and, University of Erlangen-Nürnberg, Germany
,
J. Beck
1   From the Departments of Pediatrics, University of Erlangen-Nürnberg, Germany
› Author Affiliations
Further Information

Publication History

Received: 11 August 1997

accepted: 22 August 1997

Publication Date:
03 February 2018 (online)

Also available at
    Permissions and Reprints

Summary

I-123-MIBG scintigraphy has become a standard imaging technique in the detection of neuroendocrine or neurocrest derived tumors, especially neuroblastoma and pheochromocytoma. We report on a positive I-123-MIBG uptake in a pediatric osteosarcoma patient and demonstrate, that unusual results still occur with this established imaging method.

Zusammenfassung

Die sI-123-MIBG-Szintigraphie ist eine Standarduntersuchung in der bildgebenden Diagnostik von neuroendokrinen Tumoren bzw. von Tumoren, die sich von Neuralleistengewebe ableiten lassen (insbesondere Neuroblastome und Phäochromozytome). Wir berichten von einer positiven I-123-MIBG-Szintigraphie bei einer jugendlichen Patientin mit Osteosarkom und zeigen, daß noch immer mit ungewöhnlichen Ergebnissen bei dieser etablierten Standarduntersuchung gerechnet werden muß.

Keywords

I-123-MIBG scintigraphy - osteosarcoma - pediatric

Schlüsselwörter

I-123-MIBG Szintigraphie - Osteosarkom - pädiatrisch
 

  • References

  • 1 Bair HJ, Behr T, von der Hardt K. et al. Unusual MIBG uptake patterns in children. 2nd European Symposium on pediatric nuclear medicine Domènech-Tormé FM, Hahn K, Rocca I. (eds) 1995
    PubMedSearch in Google Scholar
  • 2 Bomanji J, Hungerford JL, Kingston JE. et al. 123-1 metaiodobenzylguanidine (MIBG) scintigraphy of retinoblastoma: preliminary experience. Br J Ophthalm 1989; 73: 146-50.
    Search in Google Scholar
  • 3 Bonnin F, Lumbroso J, Tenenbaum F. et al. Refining interpretation of MIBG Scans in children. J Nucl Med 1994; 35: 803-10.
    PubMedSearch in Google Scholar
  • 4 Bouvier JF, Philip T, Chauvot P. et al. Pitfalls and solutions in neuroblastome diagnosis using radioiodine MIBG. Prog Clin Biol Res 1988; 271: 707-20.
    PubMedSearch in Google Scholar
  • 5 Buck J, Bruchelt G, Girgert R. et al. Specific uptake of m(125-I)iodobenzylguanidine in the human neuroblastoma cell line SK-N-SH. Cancer Res 1985; 45: 6366-70.
    PubMedSearch in Google Scholar
  • 6 Feggi L, Degli Uberti E, Pansini GC. et al. Pitfalls in scintigraphic detection of neuroendocrine tumours. Eur J Nucl Med 1992; 19: 214-8.
    PubMedSearch in Google Scholar
  • 7 Geatti O, Shapiro B, Barillari B. Scintigraphic depiction of an insulinoma by I-131 metaiodobenzylguanidine. Clin Nucl Med 1989; 14: 903-5.
    CrossrefPubMedSearch in Google Scholar
  • 8 Hayward RS, Bowering CK, Warshawski RS. I-131 metaiodobenzylguanidine uptake in a parathyroid adenoma. Clin Nucl Med 1988; 13: 632-4.
    CrossrefPubMedSearch in Google Scholar
  • 9 Hoefnagel CA. Metaiodobenzylguanidine and somatostatin in oncology: role in the management of neural crest tumors. Eur J Nucl Med 1994; 21: 561-81.
    PubMedSearch in Google Scholar
  • 10 Home T, Glaser B, Krausz Y. et al. Unusual causes of I-131 metaiodobenzylguanidine uptake in non-neural crest tissue. Clin Nucl Med 1991; 16: 239-42.
    CrossrefPubMedSearch in Google Scholar
  • 11 Jaques S, Tobes MC, Sisson JC. et al. Comparison of the sodium dependency of uptake of meta-iodobenzylguanidine and norepinephrine into cultured bovine adrenomedul-lary cells. Mol Pharmacol 1984; 26: 539-46.
    PubMedSearch in Google Scholar
  • 12 Jaques S, Tobes MC, Sisson JC. Sodium dependency of uptake of norepinephrine and m-iodobenzylguanidine into cultured human pheochromocytoma cells: evidence for uptake-one. Cancer Res 1987; 47: 3920-8.
    PubMedSearch in Google Scholar
  • 13 von Moll L, McEwan AJ, Shapiro B. Iodine-131 MIBG Scintigraphy of neuroendocrine tumors other than pheochromocytoma and neuroblastoma. J Nucl Med 1987; 28: 979-88.
    PubMedSearch in Google Scholar
  • 14 Muino Miguez A, Robles Perez R, Lopez Gomez JM. et al. Falso positivo con MIBG en la localización del feocromocitoma. Medicina Clínica 1986; 86: 437.
    PubMedSearch in Google Scholar
  • 15 Parisi MT, Sandler ED, Hattner RS. The biodistribution of metaiodobenzylguanidine. Sem Nucl Med 1992; 22: 46-8.
    Search in Google Scholar
  • 16 Saint-Andre JP, Chapeau MC, Pein F. Nephroblastome avec differentiation neuronale symptomatique. Ann Path 1988; 8: 144-8.
    Search in Google Scholar
  • 17 Shapiro B, Copp JE, Sisson JC. Iodine-131 Metaiodobenzylguanidine for the locating of suspected pheochromocytoma: Experience in 400 cases. J Nucl Med 1985; 26: 576-85.
    PubMedSearch in Google Scholar
  • 18 Smets LA, Loesberg C, Janssen M. et al. Active uptake and extravesicular storage of m-iodobenzylguanidine in human neuroblastoma SK-N-SH cells. Cancer Res 1989; 49: 2941-4.
    PubMedSearch in Google Scholar
  • 19 Stewart RE, Grossmann DM, Shulkin BL. et al. Iodine-131 metaiodobenzylguanidine uptake in infantile myofibromatosis. Clin Nucl Med 1989; 14: 344-6.
    CrossrefPubMedSearch in Google Scholar
  • 20 Treuner J. Aspekte der Anwendung von 131 J-Metajodbenzylguanidin aus der Sicht der paediatrischen Onkologie. Nuklearmedizin 1985; 24: 26-8.
    Thieme ConnectPubMedSearch in Google Scholar