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Nervenheilkunde 2005; 24(03): 211-216
DOI: 10.1055/s-0038-1629954
Deutsche MigrÄne- Und Kopfschmerz-Gexellschaft
Schattauer GmbH

Migräneprophylaxe mit Petasites (Pestwurz)

Klinik und Pharmakologie eines SpezialextraktsMigraine prevention with Petasites (Butterbur)Clinic and pharmacology of a special root extract
H. Göbel
1   Neurologisch-verhaltensmedizinische Schmerzklinik Kiel
,
R. Pothmann
2   Klinikum Heidberg, Zentrum für Kinderschmerztherapie, Hamburg
,
R. Bauer
3   Institut für pharmazeutische Wissenschaften, Pharmakognosie, Karl-Franzens-Universität Graz
,
U. Danesch
3   Institut für pharmazeutische Wissenschaften, Pharmakognosie, Karl-Franzens-Universität Graz
› Institutsangaben
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Publikationsverlauf

Publikationsdatum:
31. Januar 2018 (online)

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Zusammenfassung

Seit vielen Jahrhunderten wird die Pestwurz (Petasites hybridus) traditionell bei Schmerzen, Fieber und krampfartigen Zuständen eingesetzt. Pharmakologisch handelt es sich bei dem Pestwurz-Spezialextrakt um einen Lipoxygenase- und selektiven Zyklooxygenase-2-Hemmer. In der heutigen Medizin dient die Pestwurz hauptsächlich zur Prophylaxe von Migräneanfällen. Die Wirksamkeit und Sicherheit eines Pestwurz-Spezialextrakts aus dem Rhizom wurde in zwei randomisierten, doppelblinden und Plazebo-kontrollierten Studien mit mehr als 300 Patienten belegt. Die Zahl der Migräneanfälle konnte deutlich reduziert werden, bei mehr als zwei Drittel aller Patienten um mindestens 50%. Eine vergleichbare Wirkung wurde auch bei 108 Kindern und Jugendlichen in einer offenen Studie gezeigt. Nebenwirkungen sind selten und von milder Natur; überwiegend wurden Magenstörungen wie Ruktus berichtet.

Summary

For many centuries butterbur (Petasites hybridus) was traditionally used for conditions like pain, fever and spasms. Pharmacologically, the special butterbur root extract is a lipoxygenase and specific cyclooxygenase-2 inhibitor. Today, butterbur is mainly prescribed for migraine prevention. Efficacy and tolerability of a special butterbur root extract was demonstrated in two randomised, double-blind and placebo-controlled clinical trials with more than 300 patients. Migraine attacks could be significantly reduced. Also, more than two thirds of all patients experienced a reduction of migraine attacks of 50% or greater. A comparable efficacy was also demonstrated in an open trial with 108 children and adolescents. Side effects are rare and of mild nature, gastrointestinal discomfort like eructation is mostly reported.

Schlüsselwörter

Pestwurz - Migräneprophylaxe - Petasine - Lipoxygenase - Zyklooxygenase

Keywords

Butterbur - migraine prevention - petasins - lipoxygenase - cyclooxygenase
 

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