RSS-Feed abonnieren
DOI: 10.1055/s-0038-1632425
The Influence of Sequential Intratendinous Sodium Hyaluronate on Tendon Healing in Horses
Publikationsverlauf
Received for publication 08. Juni 1994
Publikationsdatum:
09. Februar 2018 (online)
Summary
Acute tendinitis was bilaterally created in the mid-metacarpal region of the superficial digital flexor tendons of six horses with intratendinous collagenase administration. The collagenase-induced lesion, in one superficial flexor tendon of each horse, was injected 48 h later with 10.0 mg of sodium hyaluronate (1.0 ml) under ultrasound guidance. In order to serve as a control, the lesion in the contralateral superficial digital flexor tendon was injected with 1.0 ml of phosphate buffered 0.9% sodium chloride. Similar injections were made at weekly intervals for six weeks. Differences could not be detected between sequential sodium hyaluronate treated tendons and control tendons using ultrasonographic, lameness, gross pathological nor histological evaluations.
Collagenase-induced superficial digital flexor tendinitis lesions were treated with repeated, sequential intratendinous administration of sodium hyaluronate in six horses. A significant difference in size of the tendon lesions, tendon enlargement, lameness, or tendon healing was not detected between repeated, sequential intratendinous sodium hyaluronate treated and control tendons. The multiple intratendinous injection is not recommended for horses with flexor tendinitis.
-
REFERENCES
- 1 Mcllwraith CW. Diseases of joints, tendons, ligaments and related structures. In: Adams’ Lameness in Horses. Stashak TS. ed Philadelphia: Lea & Febiger; 1987: 447-63.
- 2 McCullagh KG, Goodship AE, Silver IA. Tendon injuries and their treatment in the horse. Veterinary Record 1979; 105: 54-7.
- 3 Williams IF, McCullagh KG, Goodship AE. et al Studies on the pathogenesis of equine tendonitis following collagenase injury. Res Vet Sci 1984; 36: 326-38.
- 4 Silver IA, Brown PN, Goodship AE. et al A clinical and experimental study of tendon injury, healing and treatment in the horse. Equine Vet J 1983; Suppl 1: 10-2.
- 5 Jackson RL, Busch SJ, Cardin AD. Glycosaminoglycans: molecular properties, protein interactions, and role in physiologic processes. Physiol Rev 1991; 71 (02) 481-2.
- 6 Varma R, Varma RS. Chemistry and metabolism of glycosaminoglycans and proteoglycans. In: Mucopolysaccharides, Glycosaminoglycans of Body Fluids in Health and Disease. Berlin: Walter de Gruyter and Co; 1983: 22-3.
- 7 Balazs EA, Denlinger JL. Sodium hyaluronate and joint function. Equine Vet Sci 1985; 5 (04) 217-28.
- 8 Goldberg RL, Toole BP. Hyaluronate inhibition of cell proliferation. Arthritis and Rheum 1987; 30 (07) 769-78.
- 9 Balazs EA, Darynkiewicz A. The effect of hyaluronic acid on fibroblasts, mononuclear phagocytes, and lymphocytes. In: Biology of the Fibroblast. Kulonen E, Pikkarainen J. eds San Diego: Academic Press; 1973: 237-52.
- 10 Gaughan EM, Nixon AJ, Krook LP. et al Effects of sodium hyaluronate on tendon healing and adhesion formation in horses. Am J Vet Res 1991; 52 (05) 764-73.
- 11 Spurlock GH, Spurlock SL, Parker GA. Evaluation of Hylartin V therapy for induced tendinitis in the horse. Equine Vet Sci 1989; 9 (05) 242-6.
- 12 Churchill EA. Treating tendinitis with sodium hyaluronate. Equine Vet Sci 1985; 5 (04) 240-1.
- 13 Genovese RL, Rantanen NW, Hauser ML. et al Diagnostic ultrasonography of equine limbs. Vet Clin North Am (Equine Pract) 1986; 2 (01) 170
- 14 Foland JW, Trotter GW, Powers BE. et al Sodium hyaluronate in induced equine digital flexor tendinitis. Vet Surg 1991; 20 (05) 336
- 15 Gift LJ, Gaughan EM, De Bowes RM. et al The influence of intratendinous sodium hyaluronate on tendon healing in horses. V. C. O. T 1992; 5: 151-7.
- 16 Hilbert BJ, Rowley G, Antonas KN. et al Changes in the synovia after the intraarticular injection of sodium hyaluronate into normal joints and after arthrotomy and experimental cartilage damage. Aust Vet J 1985; 62 (06) 182-4.