Foreign Body Granulomatous Response to Particulate Bony Debris

J. H. Boss; Z. Ish-Shalom; I. Misselevich; D. G. Mendes

doi:10.1055/s-0038-1632516

Veterinary and Comparative Orthopaedics and Traumatology, Table of Contents

Vet Comp Orthop Traumatol 1996; 09(03): 119-25
DOI: 10.1055/s-0038-1632516

Original Research

Schattauer GmbH

Foreign Body Granulomatous Response to Particulate Bony Debris

J. H. Boss

¹From the Department of Pathology, Bnai-Zion Medical Center

,

Z. Ish-Shalom

²Department of Endocrinology, Rambam Medical Center

,

I. Misselevich

¹From the Department of Pathology, Bnai-Zion Medical Center

,

D. G. Mendes

³Center for Implant Surgery and the Association of Patients with Implanted Joints, the Bruce Rapapport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel

› Author Affiliations

Abstract

Summary

Archival material was retrieved in order to histologically assess the body’s response to micron-sized, necrotic bony particles. Specimens were obtained from (1) human bone grafts in a subcutaneous or muscular pouch of athymic nude mice, (2) a massive bone allograft replacing a patient’s humerus, (3) rabbits’ healing tibial cortical bone defects littered with finely dispersed bony particles, (4) periprosthetic tissues of patient’s aseptically loosened artificial joints and (5) interfacial membranes of intramedullary nails used for fixation of patients’ fractured long bones. Necrotic bony debris was found to induce a giant celled granulomatous reaction. In sections of undecalcified samples stained by the von Kossa method, small calcific particles were observed to be present within polykaryonic macrophages (foreign body giant cells) and surrounded by mononuclear macrophages. It is concluded that a foreign body-type giant celled granulation tissue participates in the degradation of micron-sized, necrotic bony detritus, whether the disintegrating bone is of the xeno-, alio- or autogenic provenance.

Histological examination of von Kossa-stained sections, of undecalcified specimens, revealed a giant celled granulomatous response to bony debris. Irrespective of whether or not the disintegrating bone was of auto-, alio- or xenogeneic provenance, micron-sized bony particles were found to be phagocytosed by polykaryonic macrophages of the granulation tissue.

Keywords

Foreign body giant cell - osteoclast - bone xenograft - bone allograft - necrotic bone - interfacial membrane

Full Text

References

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