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Vet Comp Orthop Traumatol 2000; 13(01): 23-27
DOI: 10.1055/s-0038-1632625
Clinical Communication
Schattauer GmbH

Osteogenesis imperfecta in Three Dogs from a Single Litter

T. Lazar
1   Afliliated Veterinary Specialists, P. A., Winter Park, Florida
,
J. J. deHaan
1   Afliliated Veterinary Specialists, P. A., Winter Park, Florida
,
J. N. Peck
1   Afliliated Veterinary Specialists, P. A., Winter Park, Florida
,
Bonnie G. Campbell
2   Department of Biomedical Sciences, Cornell University, Ithaca, New York
,
Pamela E. Ginn
3   Department of Pathobiology, University of Florida, Gainesville, Florida
,
Lynette Phillips
3   Department of Pathobiology, University of Florida, Gainesville, Florida
,
A. Suero
4   Tuscawilla Animal Hospital, Winter Springs, Florida
,
B. J. Chase
5   Jewett Orthopaedic Clinic, Winter Park, Florida, U.S.A
› Author Affiliations
Further Information

Publication History

Received 19 March 1999

Accepted 02 June 1999

Publication Date:
09 February 2018 (online)

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Summary

Three American Cream puppies from a litter of six were admitted for evaluation and treatment of lameness caused by multiple pathological fractures. Because of a poor prognosis, all three of the affected dogs were ultimately euthanatized. Based on the histopathological findings of the bones and a collagen analysis from cultured skin fibroblast cells which confirmed the presence of abnormal type I collagen, the presumptive diagnosis was osteogenesis imperfecta. In humans, more than 90% of the cases of osteogenesis imperfecta are caused by defects in type I collagen (11). Osteogenesis imperfecta has rarely been described in animals and none of the previous reports document the disease in more than one dog from a single litter.

Three American Cream puppies from a litter of six developed multiple pathologic features without a history of trauma. A diagnosis of osteogenesis imperfecta was made based on histopathology and results of type I collagen analysis from cultured skin fibroblasts.

Keywords

Osteogenesis imperfecta - collagen - dog
 

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