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Vet Comp Orthop Traumatol 2002; 15(02): 67-71
DOI: 10.1055/s-0038-1632716
Original Research
Schattauer GmbH

Biomarkers of bone metabolism in horses: Ante-mortem versus post-mortem correlation in serum and aqueous humour

S. R. McClure
1   Department of Veterinary Clinical Sciences, West Lafayette, IN, USA
,
L. T. Glickman
2   Department of Veterinary Pathobiology, West Lafayette, IN, USA
,
N. W. Glickman
3   Center for the Human-Animal Bond, School of Veterinary Medicine, Purdue University, West Lafayette, IN, USA
,
E. S. Rasmussen
1   Department of Veterinary Clinical Sciences, West Lafayette, IN, USA
,
S. J. Carlson
1   Department of Veterinary Clinical Sciences, West Lafayette, IN, USA
,
G. J. Breur
1   Department of Veterinary Clinical Sciences, West Lafayette, IN, USA
› Author AffiliationsThis work was supported by the State of Indiana and Purdue University School of Veterinary Medicine Research account funded by the Total Wagers Tax.
Further Information

Publication History

Received 20 June 2001

Accepted 23 August 2001

Publication Date:
07 February 2018 (online)

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Summary

The objective of this study was to determine the correlation between ante-mortem and 24-hour postmortem concentrations of four markers of bone metabolism in equine serum and aqueous humour. The markers evaluated were osteocalcin, bone alkaline phosphatase, carboxyterminal propeptide of type-1 procollagen and carboxyterminal cross-linked telopeptide of type-1 collagen (ICTP). The concentrations of these markers were poorly correlated (P > 0.05) between aqueous humour and serum. ICTP was the only serum marker significantly correlated (r = 0.93) between ante- and post-mortem samples. ICTP is, therefore, a potential marker for evaluating antemortem markers of bone metabolism in dead horses.

Keywords

Biomarkers - bone metabolism - stress fracture
 

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